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Chromium (III) chloride (1:3)

RTECS #: GB5425000

CAS #: 10025-73-7


UPDATE: May 2009 MW: 158.35 MF: Cl3Cr


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. C.I. 77295
  2. Chromic chloride
  3. Chromium chloride
  4. Chromium trichloride
  1. Chromium (III) chloride, anhydrous
  2. Puratronic chromium chloride
  3. Trichlorochromium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 50 g/L CARYAB 32,379,1979
cytogenetic analysis human lymphocyte 2,500 g/L MUREAV 191,207,1987
cytogenetic analysis human fibroblast 100 mol/L CARYAB 32,379,1979
cytogenetic analysis human other cell types 500 mg/L BJCAAI 44,219,1981
DNA damage human lymphocyte 600 mol/L MUREAV 469,135,2000
DNA inhibition mouse fibroblast 300 mol/L JTEHD6 15,237,1985
unscheduled DNA synthesis human fibroblast 100 mol/L DCTODJ 4,185,1981
mutation in microorganisms Salmonella typhimurium 2 mol/plate (+enzymatic activation step) EESADV 9,92,1985
mutation in microorganisms Saccharomyes cerevisiae 80 mmol/L (+/-enzymatic activation step) TECSDY 13,103,1986
micronucleus test human fibroblast 1 mol/L/24 hour MUREAV 490,99,2001
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 mmol/L TECSDY 13,103,1986
other mutation test systems Bacillus subtilis 30 mol/L BECTA6 43,254,1989
phage inhibition capacity Escherichia coli 500 mol/L ENMUDM 6,59,1984
sister chromatid exchange hamster fibroblast 1 mg/L MUREAV 104,141,1982
specific locus test hamster ovary 0.5 mmol/L/48 hour MUREAV 513,135,2002
sperm morphology oral
rat
45,750 g/kg/26 week- continuous GISAAA 50(7),31,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 44,600 g/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
JTSCDR 1(2),1,1976
intraperitoneal
mouse
lowest published toxic dose: 30 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTSCDR 1(2),1,1976
intraperitoneal
mouse
lowest published toxic dose: 59,500 g/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JTSCDR 1(2),1,1976
intraperitoneal
mouse
lowest published toxic dose: 59,500 g/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) JTSCDR 1(2),1,1976
intraperitoneal
mouse
lowest published toxic dose: 158.35 mg/kg (1 day male) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOXID9 78,337,2004
intratesticular
rat
lowest published toxic dose: 12,668 g/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intravenous
hamster
lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities VCVN5* -,301,1989
oral
mouse
lowest published toxic dose: 84 gm/kg (12 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXCYAC 116,39,1997
oral
mouse
lowest published toxic dose: 33,600 mg/kg (12 week prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TXCYAC 116,39,1997
subcutaneous
mouse
lowest published toxic dose: 450 mg/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 12,198,1975
subcutaneous
mouse
lowest published toxic dose: 12,668 g/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
unreported route
mouse
lowest published toxic dose: 158.35 mg/kg (1 day male) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 60,205,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 31,500 g/m3/2 hour N/R 85GMAT -,39,1982
inhalation
mouse
lethal concentration (50 percent kill): 31.5 mg/m3 N/R VCVN5* -,301,1993
intramuscular
mouse
lethal dose (50 percent kill): 40 mg/kg N/R 85GMAT -,39,1982
intraperitoneal
guinea pig
lowest published lethal dose: 200 mg/kg N/R AEHLAU 11,201,1965
intraperitoneal
mouse
lethal dose (50 percent kill): 143 mg/kg N/R COREAF 256,1043,1963
intravenous
mouse
lowest published lethal dose: 400 mg/kg N/R AQMOAC #70-15,1970
intravenous
rabbit
lowest published lethal dose: 288 mg/kg N/R EQSSDX 1,1,1975
oral
rat
lethal dose (50 percent kill): 440 mg/kg N/R VCVN5* -,301,1993
subcutaneous
mouse
lowest published lethal dose: 800 mg/kg N/R AQMOAC #70-15,1970
subcutaneous
mouse
lethal dose (50 percent kill): 7.8 mg/kg N/R VCVN5* -,301,1993
skin
guinea pig
lowest published lethal dose: 202 mg/kg N/R AEHLAU 11,201,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 450 mg/kg/3 day- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
WDZAEK 6,205,1992
oral
chicken
lowest published toxic dose: 4.9 mg/kg/28 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JAPTO* 22,161,2002
oral
mouse
lowest published toxic dose: 33,600 mg/kg/12 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXCYAC 116,39,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
85DHAX Cr,22,1974
TOXICOLOGY REVIEW
CRTXB2 33,215,2003
TOXICOLOGY REVIEW
MUREAV 533,36,2003
TOXICOLOGY REVIEW
HBTME* ,487,2007
TOXICOLOGY REVIEW
HBTME* ,213,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.05 mg(Cr)/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (production), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (welding fumes), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg(Cr)/m3, APR2007
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Cr)/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84456;
Number of Industries 2;
Total Number of Facilities 32;
Number of Occupations 3;
Total Number of Employees Exposed 268
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84456;
Number of Industries 4;
Total Number of Facilities 338;
Number of Occupations 9;
Total Number of Employees Exposed 3,273;
Total Number of Female Employees Exposed 1,706


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for production of solutions of basic chlorides and as a catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used for production of solutions of basic chlorides and as a catalyst

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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