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Carbamic acid, ethyl ester

RTECS #: FA8400000

CAS #: 51-79-6


UPDATE: May 2009 MW: 89.11 MF: C3H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. A 11032
  2. Aethylcarbamat (German)
  3. Aethylurethan (German)
  4. Carbamidsaeure - aethylester (German)
  5. Ethyl carbamate
  6. Ethyl urethane
  7. Ethylester kyseliny karbaminove (Czech)
  8. Ethylurethan
  9. Leucethane
  10. Leucothane
  11. NSC 746
  1. O - Ethylurethane
  2. Pracarbamin
  3. Pracarbamine
  4. RCRA waste number U238
  5. U - Compound
  6. Uretan
  7. Uretan etylowy (Polish)
  8. Urethan
  9. Urethane
  10. X 41


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay mouse
Escherichia coli
1,400 mg/kg/28 day EMMUEG 41,43,2003
cytogenetic analysis hamster lung 10 gm/L ATSUDG 4,41,1980
cytogenetic analysis hamster fibroblast 8 gm/L/48 hour MUREAV 48,337,1977
cytogenetic analysis subcutaneous
mouse
20 mg/kg JJCREP 76,1141,1985
cytogenetic analysis intraperitoneal
mouse
5 gm/kg/10 day- intermittent IJCNAW 4,327,1969
cytogenetic analysis skin
mouse
8 gm/kg MUREAV 271,223,1992
cytogenetic analysis inhalation
mouse
1,280 g/L/48 hour- continuous MUREAV 369,59,1996
cytogenetic analysis subcutaneous
mouse
0.3 mg/kg/7 day- intermittent TPKVAL 13,86,1973
cytogenetic analysis intravenous
rat
800 mg/kg JJIND8 67,831,1981
cytogenetic analysis intraperitoneal
rat
100 mg/kg MUREAV 371,259,1996
DNA adduct intraperitoneal
mouse
400 mg/kg CBINA8 6,99,1973
DNA damage Bacillus subtilis 2 mg/disc PMRSDJ 1,175,1981
DNA damage human fibroblast 3 mmol/L ENMUDM 7,267,1985
DNA damage parenteral
mouse
1 gm/kg IJCAAR 10,403,1973
DNA damage oral
mouse
1,400 mg/kg/28 day EMMUEG 41,43,2003
DNA damage rat liver 100 mmol/L SinJF# 26OCT1982
DNA inhibition human fibroblast 200 mmol/L MUREAV 183,89,1987
DNA inhibition intraperitoneal
mouse
500 mg/kg MUREAV 46,305,1977
DNA inhibition skin
mouse
13,600 mol/kg CNREA8 33,769,1973
DNA inhibition subcutaneous
mouse
1,200 mg/kg CBINA8 19,327,1977
DNA inhibition intraperitoneal
rat
1 gm/kg CNREA8 33,2149,1973
unscheduled DNA synthesis human HeLa cell 10 mol/L CNREA8 38,2621,1978
unscheduled DNA synthesis human fibroblast 20 mg/L TXCYAC 21,151,1981
unscheduled DNA synthesis intraperitoneal
mouse
750 mg/kg EMMUEG 24,68,1994
unscheduled DNA synthesis rat liver 100 mol/L CNREA8 42,3010,1982
unscheduled DNA synthesis rat other cell types 1 mole/L SHKKAN 22,300,1980
host-mediated assay mouse
Escherichia coli
670 mg/kg MUREAV 272,161,1992
mutation in microorganisms Escherichia coli 50 gm/L/1 hour (-enzymatic activation step) CRSUBM 3,69,1955
mutation in microorganisms Escherichia coli 50 g/plate (+enzymatic activation step) PMRSDJ 1,351,1981
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) APMBAY 6,45,1958
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) PMRSDJ 1,351,1981
mutation in microorganisms Salmonella typhimurium 500 mg/L/72 hour (-enzymatic activation step) MUREAV 558,181,2004
mutation in microorganisms Saccharomyes cerevisiae 71,200 mol/L (+enzymatic activation step) MUREAV 45,309,1977
mutation in microorganisms Saccharomyes cerevisiae 10,300 mg/L/16 hour MUTAEX 20,105,2004
mutation in microorganisms Saccharomyes cerevisiae 12,500 mg/L/18 hour (+enzymatic activation step) MUREAV 653,63,2008
micronucleus test hamster ovary 3,500 mg/L/24 hour MUREAV 607,61,2006
micronucleus test hamster fibroblast 800 mg/L/24 hour MUREAV 607,88,2006
micronucleus test hamster ovary 56,123 mol/L/24 hour (-enzymatic activation step) MUREAV 630,1,2007
micronucleus test intraperitoneal
mouse
30 mg/kg/2 day- intermittent PMRSDJ 1,705,1981
micronucleus test parenteral
mouse
40 mg/kg TUMOAB 69,387,1983
micronucleus test skin
mouse
2 mg/kg EMMUEG 17,163,1991
micronucleus test oral
mouse
300 mg/kg EMMUEG 41,43,2003
micronucleus test intraperitoneal
mouse
750 mg/kg MUTAEX 17,15,2002
micronucleus test unreported route
mouse
30 mg/kg/6 week- intermittent TOXID9 44,366,2005
micronucleus test intraperitoneal
rat
15 gm/kg/10 week- intermittent MUREAV 127,169,1984
micronucleus test oral
rat
600 mg/kg MUREAV 262,247,1991
micronucleus test intraperitoneal
rat
750 mg/kg MUTAEX 17,15,2002
gene conversion and mitotic recombination Saccharomyes cerevisiae 150 mg/L PMRSDJ 1,491,1981
