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Chromium (III) chloride, hexahydrate (1:3:6)

RTECS #: GB5450000

CAS #: 10060-12-5


UPDATE: May 2009 MW: 266.47 MF: Cl3Cr6H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chlorid chromity hexahydrat (Czech)
  2. Chromic chloride hexahydrate
  3. Chromium chloride, hexahydrate (8CI,9CI)
  4. Chromium sesquichloride
  1. Chromium trichloride hexahydrate
  2. Hexaaquachromium chloride
  3. Hexaaquachromium (III) chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 2,500 g/L MUREAV 191,207,1987
cytogenetic analysis human leukocyte 400 mg/L SAIGBL 18,136,1976
DNA adduct hamster kidney 500 mg/L CBINA8 37,309,1981
DNA adduct intraperitoneal
rat
80 mg/kg CNREA8 45,1146,1985
DNA damage cattle other cell types 0.1 mmol/L/1 hour EVHPAZ 108,399,2000
DNA damage hamster lung 10 mol/L MUREAV 117,279,1983
DNA repair Escherichia coli 31 g/well MUREAV 133,161,1984
other mutation test systems hamster kidney 500 mg/L CBINA8 37,309,1981
other mutation test systems human other cell types 500 mg/L BJCAAI 44,219,1981
sister chromatid exchange hamster lung 39 mg/L CRNGDP 4,605,1983
sister chromatid exchange hamster fibroblast 32 mg/L MUREAV 104,141,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 134 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system
TXCYAC 26,257,1983
intraperitoneal
mouse
lowest published toxic dose: 266 mg/kg (1 day male) Reproductive: Other reproductive system tumors TXAPA9 158,161,1999
intraperitoneal
mouse
lowest published toxic dose: 266.5 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on newborn: Biochemical and metabolic
EVHPAZ 110,801,2002
intraperitoneal
mouse
lowest published toxic dose: 26.6 mg/kg (1 day male) Reproductive: Effects on newborn: Biochemical and metabolic EVHPAZ 110,801,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 285 mg/kg N/R TXAPA9 63,461,1982
intraperitoneal
mouse
lowest published toxic dose: 266.47 mg/kg Endocrine: Hyperglycemia

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 110,801,2002
intravenous
frog
lowest published lethal dose: 374 mg/kg N/R AIPTAK 62,330,1939
intravenous
mouse
lowest published lethal dose: 1,602 mg/kg N/R AIPTAK 62,330,1939
intravenous
rabbit
lowest published lethal dose: 576 mg/kg N/R AIPTAK 62,330,1939
oral
rat
lethal dose (50 percent kill): 1,790 mg/kg N/R MarJV# 29MAR1977
oral
rat
lowest published toxic dose: 895 mg/kg Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 180,5,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.05 mg(Cr)/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (production), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (welding fumes), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg(Cr)/m3, APR2007
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.01 mg/m3, short term exposure limit 0.03 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Cr)/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9134;
Number of Industries 1;
Total Number of Facilities 41;
Number of Occupations 2;
Total Number of Employees Exposed 573;
Total Number of Female Employees Exposed 203


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice, Czechoslavakia, Mar. 29, 1977
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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