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Registry of Toxic Effects of Chemical Substances (RTECS)

Castor oil

RTECS #

FI4100000

CAS #

8001-79-4; 8021-37-2

Updated

October 2010

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Aromatic castor oil
Castor oil aromatic
Cosmetol
Crystal O
Gold bond
NCI-C55163
Neoloid
Oil of Palma christi
Phorbyol
Ricinus oil
Ricirus oil
Tangantangan oil

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
skin /guinea pig 100 mg/24H mildCTOIDG 94(8),41,1979
skin /man 50 mg/48H mildCTOIDG 94(8),41,1979
skin /rabbit 100 mg/24H severeCTOIDG 94(8),41,1979
skin /rat 100 mg/24H mildCTOIDG 94(8),41,1979

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intramuscular/rat 1 mL/kg (1D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EKFAE9 57,49,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 1 mL/kgEndocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Uterus, cervix, vagina
EKFAE9 57,49,1994
oral/mouse lowest published toxic dose: 4 mL/kgGastrointestinal: Hypermotility, diarrheaPYTOEY 12,670,2005
oral/rat lowest published toxic dose: 4 mL/kgGastrointestinal: Hypermotility, diarrheaFTRPAE 81,72,2010

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 675 gm/kg/90D- intermittentLiver: Changes in liver weightHPV282 -,-,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 44,1689,2006
TOXICOLOGY REVIEWPYTOEY 9,352,2002
TOXICOLOGY REVIEWBPRCG* 21,849,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,358,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1030; Number of Industries 195; Total Number of Facilities 32342; Number of Occupations 136; Total Number of Employees Exposed 444011; Total Number of Female Employees Exposed 172359
National Occupational Hazard Survey 1974Hazard Code M1030; Number of Industries 259; Total Number of Facilities 34810; Number of Occupations 134; Total Number of Employees Exposed 487959

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-12, October 2000
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