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Chromic acid, disodium salt

RTECS #: GB2955000

CAS #: 7775-11-3


UPDATE: May 2009 MW: 161.98 MF: CrO4•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chromate of soda
  2. Chromium disodium oxide
  3. Chromium sodium oxide (CrNa2O4)
  4. Disodium chromate
  1. Neutral sodium chromate
  2. Sodium chromate
  3. Sodium chromate (VI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 2,500 nmol/L MUREAV 260,19,1991
cytogenetic analysis hamster ovary 250 µg/L TXCYAC 17,219,1980
cytogenetic analysis hamster ovary 2.5 µmol/L/24 hour MUREAV 610,31,2006
cytogenetic analysis human fibroblast 0.5 µmol/L/24 hour MUREAV 560,79,2004
cytogenetic analysis human lung 0.5 µmol/L TOXID9 66,32,2002
cytogenetic analysis human lung 1 µmol/L/24 hour MUREAV 610,2,2006
DNA damage chicken embryo 2,500 nmol/L CRNGDP 4,959,1983
DNA damage hamster lung 200 µmol/L/2 hour- continuous CNREA8 48,1100,1988
DNA damage human fibroblast 1 µmol/L/24 hour MUREAV 586,160,2005
DNA damage inhalation
rat
0.18 mg/m3/6 hour MUREAV 539,109,2003
DNA repair Bacillus subtilis 50 mmol/L TOLED5 7,439,1981
DNA repair inhalation
rat
0.9 mg/m3/6 hour MUREAV 539,109,2003
DNA repair Salmonella typhimurium 50 mmol/L TOLED5 7,439,1981
mutation in microorganisms Escherichia coli 50 nmol/plate (-enzymatic activation step) NATUAS 250,493,1974
mutation in microorganisms Saccharomyes cerevisiae 25 mmol/L (-enzymatic activation step) TECSDY 23,101,1989
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L TECSDY 23,101,1989
mutation in mammalian somatic cells hamster lung 2,500 nmol/L MUREAV 260,19,1991
sister chromatid exchange hamster ovary 250 µg/L TXCYAC 17,219,1980
sister chromatid exchange hamster lung 32 µg/L CRNGDP 4,605,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 5 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOLED5 51,269,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intradermal
guinea pig
lowest published lethal dose: 382 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
JAPHAR 11,285,1877
intradermal
rabbit
lowest published lethal dose: 250 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes
JAPHAR 11,285,1877
intraperitoneal
guinea pig
lowest published lethal dose: 206 mg/kg N/R AEHLAU 11,201,1965
intraperitoneal
mouse
lethal dose (50 percent kill): 32 mg/kg N/R COREAF 257,791,1963
intraperitoneal
rat
lethal dose (50 percent kill): 57 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma
AIPTAK 154,243,1965
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition FCTOD7 44,1006,2006
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria
HBTME* -,487,2007
intravenous
cat
lethal dose (50 percent kill): 164 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
AGSOA6 8,51,1967
intravenous
dog
lowest published lethal dose: 235 mg/kg N/R EQSSDX 1,1,1975
intravenous
rabbit
lowest published lethal dose: 32 mg/kg N/R EQSSDX 1,1,1975
oral
rat
lethal dose (50 percent kill): 136 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Skin and Appendages: Other: Hair
IJTOFN 19,338,2000
subcutaneous
guinea pig
lowest published lethal dose: 30 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
rabbit
lowest published lethal dose: 243 mg/kg N/R EQSSDX 1,1,1975
skin
guinea pig
lowest published lethal dose: 206 mg/kg N/R AEHLAU 11,201,1965
unreported route
rat
lowest published toxic dose: 25 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 44,104,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Cr)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
85DHAX Cr,22,1974
TOXICOLOGY REVIEW
HBTME* ,487,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(Cr)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.05 mg(Cr)/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (production), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (welding fumes), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg(Cr)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Cr)/m3, APR2007
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg(Cr)/m3, sen, JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.005 mg(Cr)/m3;
short term exposure limit 0.015 mg(Cr)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Cr)/m3, Carcinogen, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air Carcinogen;
10 hour time-weighted average 0.001 mg(Cr)/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68900;
Number of Industries 69;
Total Number of Facilities 3,942;
Number of Occupations 48;
Total Number of Employees Exposed 34,156
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68900;
Number of Industries 66;
Total Number of Facilities 3,561;
Number of Occupations 59;
Total Number of Employees Exposed 80,015;
Total Number of Female Employees Exposed 3,487


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in leather tanning, wood preservation, corrosion inhibition and pigment manufacture
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1960-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBTME*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPHAR Journal of Anatomy and Physiology. (London, UK) V.1-50, 1916. For publisher information, see JOANAY.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in leather tanning, wood preservation, corrosion inhibition and pigment manufacture

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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