mutation in mammalian somatic cells intraperitoneal
mouse
3,000 gm/L/1 week CALEDQ 153,199,2000
mutation in mammalian somatic cells intraperitoneal
mouse
1,000 mg/kg TOXID9 90,384,2006
morphological transform intraperitoneal
hamster
1 gm/kg ARPAAQ 95,380,1973
morphological transform hamster kidney 80 g/L BJCAAI 37,873,1978
morphological transform mouse embryo 1,100 mol/L MUREAV 152,113,1985
morphological transform mouse fibroblast 500 g/L CRNGDP 3,1235,1982
morphological transform mouse fibroblast 0.5 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform intraperitoneal
rat
800 mg/kg CNREA8 40,1157,1980
morphological transform oral
rat
5,040 mg/kg/6 week CRNGDP 9,387,1988
other mutation test systems parenteral
mouse
750 mg/kg ZKKOBW 76,69,1971
other mutation test systems intraperitoneal
mouse
741 mg/kg CBINA8 4,329,1971/1972
other mutation test systems intraperitoneal
rat
100 mg/kg MUREAV 371,259,1996
phage inhibition capacity Escherichia coli 100 mmol/L MDMIAZ 31,11,1979
sister chromatid exchange unreported route
hamster
400 mg/kg BANRDU 13,293,1982
sister chromatid exchange hamster fibroblast 10 mmol/L JNCIAM 58,1635,1977
sister chromatid exchange intraperitoneal
hamster
400 mg/kg MUREAV 126,159,1984
sister chromatid exchange human lymphocyte 10 mmol/L MUREAV 89,75,1981
sister chromatid exchange intraperitoneal
mouse
3,300 mol/kg CRNGDP 5,399,1984
sister chromatid exchange inhalation
mouse
220 g/L MUREAV 88,223,1981
sister chromatid exchange intravenous
mouse
1,100 mol/kg TCMUD8 10,1,1990
sister chromatid exchange unreported route
mouse
400 mg/kg BANRDU 13,293,1982
sister chromatid exchange intraperitoneal
rat
400 mg/kg MUREAV 126,159,1984
sister chromatid exchange unreported route
rat
400 mg/kg BANRDU 13,293,1982
sister chromatid exchange rat liver 5 mmol/L MUREAV 93,409,1982
sex chromosome loss and nondisjunction Aspergillus nidulans 169 mmol/L MUREAV 172,139,1986
sex chromosome loss and nondisjunction multiple
Drosophila melanogaster
40 mmol/L CRNGDP 17,1083,1996
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
55,000 ppm/6 hour CNREA8 39,4224,1979
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
100 mmol/L/3 day- intermittent CRNGDP 5,571,1984
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
56,200 mol/L CNREA8 30,195,1970
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 150 mg/L PMRSDJ 1,468,1981
specific locus test oral
Drosophila melanogaster
500 mol/L CNJGA8 17,55,1975
specific locus test multiple
Drosophila melanogaster
10 mmol/L CRNGDP 17,1083,1996
specific locus test Drosophila melanogaster 5 mmol/L/7 day MUREAV 513,61,2002
specific locus test oral
Drosophila melanogaster
0.5 pph/48 hour- continuous EMMUEG 45,90,2005
specific locus test multiple
Drosophila melanogaster
891 mg/L/48 hour EMMUEG 45,56,2005
specific locus test intraperitoneal
hamster
44.56 mg/kg MUREAV 657,160,2008
specific locus test subcutaneous
mouse
1 gm/kg CNREA8 43,1342,1983
sperm morphology inhalation
Drosophila melanogaster
55,000 ppm/6 hour CNREA8 39,4224,1979
sperm morphology intraperitoneal
mouse
25 gm/kg/5 day- intermittent CMMUAO 5,257,1978
heritable translocation test oral
Drosophila melanogaster
11 ppb EMMUEG 23,51,1994
heritable translocation test oral
Drosophila melanogaster
10 mmol/L/48 hour FCTOD7 41,41,2003
heritable translocation test multiple
Drosophila melanogaster
0.5 mole/L/48 hour EMMUEG 45,90,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 499 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Skin and skin appendages
CNREA8 27,1696,1967
intraperitoneal
hamster
lowest published toxic dose: 499 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CNREA8 27,1696,1967
intraperitoneal
hamster
lowest published toxic dose: 400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
ARPAAQ 81,174,1966
intraperitoneal
mouse
lowest published toxic dose: 1,500 mg/kg (1 day male) Reproductive: Other reproductive system tumors TXAPA9 158,161,1999
intraperitoneal
mouse
lowest published toxic dose: 3,750 mg/kg (5 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders JRPFA4 51,159,1977
intraperitoneal
mouse
lowest published toxic dose: 3 gm/kg (6 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility
