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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbamic acid, diisopropylthio-, S-(2,3,3-trichloroallyl) ester

RTECS #

EZ8575000

CAS #

2303-17-5

Updated

January 2010

Molecular Weight

304.68

Molecular Formula

C10H16Cl3NOS

Synonyms

2,3,3-Trichlorallyl-N,N-(diisopropyl)-thiocarbamat (German)
2,3,3-Trichloroallyl diisopropylthiocarbamate
2-Propene-1-thiol, 2,3,3-trichloro-, diisopropylcarbamate
Avadex BW
CP 23426
Diisopropyltrichloroallylthiocarbamate
Dipthal
Far-Go
N,N-Diisopropyl-2,3,3-trichlorallyl-thiolcarbamat (German)
N-Diisopropylthiocarbamic acid S-2,3,3-trichloro-2-propenyl ester
S-2,3,3-Trichloroallyl diisopropylthiocarbamate
S-2,3,3-Trichloroallyl N,N-diisopropylthiocarbamate
Thiocarbamic acid, N-diisopropyl-, S-2,3,3-trichloroallyl ester
Triallat (German)
Triallate
Triamyl

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster100 µmol/LMUREAV 85,45,1981
DNA inhibitionlymphocyte/human100 mg/LARTODN 45,101,1980
DNA inhibitionother cell types/rat100 mg/LARTODN 45,101,1980
gene conversion and mitotic recombination/Saccharomyes cerevisiae40 ppmNTIS** PB84-138973
mutation in mammalian somatic cellslymphocyte/mouse10 mg/LNTIS** PB84-138973
mutation in microorganisms/Salmonella typhimurium4800 µg/plate (+enzymatic activation step)MUREAV 57,277,1978
mutation in microorganisms/Salmonella typhimurium100 nmol/plate (-enzymatic activation step)BCPCA6 32,3739,1983
mutation in microorganisms/Escherichia coli5 mg/L (-enzymatic activation step)GNKAA5 22,2416,1986
mutation in microorganisms/Bacillus subtilis100 µg/plate (+enzymatic activation step)JAFCAU 29,268,1981
mutation in microorganisms/Other microorganisms4800 µg/plate (-enzymatic activation step)CBINA8 22,297,1978
sister chromatid exchangeovary/hamster20 µmol/LMUREAV 85,45,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
unreported route/mammal (species unspecified) 30 mg/kg (multigenerations)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
FEREAC 65,58376,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 400 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)
GISAAA 33(7),37,1968
oral/mouse lethal dose (50 percent kill): 930 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GISAAA 33(7),37,1968
oral/quail lethal dose (50 percent kill): 2251 mg/kgPEMNDP 9,835,1991
oral/rat lethal dose (50 percent kill): 800 mg/kg85JFAN A403,1984
skin/rabbit lethal dose (50 percent kill): 2225 mg/kg28ZEAL 5,226,1976
skin/rat lowest published lethal dose: 3500 mg/kgGISAAA 33(7),37,1968
unreported route/Dog Lethal dose: >20 gm/kg85JFAN A403,1984
unreported route/mouse lethal dose (50 percent kill): 832 mg/kgTGANAK 16(1),45,1982
unreported route/rat lethal dose (50 percent kill): 1471 mg/kgEQSSDX 3,618,1975
unreported route/rat lowest published toxic dose: 300 mg/kgBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 65,58377,2000

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 40 mg/m3/4H/17W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)GISAAA 33(7),37,1968
oral/rat lowest published toxic dose: 17493 mg/kg/17W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldGISAAA 33(7),37,1968

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWFEREAC 71,56425,2006
TOXICOLOGY REVIEWFEREAC 72,28881,2007
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFEREAC 74,29958,2009
TOXICOLOGY REVIEWFEREAC 73,53732,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,214,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
On EPA IRIS database
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