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Carbanilic acid, m - chloro - , isopropyl ester

RTECS #: FD8050000

CAS #: 101-21-3


UPDATE: February 2009 MW: 213.68 MF: C10H12ClNO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (3 - Chlorophenyl) carbamic acid, 1 - methylethyl ester
  2. 1 - Methylethyl (3 - chlorophenyl) carbamate
  3. 3 - Chlorocarbanilic acid, isopropyl ester
  4. Bud Nip
  5. Bygran
  6. CI - IFK
  7. CIPC
  8. Carbamic acid, (3 - chlorophenyl) - , 1 - methylethyl ester (9CI)
  9. Chlor IFC
  10. Chlor IFK
  11. Chlor IPC
  12. Chloro - IPC
  13. Chloropropham
  14. Chlorpropham
  15. Chlorprophame (French)
  16. ENT 18,060
  17. Elbanil
  18. Fasco WY - hoe
  19. Furloe
  20. Furloe 4EC
  21. Isopropyl meta - chlorocarbanilate
  22. Isopropyl 3 - chlorocarbanilate
  23. Isopropyl - N - m - chlorophenyl - carbamate
  24. Isopropyl 3 - chlorophenylcarbamate
  1. Isopropyl - N - (3 - chlorophenyl) carbamate
  2. Isopropyl - N - (3 - chlorphenyl) - carbamat (German)
  3. Keim - stop
  4. Liro CIPC
  5. Metoxon
  6. Mirvale
  7. N - (3 - Chloor - fenyl) - isopropyl carbamaat (Dutch)
  8. N - (3 - Chloro phenyl) carbamate d'isopropyle (French)
  9. N - (3 - Chlorophenyl) carbamic acid, isopropyl ester
  10. N - (3 - Chlor - phenyl) - isopropyl - carbamat (German)
  11. N - (3 - Cloro - fenil) - isopropil - carbammato (Italian)
  12. Nexoval
  13. O - Isopropyl N - (3 - chlorophenyl) carbamate
  14. Preventol
  15. Preventol 56
  16. Sprout nip
  17. Sprout - nip EC
  18. Stopgerme - S
  19. Taterpex
  20. Triherbicide CIPC
  21. Unicrop CIPC
  22. Y 3
  23. m - Chlorocarbanilic acid, isopropyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis human fibroblast 4 mg/L PMRSDJ 1,528,1981
unscheduled DNA synthesis human lymphocyte 30 mg/L ABILAE 92,367,1981
mutation in microorganisms Saccharomyes cerevisiae 100 mg/L (-enzymatic activation step) PMRSDJ 1,414,1981
mutation in mammalian somatic cells mouse lymphocyte 31,500 g/L PMRSDJ 1,580,1981
morphological transform hamster kidney 2,500 g/L PMRSDJ 1,638,1981
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 25 mg/L PMRSDJ 1,468,1981
specific locus test mouse other cell types 147 mol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 3 gm/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 11,697,1997
subcutaneous
mouse
lowest published toxic dose: 9 gm/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 600 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 12,355,1958


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 2,600 mg/kg N/R CRSBAW 175,496,1981
intraperitoneal
rat
lethal dose (50 percent kill): 700 mg/kg N/R CRSBAW 175,496,1981
oral
mouse
lethal dose (50 percent kill): 3,650 mg/kg N/R FACOEB 16,173,1999
oral
rat
lethal dose (50 percent kill): 1,200 mg/kg Eye: Other eye effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
AEHLAU 19,621,1969
oral
rabbit
lethal dose (50 percent kill): 5 gm/kg N/R PAREAQ 14,225,1962
unreported route
duck
lethal dose (50 percent kill): >2 gm/kg N/R FMCHA2 -,C73,1991
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 3 gm/kg N/R 30ZDA9 -,200,1971
unreported route
rat
lethal dose (50 percent kill): 3,350 mg/kg N/R EQSSDX 3,618,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 789 gm/kg/1 year- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 2,659,1960
oral
rat
lowest published toxic dose: 1,092 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 2,659,1960
oral
rat
lowest published toxic dose: 68,250 mg/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TXCYAC 123,111,1997
oral
rat
lowest published toxic dose: 126 gm/kg/2 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral
rat
lowest published toxic dose: 252 gm/kg/4 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral
rat
lowest published toxic dose: 378 gm/kg/6 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral
rat
lowest published toxic dose: 504 gm/kg/8 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral
rat
lowest published toxic dose: 819 gm/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral
rat
lowest published toxic dose: 3,276 mg/kg/13 week- continuous Blood: Changes in spleen FCTOD7 42,1469,2004
oral
rat
lowest published toxic dose: 16.4 gm/kg/13 week- continuous Endocrine: Changes in spleen weight

Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above
FCTOD7 42,1469,2004
oral
rat
lowest published toxic dose: 81.9 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FCTOD7 42,1469,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,55,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,55,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
FEREAC 71,54953,2006
TOXICOLOGY REVIEW
FEREAC 72,37646,2007
TOXICOLOGY REVIEW
FEREAC 72,37646,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,99,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
Used as a highly selective pre-emergence and early post-emergence herbicide
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ABILAE Archives de Biologie (1880-1985). (Liege, Belgium) V.1-96(1), 1880-1985.
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FACOEB Food Additives and Contaminants. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1984-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a highly selective pre-emergence and early post-emergence herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 11097-02-2
Click Here for Additional Information about RTECS

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