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Chromium hydroxide sulfate

RTECS #: GB6240000

CAS #: 12336-95-7


UPDATE: May 2009 MW: 165.07 MF: CrHO5S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Basic chromic sulfate
  2. Basic chromium sulfate
  3. Chromedol
  1. Cromo solfato basificato (Spanish)
  2. Monobasic chromium sulfate
  3. Peachrome


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg severe TOVEFN (2)34,1998


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 5 mg/L BJCAAI 44,219,1981
cytogenetic analysis human other cell types 500 mg/L BJCAAI 44,219,1981
DNA inhibition hamster kidney 500 mg/L BJCAAI 44,219,1981
other mutation test systems hamster kidney 500 mg/L BJCAAI 44,219,1981
other mutation test systems human other cell types 500 mg/L BJCAAI 44,219,1981
sister chromatid exchange hamster ovary 10 mg/L CRNGDP 6,1327,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
ocular
rabbit
lowest published toxic dose: 25 mg/kg Eye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects
TOVEFN (2),39,1998
oral
mouse
lethal dose (50 percent kill): 2,900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability
TOVEFN (2),34,1998
oral
mouse
lethal dose (50 percent kill): 2,900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
TOVEFN (2),39,1998
oral
rat
lethal dose (50 percent kill): 7,760 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability
TOVEFN (2),34,1998
oral
rat
lethal dose (50 percent kill): 7,760 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
TOVEFN (2),39,1998
oral
woman
lowest published lethal dose: 960 mg/kg Cardiac: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Necrotic changes
ICMED9 20,145,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 58 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
NTIS** OTS0557882
inhalation
rat
lowest published toxic concentration: 17 mg/m3/6 hour/5 day- intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 52,278,1999
oral
rat
lowest published toxic dose: 23,280 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOVEFN (2),34,1998
oral
rat
lowest published toxic dose: 23,280 mg/kg/30 day- intermittent Cardiac: Changes in heart weight

Liver: Liver function tests impaired

Liver: Other changes
TOVEFN (2),39,1998
oral
rat
lowest published toxic dose: 23,280 mg/kg/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOVEFN (2),39,1998
oral
rat
lowest published toxic dose: 23,280 mg/kg/30 day- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOVEFN (2),39,1998
oral
rat
lowest published toxic dose: 23,280 mg/kg/30 day- intermittent Related to Chronic Data: Changes in testicular weight TOVEFN (2),39,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 49,49,1990


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2 mg(Cr)/m3, FEB 2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg(Cr)/m3, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Cr)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 0.02 mg(Cr)/m3, short term exposure limit 0.06 mg(Cr)/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Cr)/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0022;
Number of Industries 2;
Total Number of Facilities 51;
Number of Occupations 4;
Total Number of Employees Exposed 1,155;
Total Number of Female Employees Exposed 51


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the tanning industry
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used in the tanning industry

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 39380-78-4
Click Here for Additional Information about RTECS

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