CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Castor oil

RTECS #: FI4100000

CAS #: 8001-79-4


UPDATE: November 2008 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Aromatic castor oil
  2. Castor oil aromatic
  3. Cosmetol
  4. Crystal O
  5. Gold bond
  6. NCI - C55163
  1. Neoloid
  2. Oil of Palma christi
  3. Phorbyol
  4. Ricinus oil
  5. Ricirus oil
  6. Tangantangan oil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg mild AJOPAA 29,1363,1946
skin
guinea pig
100 mg/24 hour mild CTOIDG 94(8),41,1979
skin
man
50 mg/48 hour mild CTOIDG 94(8),41,1979
skin
rat
100 mg/24 hour mild CTOIDG 94(8),41,1979
skin
rabbit
100 mg/24 hour severe CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 1 mL/kg (1 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EKFAE9 57,49,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 1 mL/kg Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Uterus, cervix, vagina
EKFAE9 57,49,1994
oral
mouse
lowest published toxic dose: 9.52 mL/kg Gastrointestinal: Hypermotility, diarrhea BJPCBM 148,553,2006
oral
rat
lowest published toxic dose: 4 mL/kg Gastrointestinal: Hypermotility, diarrhea INJPD2 38,346,2006


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FCTOD7 44,1689,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,358,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1030;
Number of Industries 259;
Total Number of Facilities 34,810;
Number of Occupations 134;
Total Number of Employees Exposed 487,959
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1030;
Number of Industries 195;
Total Number of Facilities 32,342;
Number of Occupations 136;
Total Number of Employees Exposed 444,011;
Total Number of Female Employees Exposed 172,359


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, cosmetic, perfume ingredient, pharmaceutical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-12, October 2000


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a chemical intermediate, cosmetic, perfume ingredient, pharmaceutical

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

ALT CAS #: 8021-37-2
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us