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Registry of Toxic Effects of Chemical Substances (RTECS)

Chloric acid, sodium salt

RTECS #

FO0525000

CAS #

7775-09-9; 11096-45-0

Updated

October 2010

Molecular Weight

106.44

Molecular Formula

ClO3·Na

Synonyms

Agrosan
Asex
Atlacide
Atratol
B-Herbatox
Chlorate de sodium
Chlorate salt of sodium
Desolet
Drexel defol
Evau-super
Grain sorghum harvest-aid
Granex O
Harvest-aid
Hibar C
Kusa-tohru
Kusatol
Leafex 2
Natriumchloraat (Dutch)
Natriumchlorat (German)
Ortho C-1 defoliant & weed killer
Oxycil
Rasikal
Shed-A-leaf
Soda chlorate
Sodakem
Sodio (clorato di) (Italian)
Sodium chlorate
Sodium(chlorate de) (French)
Travex
Tumbleaf
United Chemical Defoliant No. 1
VAL-DROP

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionoral/rat84 mg/kg/12W-continuousJEPOEC 6(1),105,1985
mutation in microorganisms/Salmonella typhimurium40 µmol/plate (-enzymatic activation step)MUREAV 90,91,1981
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster250 mmol/LMUREAV 90,91,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 596 mg/kgHBPTO* 2,1412,2001
oral/cat lethal dose (50 percent kill): 1350 mg/kgVCVN5* -,384,1989
oral/cat lowest published lethal dose: 1350 mg/kgPCOC** -,1013,1966
oral/Dog lowest published lethal dose: 700 mg/kgHBAMAK 4,1289,1935
oral/Dog lethal dose (50 percent kill): 700 mg/kgVCVN5* -,384,1989
oral/guinea pig lethal dose (50 percent kill): 6100 mg/kgVCVN1* -,36,1998
oral/human lowest published lethal dose: 107.14 mg/kgHBPTO* 2,1412,2001
oral/human lowest published toxic dose: 5.7 mg/kgVascular: BP lowering not characterized in autonomic section

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
VCVN5* -,384,1989
oral/man lowest published toxic dose: 286 mg/kgLung, Thorax, or Respiration: Cyanosis

Blood: Changes in cell count (unspecified)

Blood: Methemoglobinemia- Carboxhemoglobinemia
CTOXAO 15,185,1979
oral/mouse lethal dose (50 percent kill): 3600 mg/kgVCVN1* -,36,1998
oral/rabbit lethal dose (50 percent kill): 7200 mg/kgGTPZAB 31(1),49,1987
oral/rat lethal dose (50 percent kill): 1200 mg/kgHBPTO* 2,1412,2001
oral/woman lowest published toxic dose: 800 mg/kgLung, Thorax, or Respiration: Other changes

Blood: Other hemolysis with or without anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia
34ZIAG -,539,1969
unreported route/child lethal dose (50 percent kill): 185 mg/kgGUCHAZ 6,461,1973
unreported route/human lowest published lethal dose: 214 mg/kgGUCHAZ 6,461,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1630 mg/kg/5D- intermittentBehavioral: Food intake (animal)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VETRAX 90,416,1972
oral/mouse lowest published toxic dose: 17640 mg/kg/84W- intermittentGastrointestinal: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-517
oral/mouse lowest published toxic dose: 87600 mg/kg/2Y- intermittentEndocrine: Other changesNTPTR* TR-517
oral/mouse lowest published toxic dose: 21900 mg/kg/2Y- intermittentBlood: Changes in bone marrow not included in aboveNTPTR* TR-517
oral/rabbit lowest published toxic dose: 1000 mg/kg/4D- intermittentBehavioral: Food intake (animal)NTPTR* TER-97005
oral/rabbit lowest published toxic dose: 100 mg/kg/1D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Other changes in urine composition
NTPTR* TER-97005
oral/rat lowest published toxic dose: 80 mg/kg/4D- intermittentBlood: Changes in leukocyte (WBC) countNTPTR* TR-517
oral/rat lowest published toxic dose: 6300 mg/kg/3W- intermittentCardiac: Changes in heart weightNTPTR* TR-517
oral/rat lowest published toxic dose: 1575 mg/kg/3W- intermittentEndocrine: Other changesNTPTR* TR-517
oral/rat lowest published toxic dose: 140 mg/kg/4D- intermittentEndocrine: Evidence of thyroid hypofunctionNTPTR* TR-517
oral/rat lowest published toxic dose: 375 mg/kg/3W- intermittentEndocrine: Other changes

Endocrine: Thyroid tumors

Blood: Changes in bone marrow not included in above
NTPTR* TR-517
oral/rat lowest published toxic dose: 945 mg/kg/3W- intermittentEndocrine: Other changes

Endocrine: Thyroid tumors
NTPTR* TR-517
oral/rat lowest published toxic dose: 1575 mg/kg/3W- intermittentBlood: Changes in spleenNTPTR* TR-517
oral/rat lowest published toxic dose: 838600 µg/kg/7D- continuousEndocrine: Thyroid weight (goiter)

Endocrine: Other changes
TOPADD 33,776,2005
oral/rat lowest published toxic dose: 23170 µg/kg/7D- continuousEndocrine: Thyroid weight (goiter)TOPADD 33,776,2005
oral/rat lowest published toxic dose: 495 mg/kg/1Y- continuousBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPOEC 6(1),105,1985
oral/rat lowest published toxic dose: 58819 mg/kg/13W- continuousBrain and Coverings: Changes in brain weight

Endocrine: Other changes

Blood: Changes in erythrocyte (RBC) count
DCTODJ 18,185,1995

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJAVMA4 164,277,1974
TOXICOLOGY REVIEWJFSCAS 45,474,2000
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWFEREAC 74,22478,2009
TOXICOLOGY REVIEWFEREAC 74,47451,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,316,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 68870; Number of Industries 35; Total Number of Facilities 1023; Number of Occupations 34; Total Number of Employees Exposed 28583; Total Number of Female Employees Exposed 5207
National Occupational Hazard Survey 1974Hazard Code 68870; Number of Industries 15; Total Number of Facilities 334; Number of Occupations 14; Total Number of Employees Exposed 3058

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000
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