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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbanilic acid, m-chloro-, isopropyl ester

RTECS #

FD8050000

CAS #

101-21-3; 11097-02-2

Updated

February 2009

Molecular Weight

213.68

Molecular Formula

C10H12ClNO2

Synonyms

(3-Chlorophenyl)carbamic acid, 1-methylethyl ester
1-Methylethyl(3-chlorophenyl)carbamate
3-Chlorocarbanilic acid, isopropyl ester
Bud Nip
Bygran
Carbamic acid, (3-chlorophenyl)-, 1-methylethyl ester (9CI)
Chlor IFC
Chlor IFK
Chlor IPC
Chloro-IPC
Chloropropham
Chlorpropham
Chlorprophame (French)
CI-IFK
CIPC
Elbanil
ENT 18,060
Fasco WY-hoe
Furloe
Furloe 4EC
Isopropyl 3-chlorocarbanilate
Isopropyl 3-chlorophenylcarbamate
Isopropyl meta-chlorocarbanilate
Isopropyl-N-(3-chlorophenyl)carbamate
Isopropyl-N-(3-chlorphenyl)-carbamat (German)
Isopropyl-N-m-chlorophenyl-carbamate
Keim-stop
Liro CIPC
m-Chlorocarbanilic acid, isopropyl ester
Metoxon
Mirvale
N-(3-Chloor-fenyl)-isopropyl carbamaat (Dutch)
N-(3-Chloro phenyl) carbamate d'isopropyle (French)
N-(3-Chlorophenyl)carbamic acid, isopropyl ester
N-(3-Chlor-phenyl)-isopropyl-carbamat (German)
N-(3-Cloro-fenil)-isopropil-carbammato (Italian)
Nexoval
O-Isopropyl N-(3-chlorophenyl)carbamate
Preventol
Preventol 56
Sprout nip
Sprout-nip EC
Stopgerme-S
Taterpex
Triherbicide CIPC
Unicrop CIPC
Y 3

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformkidney/hamster2500 µg/LPMRSDJ 1,638,1981
mutation in mammalian somatic cellslymphocyte/mouse31500 µg/LPMRSDJ 1,580,1981
mutation in microorganisms/Saccharomyes cerevisiae100 mg/L (-enzymatic activation step)PMRSDJ 1,414,1981
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae25 mg/LPMRSDJ 1,468,1981
specific locus testother cell types/mouse147 µmol/LMUREAV 608,29,2006
Unscheduled DNA Synthesisfibroblast/human4 mg/LPMRSDJ 1,528,1981
Unscheduled DNA Synthesislymphocyte/human30 mg/LABILAE 92,367,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 3 gm/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 11,697,1997
subcutaneous/mouse 9 gm/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 600 mg/kgTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 12,355,1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 2600 mg/kgCRSBAW 175,496,1981
intraperitoneal/rat lethal dose (50 percent kill): 700 mg/kgCRSBAW 175,496,1981
oral/mouse lethal dose (50 percent kill): 3650 mg/kgFACOEB 16,173,1999
oral/rabbit lethal dose (50 percent kill): 5 gm/kgPAREAQ 14,225,1962
oral/rat lethal dose (50 percent kill): 1200 mg/kgEye: Other eye effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
AEHLAU 19,621,1969
unreported route/duck lethal dose (50 percent kill): >2 gm/kgFMCHA2 -,C73,1991
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 3 gm/kg30ZDA9 -,200,1971
unreported route/rat lethal dose (50 percent kill): 3350 mg/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 789 gm/kg/1Y- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 2,659,1960
oral/rat lowest published toxic dose: 126 gm/kg/2W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral/rat lowest published toxic dose: 252 gm/kg/4W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral/rat lowest published toxic dose: 378 gm/kg/6W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral/rat lowest published toxic dose: 504 gm/kg/8W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral/rat lowest published toxic dose: 819 gm/kg/13W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 39,353,2001
oral/rat lowest published toxic dose: 3276 mg/kg/13W- continuousBlood: Changes in spleenFCTOD7 42,1469,2004
oral/rat lowest published toxic dose: 16.4 gm/kg/13W- continuousEndocrine: Changes in spleen weight

Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above
FCTOD7 42,1469,2004
oral/rat lowest published toxic dose: 81.9 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FCTOD7 42,1469,2004
oral/rat lowest published toxic dose: 1092 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 2,659,1960
oral/rat lowest published toxic dose: 68250 mg/kg/13W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TXCYAC 123,111,1997

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,55,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,55,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 71,54953,2006
TOXICOLOGY REVIEWFEREAC 72,37646,2007
TOXICOLOGY REVIEWJTPAE7 19,1,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,99,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
On EPA IRIS database
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