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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbazic acid, 3-(2-quinoxalinylmethylene)-, methyl ester, N(sup 1),N(sup 4)-dioxide

RTECS #

FE2779000

CAS #

6804-07-5; 39310-25-3

Updated

July 2012

Molecular Weight

262.25

Molecular Formula

C11H10N4O4

Synonyms

2-Formylquinoxaline 1,4-dioxide carbomethoxyhydrazone
3-(2-Chinoxalinylmethylen-1,4-dioxid)methylkarbazat (Czech)
Carbadox
Fortigro
Getroxel
GS 6244
Hydrazinecarboxylic acid, (2-quinoxalinylmethylene)-, methyl ester, N,N'-dioxide (9CI)
Karbadox (Czech)
Mecadox
Methyl 3-(2-quinoxalinylmethylene)carbazate-N1,N4-dioxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse100 mg/kgMUREAV 117,311,1983
DNA Damagekidney/monkey5 mg/L/4HFCTOD7 47,328,2009
DNA Damagekidney/monkey5 mg/L/4H (+/-enzymatic activation step)FCTOD7 47,328,2009
DNA inhibitionother cell types/human50 mg/LJTEHD6 10,143,1982
DNA repair/Salmonella typhimurium100 µg/discMUREAV 90,49,1981
DNA repair/Bacillus subtilis1 µg/discMUREAV 90,49,1981
micronucleus testintraperitoneal/rat10 mg/kgMUREAV 116,129,1983
micronucleus testoral/mouse100 mg/kgMUREAV 144,81,1985
micronucleus testintraperitoneal/mouse100 mg/kgMUREAV 144,81,1985
micronucleus testkidney/monkey10 mg/L/24H (+/-enzymatic activation step)FCTOD7 47,328,2009
mutation in microorganisms/Salmonella typhimurium50 nmol/plate (+/-enzymatic activation step)CPBTAL 28,1347,1980
mutation in microorganisms/Escherichia coli2 µg/plate (+enzymatic activation step)MUREAV 217,203,1989
other mutation test systems/Escherichia coli100 µg/LMUREAV 131,101,1984
sister chromatid exchangelung/hamster2 mg/LMUREAV 139,199,1984
Unscheduled DNA Synthesisliver/rat38 µmol/LMUREAV 221,263,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 800 mg/kg (8-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 129,115,2002
oral/rat 200 mg/kg (8-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOLED5 129,115,2002
oral/rat 800 mg/kg (8-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TOLED5 129,115,2002

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 5475 mg/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
IGSBAL 127,283,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Pig, endocrine cell (tissues) Inhibitor Concentration Low: 40 mg/L/1HEndocrine: AldosteronismTIVIEQ 2,141,1988
oral/mouse lethal dose (50 percent kill): 2810 mg/kgCKFRAY 30,26,1981
oral/rat lethal dose (50 percent kill): 850 mg/kgCKFRAY 30,26,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 80 mg/kg/8D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOLED5 129,115,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.003 mg/m3, 2003
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