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Carbonochloridic acid, methyl ester

RTECS #: FG3675000

CAS #: 79-22-1


UPDATE: February 2008 MW: 94.50 MF: C2H3ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chlorameisensaeure methylester (German)
  2. Chlorocarbonate de methyle (French)
  3. Chlorocarbonic acid methyl ester
  4. Chloroformiate de methyle (French)
  5. Chloroformic acid methyl ester
  6. Formic acid, chloro - , methyl ester
  7. MCF
  8. Methoxycarbonyl chloride
  1. Methyl chlorocarbonate
  2. Methylchloorformiaat (Dutch)
  3. Methylester kyseliny chlormravenci (Czech)
  4. Methylester kyseliny chloruhlicite (Czech)
  5. Metilcloroformiato (Italian)
  6. RCRA waste number U156
  7. TL 438


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 1,500 mg/m3/30 minute N/R GISAAA 42(5),97,1977
inhalation
man
lowest published toxic concentration: 5 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
GISAAA 42(5),97,1977
inhalation
mouse
lethal concentration (50 percent kill): 185 mg/m3/2 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Muscle weakness
GISAAA 42(5),97,1977
inhalation
rat
lethal concentration (50 percent kill): 88 ppm/1 hour N/R TXAPA9 42,417,1977
intraperitoneal
mouse
lethal dose (50 percent kill): 40 mg/kg N/R NTIS** AD691-490
oral
guinea pig
lethal dose (50 percent kill): 140 mg/kg N/R GISAAA 42(5),97,1977
oral
mouse
lethal dose (50 percent kill): 67 mg/kg N/R GISAAA 42(5),97,1977
oral
rat
lethal dose (50 percent kill): 60 mg/kg N/R GISAAA 42(5),97,1977
skin
mouse
lethal dose (50 percent kill): 1,750 mg/kg N/R GISAAA 42(5),97,1977
skin
rabbit
lethal dose (50 percent kill): 7,120 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 640 g/m3/17 week- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 42(5),97,1977
inhalation
rat
lowest published toxic concentration: 34,360 g/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0570775
inhalation
rat
lowest published toxic concentration: 720 g/m3/17 week- intermittent Cardiac: Changes in heart weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 42(5),97,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - GERMANY MAK 0.78 mg/m3 (0.2 mL/m3), 2005
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm (0.78 mg/m3);
KZG- week 0.4 ppm (1.56 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4785;
Number of Industries 2;
Total Number of Facilities 257;
Number of Occupations 4;
Total Number of Employees Exposed 3,949;
Total Number of Female Employees Exposed 408


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of pharmaceuticals, herbicides, plastics and other organic chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in synthesis of pharmaceuticals, herbicides, plastics and other organic chemicals

RTECS Compound Description:
   Human Data

Click Here for Additional Information about RTECS

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