JRPFA4 51,159,1977
intraperitoneal
mouse
lowest published toxic dose: 1,200 mg/kg (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
POASAD 56,10,1976
intraperitoneal
mouse
lowest published toxic dose: 1 gm/kg (18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 24,251,1982
intraperitoneal
mouse
lowest published toxic dose: 1,200 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
KAIZAN 43,378,1968
intraperitoneal
mouse
lowest published toxic dose: 1,250 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Hepatobiliary system
IJEBA6 8,167,1970
intraperitoneal
mouse
lowest published toxic dose: 1,250 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Respiratory system IJEBA6 8,167,1970
intraperitoneal
rat
lowest published toxic dose: 1,200 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ENDOAO 90,1594,1972
intraperitoneal
rat
lowest published toxic dose: 10 gm/kg (20 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) HIKYAJ 12,1339,1966
intrauterine
mouse
lowest published toxic dose: 10,000 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system HBPTO* 1,776,2001
intravenous
dog
lowest published toxic dose: 1 gm/kg (20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JZKEDZ 6,37,1980
intravenous
hamster
lowest published toxic dose: 400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ARPAAQ 81,174,1966
intravenous
hamster
lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
ARPAAQ 81,174,1966
intravenous
mouse
lowest published toxic dose: 490 mg/kg (13-17 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) EMMUEG 14,90,1989
intravenous
rat
lowest published toxic dose: 1,300 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ENDOAO 91,87,1972
oral
mouse
lowest published toxic dose: 1,600 mg/kg (4-7 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) APTOA6 8,82,1952
oral
mouse
lowest published toxic dose: 4 gm/kg (8-12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 6,361,1986
oral
rat
lowest published toxic dose: 7 gm/kg (6-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JJPAAZ 16,63,1966
oral
rat
lowest published toxic dose: 2 gm/kg (8-9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JJPAAZ 16,63,1966
oral
rat
lowest published toxic dose: 2 gm/kg (6-7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JJPAAZ 16,63,1966
subcutaneous
mouse
lowest published toxic dose: 1 gm/kg (15 day pregnant) Reproductive: Effects on newborn: Stillbirth GANNA2 63,731,1972
subcutaneous
mouse
lowest published toxic dose: 45 mg/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 550 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
JOIMD6 8,243,1986
subcutaneous
mouse
lowest published toxic dose: 418 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 30 mg/kg (1-18 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
TPKVAL 15,36,1979
subcutaneous
mouse
lowest published toxic dose: 3,060 mg/kg (1-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TPKVAL 15,36,1979
subcutaneous
mouse
lowest published toxic dose: 306 mg/kg (1-18 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system
TPKVAL 15,36,1979
subcutaneous
mouse
lowest published toxic dose: 306 mg/kg (1-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TPKVAL 15,36,1979
subcutaneous
rat
lowest published toxic dose: 1,200 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ENDOAO 90,1594,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2,500 mg/m3/10 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JJCREP 81,742,1990
inhalation
mouse
lowest published toxic concentration: 138 ppm/130 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AEHLAU 22,663,1971
intraperitoneal
mouse
lowest published toxic dose: 2,500 mg/kg (7-11 day pregnant) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Tumorigenic effects: Ovarian tumors
IARCCD 4,14,1973
intraperitoneal
mouse
lowest published toxic dose: 500 mg/kg (19 day pregnant) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
CNREA8 38,137,1978
intraperitoneal
mouse
lowest published toxic dose: 7 mg/kg/39 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
SCIEAS 147,1443,1965
intraperitoneal
mouse
toxic dose : 880 mg/kg/7 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Ear: Tumors

