Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Chromic acid, lead(2+) salt (1:1)

RTECS #

GB2975000

CAS #

7758-97-6; 8049-64-7

Updated

September 201

Molecular Weight

323.19

Molecular Formula

CrO4·Pb

Synonyms

Chromate de plomb (French)
Lead chromate
Lead chromate (ACGIH)
Lead chromate(VI)
Lead chromium oxide
Plumbous chromate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human13 µmol/LMUREAV 77,157,1980
Cytogenetic Analysisother cell types/human500 mg/LBJCAAI 44,219,1981
Cytogenetic Analysisovary/hamster5 mg/LBJCAAI 44,219,1981
Cytogenetic Analysisovary/hamster0.1 µg/cm2TOXID9 44,232,2005
Cytogenetic Analysislung/human0.5 µg/plate/24HMUREAV 610,2,2006
Cytogenetic Analysisfibroblast/human0.5 mg/well/24HMUREAV 610,8,2006
Cytogenetic Analysisovary/hamster1 µg/well/24HMUREAV 626,120,2007
DNA Damagefibroblast/human0.5 µg/cm2/24HMUREAV 586,160,2005
DNA Damageovary/hamster350 µmol/L/24HTXAPA9 146,270,1997
DNA Damageovary/hamster1 µmol/LMUREAV 280,129,1992
DNA inhibitionkidney/hamster150 mg/LBJCAAI 44,219,1981
gene conversion and mitotic recombination/Saccharomyes cerevisiae62500 µg/LMUREAV 66,357,1979
micronucleus testintraperitoneal/mouse500 mg/kgTJEMAO 146,373,1985
morphological transformfibroblast/mouse25 µmol/LCNREA8 48,5280,1988
morphological transformkidney/hamster156 mg/LTECSDY 12,185,1986
morphological transformembryo/hamster40 µmol/LCNREA8 39,193,1979
morphological transformfibroblast/human500 nmol/LCNREA8 47,3815,1987
mutation in mammalian somatic cellsovary/hamster8 µmol/LCRNGDP 13,2053,1992
mutation in microorganisms/Salmonella typhimurium200 µg/plate (+/-enzymatic activation step)MUREAV 66,357,1979
mutation in microorganisms/Escherichia coli2 µmol/L (-enzymatic activation step)MUREAV 91,33,1981
other mutation test systemsother cell types/human500 mg/LBJCAAI 44,219,1981
other mutation test systemskidney/hamster150 mg/LBJCAAI 44,219,1981
sister chromatid exchangelymphocyte/human20 µmol/LMUREAV 77,157,1980
sister chromatid exchangeovary/hamster100 µg/LMUREAV 156,219,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 324 mg/kg/39W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Tumors at site of application
CNREA8 36,1779,1976
subcutaneous/rat toxic dose: 135 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
PBPHAW 14,47,1978
subcutaneous/rat lowest published toxic dose: 135 mg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
TUMOAB 57,213,1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lethal dose (75 percent kill): 156 mg/kg85KYAH 11,852,1989
oral/mouse lethal dose (50 percent kill): >12 gm/kgOYYAA2 2,76,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 11250 mg/kg/90D- continuousBehavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,160,1976
oral/rat lowest published toxic dose: 108 gm/kg/90D- continuousKidney, Ureter, and Bladder: Other changes

Blood: Other changes

Blood: Changes in leukocyte (WBC) count
NTIS** OTS0571260

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.012 mg(Cr)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg(Pb)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 49,49,1990
TOXICOLOGY REVIEWENTOX* -,602,2005
TOXICOLOGY REVIEWMUREAV 533,36,2003
TOXICOLOGY REVIEWHBTME* ,487,2007
TOXICOLOGY REVIEWIMEMDT 87,225,

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(Cr)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(Cr)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg(Cr)/m3, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.012 mg(Cr)/m3, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg(Pb)/m3, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 mg(Cr)/m3, MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg(Pb)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-FRANCEVME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-FRANCEVME 0.1 mg(Pb)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Cr)/m3, a2 sen, s1 sen, MAY2012
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Pb)/m3, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(Cr)/m3, JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(CrO3)/m3, JAN1999
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.012 mg(Cr)/m3, 0.05 mg(Pb)/m3, JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.005 mg(Cr)/m3;short term exposure limit 0.015 mg(Cr)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Cr)/m3, carc 1, inhal, skin, sen, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Pb)/m3, KZG-week 0.8 mg(Pb)/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 mg(Cr)/m3, carc, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air10H Carcinogen time-weighted average 0.001 mg(Cr)/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air10H time-weighted average <0.1 mg(Pb)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 81876; Number of Industries 33; Total Number of Facilities 1628; Number of Occupations 28; Total Number of Employees Exposed 31932; Total Number of Female Employees Exposed 8639
National Occupational Hazard Survey 1974Hazard Code 81876; Number of Industries 173; Total Number of Facilities 12060; Number of Occupations 87; Total Number of Employees Exposed 131959

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 4, 1975/1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
TOP