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Registry of Toxic Effects of Chemical Substances (RTECS)

Chromic acid, disodium salt

RTECS #

GB2955000

CAS #

7775-11-3

Updated

July 2013

Molecular Weight

161.98

Molecular Formula

CrO4·2Na

Synonyms

Chromate of soda
Chromium disodium oxide
Chromium sodium oxide (CrNa2O4)
Disodium chromate
Neutral sodium chromate
Sodium chromate
Sodium chromate(VI)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster2500 nmol/LMUREAV 260,19,1991
Cytogenetic Analysisovary/hamster250 µg/LTXCYAC 17,219,1980
Cytogenetic Analysisfibroblast/human0.5 µmol/L/24HMUREAV 560,79,2004
Cytogenetic Analysislung/human0.5 µmol/LTOXID9 66,32,2002
Cytogenetic Analysislung/human1 µmol/L/24HMUREAV 610,2,2006
Cytogenetic Analysisovary/hamster2.5 µmol/L/24HMUREAV 610,31,2006
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 586,160,2005
DNA Damagelung/hamster200 µmol/L/2H-continuousCNREA8 48,1100,1988
DNA Damageembryo/chicken2500 nmol/LCRNGDP 4,959,1983
DNA Damageinhalation/rat0.18 mg/m3/6HMUREAV 539,109,2003
DNA repairinhalation/rat0.9 mg/m3/6HMUREAV 539,109,2003
DNA repair/Salmonella typhimurium50 mmol/LTOLED5 7,439,1981
DNA repair/Bacillus subtilis50 mmol/LTOLED5 7,439,1981
gene conversion and mitotic recombination/Saccharomyes cerevisiae25 mmol/LTECSDY 23,101,1989
mutation in mammalian somatic cellslung/hamster2500 nmol/LMUREAV 260,19,1991
mutation in microorganisms/Saccharomyes cerevisiae25 mmol/L (-enzymatic activation step)TECSDY 23,101,1989
mutation in microorganisms/Escherichia coli50 nmol/plate (-enzymatic activation step)NATUAS 250,493,1974
sister chromatid exchangeovary/hamster250 µg/LTXCYAC 17,219,1980
sister chromatid exchangelung/hamster32 µg/LCRNGDP 4,605,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 5 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOLED5 51,269,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intradermal/guinea pig lowest published lethal dose: 382 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
JAPHAR 11,285,1877
intradermal/rabbit lowest published lethal dose: 250 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes
JAPHAR 11,285,1877
intraperitoneal/guinea pig lowest published lethal dose: 206 mg/kgAEHLAU 11,201,1965
intraperitoneal/mouse lethal dose (50 percent kill): 32 mg/kgCOREAF 257,791,1963
intraperitoneal/rat lethal dose (50 percent kill): 57 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma
AIPTAK 154,243,1965
intraperitoneal/rat lowest published toxic dose: 20 mg/kgKidney, Ureter, and Bladder: Other changes in urine compositionFCTOD7 44,1006,2006
intraperitoneal/rat lowest published toxic dose: 10 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria
HBTME* -,487,2007
intravenous/cat lethal dose (50 percent kill): 164 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
AGSOA6 8,51,1967
intravenous/Dog lowest published lethal dose: 235 mg/kgEQSSDX 1,1,1975
intravenous/rabbit lowest published lethal dose: 32 mg/kgEQSSDX 1,1,1975
oral/rat lethal dose (50 percent kill): 136 mg/kgBehavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Skin and Appendages: Other: Hair
IJTOFN 19,338,2000
skin/guinea pig lowest published lethal dose: 206 mg/kgAEHLAU 11,201,1965
subcutaneous/guinea pig lowest published lethal dose: 30 mg/kgEQSSDX 1,1,1975
subcutaneous/rabbit lowest published lethal dose: 243 mg/kgEQSSDX 1,1,1975
unreported route/rat lowest published toxic dose: 25 mg/kgKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 44,104,2005

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 49,49,1990
TOXICOLOGY REVIEW85DHAX Cr,22,1974
TOXICOLOGY REVIEWHBTME* ,487,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(Cr)/m3DTLVS* 3,35,1971
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(Cr)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg(Cr)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 mg(Cr)/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.05 mg(CrO4)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Cr)/m3, a2 sen, s1 sen, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(Cr)/m3, sen, JAN2002
Occupational Exposure Limit-SWEDENtime-weighted average 0.005 mg(Cr)/m3;short term exposure limit 0.015 mg(Cr)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Cr)/m3, carc 1, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 mg(Cr)/m3, carc, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.1 mg(CrO3)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air10H Carcinogen time-weighted average 0.001 mg(Cr)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 68900; Number of Industries 66; Total Number of Facilities 3561; Number of Occupations 59; Total Number of Employees Exposed 80015; Total Number of Female Employees Exposed 3487
National Occupational Hazard Survey 1974Hazard Code 68900; Number of Industries 69; Total Number of Facilities 3942; Number of Occupations 48; Total Number of Employees Exposed 34156

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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