Liver: Tumors
CNREA8 40,1194,1980
intraperitoneal
mouse
toxic dose : 4,990 g/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 43,1124,1983
intraperitoneal
mouse
toxic dose : 800 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 36,1744,1976
intraperitoneal
mouse
toxic dose : 10 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 33,3069,1973
intraperitoneal
mouse
toxic dose : 400 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 35,1411,1975
intraperitoneal
mouse
toxic dose : 500 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 44,107,1984
intraperitoneal
mouse
toxic dose : 1,000 mg/kg (18 day pregnant) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
JNCIAM 8,63,1947
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 145,101,1999
intraperitoneal
mouse
lowest published toxic dose: 125 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 145,101,1999
intraperitoneal
mouse
lowest published toxic dose: 1,500 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VHTODE 42,129,2000
intraperitoneal
mouse
lowest published toxic dose: 1,000 mg/kg/15 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens

Lung, Thorax, or Respiration: Tumors
VOONC* -,704,1992
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JTSCDR 26,129,2001
intraperitoneal
mouse
lowest published toxic dose: 1,000 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TOLED5 142,111,2003
intraperitoneal
mouse
lowest published toxic dose: 5,000 mg/kg/15 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 217,129,2006
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JTPAE7 15,215,2002
intraperitoneal
mouse
lowest published toxic dose: 400 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CNREA8 67,9248,2007
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg (19 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors
CNREA8 30,2552,1970
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
RRCRBU 52,29,1975
intravenous
mouse
lowest published toxic dose: 1,000 mg/kg (18 day pregnant) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
JNCIAM 8,63,1947
intravenous
mouse
lowest published toxic dose: 1 gm/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
CNREA8 22,299,1962
oral
hamster
lowest published toxic dose: 55 gm/kg/64 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
EJCAAH 5,165,1969
oral
monkey
lowest published toxic dose: 325 gm/kg/5 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
PAACA3 21,78,1980
oral
mouse
lowest published toxic dose: 12 gm/kg/15 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
TUMOAB 53,81,1967
oral
mouse
toxic dose : 1,200 mg/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
BJCAAI 15,322,1961
oral
mouse
toxic dose : 1,280 mg/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
BJCAAI 15,322,1961
oral
mouse
lowest published toxic dose: 18 gm/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Neoplastic by RTECS criteria

Vascular: Tumors
EVHPAZ 108,61,2000
oral
mouse
lowest published toxic dose: 22.68 gm/kg/27 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
JTPAE7 16,85,2003
oral
rat
lowest published toxic dose: 30 gm/kg/52 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 7,107,1947
subcutaneous
hamster
lowest published toxic dose: 1 gm/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
IJCNAW 6,63,1970
subcutaneous
mouse
lowest published toxic dose: 1 gm/kg (11 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
CALEDQ 18,131,1983
subcutaneous
mouse
lowest published toxic dose: 1,000 mg/kg (15 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
CNREA8 30,2552,1970
subcutaneous
mouse
lowest published toxic dose: 200 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors
CNREA8 34,2217,1974
subcutaneous
mouse
toxic dose : 500 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Tumor types after systemic administration not seen spontaneously
CNREA8 33,1677,1973
subcutaneous
mouse
lowest published toxic dose: 1.5 gm/kg/14 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
EJCAAH 40,275,2004
subcutaneous
rat
lowest published toxic dose: 8 gm/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Eye: Tumors
JNCIAM 43,749,1969
skin
hamster
lowest published toxic dose: 1,000 mg/kg/1 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
CRSBAW 158,440,1964
skin
mouse
lowest published toxic dose: 90 gm/kg/56 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
CRNGDP 5,911,1984
unreported route
mouse
lowest published toxic dose: 1 gm/kg (17 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
BCSTB5 2,710,1974
unreported route
mouse
lowest published toxic dose: 1,000 mg/kg (17 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors
BCSTB5 2,710,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraarterial
guinea pig
lowest published lethal dose: 800 mg/kg N/R AEPPAE 131,171,1928
intramuscular
rat
lethal dose (50 percent kill): 1,400 mg/kg N/R ZKKOBW 84,227,1975
intraperitoneal
mouse
lethal dose (50 percent kill): 1,539 mg/kg N/R PMRSDJ 1,682,1981
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Behavioral: Food intake (animal) JTSCDR 26,129,2001
intraperitoneal
mouse
lowest published lethal dose: 250 mg/kg N/R JTSCDR 26,129,2001
intraperitoneal
rat
lethal dose (50 percent kill): 1,500 mg/kg N/R CNREA8 26,1448,1966
intraperitoneal
rat
lowest published toxic dose: 1,300 mg/kg Brain and Coverings: Other degenerative changes

