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Chloric acid, sodium salt

RTECS #: FO0525000

CAS #: 7775-09-9

UPDATE: February 2009 MW: 106.44 MF: ClO3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Agrosan
  2. Asex
  3. Atlacide
  4. Atratol
  5. B - Herbatox
  6. Chlorate de sodium
  7. Chlorate salt of sodium
  8. Desolet
  9. Drexel defol
  10. Evau - super
  11. Grain sorghum harvest - aid
  12. Granex O
  13. Harvest - aid
  14. Hibar C
  15. Kusa - tohru
  16. Kusatol
  1. Leafex 2
  2. Natriumchloraat (Dutch)
  3. Natriumchlorat (German)
  4. Ortho C - 1 defoliant & weed killer
  5. Oxycil
  6. Rasikal
  7. Shed - A - leaf
  8. Soda chlorate
  9. Sodakem
  10. Sodio (clorato di) (Italian)
  11. Sodium chlorate
  12. Sodium (chlorate de) (French)
  13. Travex
  14. Tumbleaf
  15. United Chemical Defoliant No. 1
  16. VAL - DROP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition oral
rat 		84 mg/kg/12 week- continuous JEPOEC 6(1),105,1985
mutation in microorganisms Salmonella typhimurium 40 µmol/plate (-enzymatic activation step) MUREAV 90,91,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		250 mmol/L MUREAV 90,91,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 596 mg/kg N/R HBPTO* 2,1412,2001
oral
cat 		lowest published lethal dose: 1,350 mg/kg N/R PCOC** -,1013,1966
oral
cat 		lethal dose (50 percent kill): 1,350 mg/kg N/R VCVN5* -,384,1989
oral
dog 		lowest published lethal dose: 700 mg/kg N/R HBAMAK 4,1289,1935
oral
dog 		lethal dose (50 percent kill): 700 mg/kg N/R VCVN5* -,384,1989
oral
guinea pig 		lethal dose (50 percent kill): 6,100 mg/kg N/R VCVN1* -,36,1998
oral
human 		lowest published lethal dose: 107.14 mg/kg N/R HBPTO* 2,1412,2001
oral
human 		lowest published toxic dose: 5.7 mg/kg Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed 		VCVN5* -,384,1989
oral
man 		lowest published toxic dose: 286 mg/kg Lung, Thorax, or Respiration: Cyanosis

Blood: Changes in cell count (unspecified)

Blood: Methemoglobinemia- Carboxhemoglobinemia 		CTOXAO 15,185,1979
oral
mouse 		lethal dose (50 percent kill): 3,600 mg/kg N/R VCVN1* -,36,1998
oral
rat 		lethal dose (50 percent kill): 1,200 mg/kg N/R HBPTO* 2,1412,2001
oral
rabbit 		lethal dose (50 percent kill): 7,200 mg/kg N/R GTPZAB 31(1),49,1987
oral
woman 		lowest published toxic dose: 800 mg/kg Lung, Thorax, or Respiration: Other changes

Blood: Other hemolysis with or without anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia 		34ZIAG -,539,1969
unreported route
child 		lethal dose (50 percent kill): 185 mg/kg N/R GUCHAZ 6,461,1973
unreported route
human 		lowest published lethal dose: 214 mg/kg N/R GUCHAZ 6,461,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 1,630 mg/kg/5 day- intermittent Behavioral: Food intake (animal)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VETRAX 90,416,1972
oral
mouse 		lowest published toxic dose: 17,640 mg/kg/84 week- intermittent Gastrointestinal: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* TR-517
oral
mouse 		lowest published toxic dose: 87,600 mg/kg/2 year- intermittent Endocrine: Other changes NTPTR* TR-517
oral
mouse 		lowest published toxic dose: 21,900 mg/kg/2 year- intermittent Blood: Changes in bone marrow not included in above NTPTR* TR-517
oral
rat 		lowest published toxic dose: 495 mg/kg/1 year- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPOEC 6(1),105,1985
oral
rat 		lowest published toxic dose: 58,819 mg/kg/13 week- continuous Brain and Coverings: Changes in brain weight

Endocrine: Other changes

Blood: Changes in erythrocyte (RBC) count 		DCTODJ 18,185,1995
oral
rat 		lowest published toxic dose: 80 mg/kg/4 day- intermittent Blood: Changes in leukocyte (WBC) count NTPTR* TR-517
oral
rat 		lowest published toxic dose: 6,300 mg/kg/3 week- intermittent Cardiac: Changes in heart weight NTPTR* TR-517
oral
rat 		lowest published toxic dose: 1,575 mg/kg/3 week- intermittent Endocrine: Other changes NTPTR* TR-517
oral
rat 		lowest published toxic dose: 140 mg/kg/4 day- intermittent Endocrine: Evidence of thyroid hypofunction NTPTR* TR-517
oral
rat 		lowest published toxic dose: 375 mg/kg/3 week- intermittent Endocrine: Other changes

Endocrine: Thyroid tumors

Blood: Changes in bone marrow not included in above 		NTPTR* TR-517
oral
rat 		lowest published toxic dose: 945 mg/kg/3 week- intermittent Endocrine: Other changes

Endocrine: Thyroid tumors 		NTPTR* TR-517
oral
rat 		lowest published toxic dose: 1,575 mg/kg/3 week- intermittent Blood: Changes in spleen NTPTR* TR-517
oral
rat 		lowest published toxic dose: 838,600 µg/kg/7 day- continuous Endocrine: Thyroid weight (goiter)

Endocrine: Other changes 		TOPADD 33,776,2005
oral
rat 		lowest published toxic dose: 23,170 µg/kg/7 day- continuous Endocrine: Thyroid weight (goiter) TOPADD 33,776,2005
oral
rabbit 		lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Behavioral: Food intake (animal) NTPTR* TER-97005
oral
rabbit 		lowest published toxic dose: 100 mg/kg/1 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTPTR* TER-97005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
JFSCAS 45,474,2000
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,316,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68870;
Number of Industries 15;
Total Number of Facilities 334;
Number of Occupations 14;
Total Number of Employees Exposed 3,058
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68870;
Number of Industries 35;
Total Number of Facilities 1,023;
Number of Occupations 34;
Total Number of Employees Exposed 28,583;
Total Number of Female Employees Exposed 5,207


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a constituent of ATRATOL and PRAMITOL
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888-

Used as a constituent of ATRATOL and PRAMITOL

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 11096-45-0
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