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Chromium (III) oxide (2:3)

RTECS #: GB6475000

CAS #: 1308-38-9


UPDATE: May 2009 MW: 152.00 MF: Cr2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 11661 Green
  2. Anhydride chromique (French)
  3. C.I. 77288
  4. C.I. Pigment Green 17
  5. Casalis Green
  6. Chrome Oxide Green GN - M
  7. Chrome Green
  8. Chrome ochre
  9. Chrome Oxide Green BX
  10. Chromia
  11. Chromic Acid Green
  12. Chromic oxide
  13. Chromium oxide (Cr8O12)
  14. Chromium Oxide X1134
  15. Chromium (3+) oxide
  1. Chromium Oxide Green
  2. Chromium Oxide Pigment
  3. Chromium sesquioxide
  4. Dichromium trioxide
  5. Green Chrome Oxide
  6. Green Oxide of Chromium
  7. Green chromic oxide
  8. Green chromium oxide
  9. Green cinnabar
  10. Green oxide of chromium OC - 31
  11. Levanox Green GA
  12. OKhP1
  13. P 106F10
  14. PK 5304
  15. Pure Chromium Oxide Green 59


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
mutation in microorganisms Salmonella typhimurium 10 g/plate (+enzymatic activation step) DCTODJ 4,185,1981
mutation in mammalian somatic cells hamster lung 50 mg/L MUREAV 169,159,1986
other mutation test systems hamster lung 100 mg/L MUREAV 169,159,1986
sister chromatid exchange hamster lung 34 mg/L CRNGDP 4,605,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intrapleural
rat
lowest published toxic dose: 45 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
VOONAW 13(11),57,1967
intraperitoneal
rat
lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
VOONAW 13(11),57,1967
intratracheal
rat
lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
VOONAW 13(11),57,1967


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mammal (species unspecified)
lethal dose (50 percent kill): 621 mg/kg N/R TOVEFN (2),18,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 4.2 mg/m3/24 hour/17 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,303,1989
inhalation
rat
lowest published toxic concentration: 15 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Endocrine: Changes in thyroid weight
TOSCF2 52,278,1999
inhalation
rat
lowest published toxic concentration: 150 mg/m3/45 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,162,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2 mg(Cr)/m3, FEB 2006
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg(Cr)/m3, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Cr)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Cr)/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2273;
Number of Industries 49;
Total Number of Facilities 3,141;
Number of Occupations 66;
Total Number of Employees Exposed 42,380
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0962;
Number of Industries 7;
Total Number of Facilities 288;
Number of Occupations 26;
Total Number of Employees Exposed 8,322
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0962;
Number of Industries 87;
Total Number of Facilities 7,613;
Number of Occupations 56;
Total Number of Employees Exposed 88,897;
Total Number of Female Employees Exposed 11,984


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pigment, in manufacture of CHROMIUM and its alloys, and as a catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

Used as a pigment, in manufacture of CHROMIUM and its alloys, and as a catalyst

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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