Endocrine: Hyperglycemia

Endocrine: Other changes
AJBSAM 40,91,1987
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg Behavioral: Sleep ENDOAO 106,343,1980
intravenous
guinea pig
lowest published lethal dose: 800 mg/kg N/R AEPPAE 131,171,1928
intravenous
mouse
lethal dose (50 percent kill): 500 mg/kg N/R APJUA8 5,43,1955
intravenous
rabbit
lowest published lethal dose: 2 gm/kg N/R 27ZIAQ -,272,1973
multiple
rat
lowest published toxic dose: 1.5 gm/kg Endocrine: Hyperglycemia CYLPDN 21,271,2000
oral
chicken
lowest published lethal dose: 2,188 mg/kg N/R FDWU** -,-,1931
oral
mouse
lethal dose (50 percent kill): 2,500 mg/kg N/R ARZNAD 9,595,1959
oral
mouse
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Other changes

Blood: Other changes
TOXID9 72,318,2003
oral
mouse
lethal dose (16 percent kill): 1,900 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Behavioral: Ataxia
TPKVAL 13,86,1973
oral
mouse
lethal dose : 3,500 mg/kg N/R TPKVAL 13,86,1973
oral
pigeon
lowest published lethal dose: 800 mg/kg N/R FDWU** -,-,1931
oral
rat
lethal dose (50 percent kill): 1,809 mg/kg N/R CALEDQ 57,37,1991
parenteral
mouse
lowest published lethal dose: 1 gm/kg Gastrointestinal: Peritonitis NCISA* PH-43-62-483
subcutaneous
mouse
lethal dose (50 percent kill): 1,750 mg/kg N/R GANNA2 63,731,1972
subcutaneous
rat
lowest published lethal dose: 1,800 mg/kg N/R AEPPAE 182,348,1936
unreported route
mouse
lethal dose (50 percent kill): 2 gm/kg N/R BJCAAI 6,160,1952
unreported route
rat
lowest published toxic dose: 800 mg/kg Behavioral: General anesthetic FATOAO 49,107,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 700 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TOXID9 54,161,2000
intraperitoneal
mouse
lowest published toxic dose: 5,000 mg/kg/2 day- intermittent Lung, Thorax, or Respiration: Tumors TOXID9 44,366,2005
oral
mouse
lowest published toxic dose: 20 gm/kg/13 week- continuous Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
NTPTR* NIH-96-3937
oral
mouse
lowest published toxic dose: 1,800 mg/kg/180 day- intermittent Vascular: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 108,61,2000
oral
mouse
lowest published toxic dose: 18 gm/kg/180 day- intermittent Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Increased incidence of tumors in susceptible strains

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 108,61,2000
oral
mouse
lowest published toxic dose: 18 gm/kg/180 day- intermittent Lung, Thorax, or Respiration: Tumors

Liver: Tumors

Endocrine: Changes in thymus weight
EVHPAZ 108,61,2000
oral
mouse
lowest published toxic dose: 500 mg/kg/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes
TOXID9 72,318,2003
oral
mouse
lowest published toxic dose: 36,400 mg/kg/26 week- continuous Liver: Tumors TOXID9 60,203,2001
oral
mouse
lowest published toxic dose: 123.2 mg/kg/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 89.6 mg/kg/4 week- intermittent Lung, Thorax, or Respiration: Other changes NTPTR* TR-510
oral
mouse
lowest published toxic dose: 1,040,000 g/kg/80 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-510
oral
mouse
lowest published toxic dose: 10,512,000 g/kg/2 year- intermittent Behavioral: Fluid intake

Lung, Thorax, or Respiration: Tumors

Liver: Angiosarcoma
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 10,512,000 g/kg/2 year- intermittent Cardiac: Other changes

Cardiac: Tumors

Gastrointestinal: Tumors
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 9,490,000 g/kg/2 year- intermittent Lung, Thorax, or Respiration: Tumors

Liver: Angiosarcoma

Skin and Appendages: Tumors
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 9,490,000 g/kg/2 year- intermittent Cardiac: Other changes

Reproductive: Tumorigenic effects: Ovarian tumors

Reproductive: Tumorigenic effects: Uterine tumors
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 9,490,000 g/kg/2 year- intermittent Skin and Appendages: Tumors NTPTR* TR-510
oral
mouse
lowest published toxic dose: 3,358,000 g/kg/2 year- intermittent Liver: Other changes

Liver: Tumors

Skin and Appendages: Tumors
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 1,022,000 g/kg/2 year- intermittent Eye: Tumors

Liver: Other changes

Liver: Tumors
NTPTR* TR-510
oral
mouse
lowest published toxic dose: 1,168,000 g/kg/2 year- intermittent Eye: Tumors NTPTR* TR-510
oral
mouse
lowest published toxic dose: 3,066,000 g/kg/2 year- intermittent Blood: Tumors

Reproductive: Maternal effects: Uterus, cervix, vagina
NTPTR* TR-510
oral
rat
lowest published toxic dose: 7,098 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count
NTPTR* NIH-96-3937
subcutaneous
mouse
lowest published toxic dose: 3,000 mg/kg/3 day- intermittent Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CRNGDP 25,1973,2004
unreported route
mouse
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
HBPTO* 1,776,2001
unreported route
mouse
lowest published toxic dose: 1 mg/kg/10 day- intermittent Immunological Including Allergic: Decrease in cellular immune response HBPTO* 1,776,2001
unreported route
mouse
lowest published toxic dose: 30 mg/kg/6 week- intermittent Lung, Thorax, or Respiration: Tumors

Liver: Tumors
TOXID9 44,366,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 7,111,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 7,111,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
FEPRA7 35,89,1976
TOXICOLOGY REVIEW
JAMAAP 172,1765,1960
TOXICOLOGY REVIEW
32XPAD -,49,1975
TOXICOLOGY REVIEW
CLPTAT 5,480,1964
TOXICOLOGY REVIEW
ADVPA3 4,263,1966
TOXICOLOGY REVIEW
CNREA8 35,2895,1975
TOXICOLOGY REVIEW
ONCOBS 33,66,1976
TOXICOLOGY REVIEW
BLFSBY 24,129,1983
TOXICOLOGY REVIEW
TIHEEC 5,1045,1989
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUTAEX 14,141,1999
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
ENTOX* -,411,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 33,63,2005
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
ITODC* -,327,2004
TOXICOLOGY REVIEW
MUREAV 544,425,2003
TOXICOLOGY REVIEW
MUREAV 608,136,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3213;
Number of Industries 8;
Total Number of Facilities 1,299;
Number of Occupations 8;
Total Number of Employees Exposed 9,459;
Total Number of Female Employees Exposed 5,050


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in manufacture of pharmaceuticals, pesticides and fungicides
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Toxicity studies, RPT# TOX-52, October 2000
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE

27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ.
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJBSAM Australian Journal of Biological Sciences. (Commonwealth Scientific and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic. 3002, Australia) V.6- 1953-
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb, Yugoslavia) V.1-41, 1951-91. For publisher information, see ACPHEE
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.1- 1979-
BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CRSUBM Cancer Research Supplement. (Baltimore, MD) No.1-4, 1953-56.
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HIKYAJ Hinyokika Kiyo. Journal of Urology. (Kyoto Daigaku Igakubu, Hinyokikagaku Kyoshitsu, 54 Kawara-machi, Shogain, Sakyo-ku, Kyoto 606, Japan) V.1- 1955-
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IJCAAR Indian Journal of Cancer. (Indian Cancer Soc., Parel, Bombay, 400 012, India) V.1- 1963-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITODC*
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOIMD6 Journal of Immunopharmacology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1978/79-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975-
KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928-
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCISA* Progress Report for Contract No. PH-43-63-1132, Submitted to the National Cancer Institute by Scientific Associates, Inc. (6200 S. Lindberg Blvd., St. Louis, MO 63123)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920-
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SHKKAN Shika Kiso Igakkai Zasshi. Journal of the Japanese Association for Basic Dentistry. (Shika Kiso Igakkai, Hanayama Bldg., 1-44-2 Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1959-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.

Used as an intermediate in manufacture of pharmaceuticals, pesticides and fungicides

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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