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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbamic acid, diethyldithio-, sodium salt

RTECS #

EZ6475000

CAS #

148-18-5

Updated

July 2013

Molecular Weight

171.27

Molecular Formula

C5H10NS2·Na

Synonyms

Carbamodithioic acid, diethyl-, sodium salt (9CI)
Cupral
DEDC
Diethylcarbamodithioic acid, sodium salt
Diethyldithiocarbamate sodium
Diethyldithiocarbamic acid, sodium salt
Dithiocarb
Imuthiol
Kupral
NCI CO2835
Sodium DEDT
Sodium diethylcarbamodithioate
Sodium diethyldithiocarbamate
Sodium N,N-diethyldithiocarbamate
Sodium salt of N,N-diethyldithiocarbamic acid
Soxinol ESL
Thiocarb
USAF EK-2596

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat5200 mg/kgMUREAV 53,212,1978
DNA DamageHeLa cell/human100 µmol/LBBACAQ 519,65,1978
DNA Damagelymphocyte/mouse1500 µmol/LMUREAV 203,155,1988
DNA Damageliver/human0.316 mmol/l/48HMUREAV 696,21,2010
DNA inhibitionother cell types/rat1 mg/LCBINA8 64,151,1987
DNA inhibitionintraperitoneal/rat500 mg/kgCBINA8 64,151,1987
other mutation test systems/Other microorganisms100 µmol/LBBACAQ 519,65,1978
specific locus testinhalation/mouse0.39 µmol/LMUREAV 608,29,2006
specific locus testlymphocyte/mouse31 µg/LEMMUEG 17,196,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 2100 mg/kg (7D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Endocrine: Androgenic
ANDRDQ 17,400,1985
intraperitoneal/Dog 100 mg/kg (1D male)Reproductive: Other effects on maleNYKZAU 75,425,1979
intraperitoneal/Dog 50 mg/kg (1D male)Reproductive: Other effects on maleANDRDQ 12,85,1980
subcutaneous/mouse 1935 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB223-160
subcutaneous/mouse 1935 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 76 gm/kg/78W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1032 mg/kgPHTOEH 64,247,1989
intraperitoneal/rat lethal dose (50 percent kill): 1250 mg/kgPHARAT 27,139,1972
oral/mouse lethal dose (50 percent kill): 1500 mg/kgDRFUD4 6,225,1981
oral/rabbit lethal dose (50 percent kill): 500 mg/kgFATOAO 32,356,1969
oral/rat lethal dose (50 percent kill): 1500 mg/kgDRFUD4 6,225,1981
skin/rat lethal dose (50 percent kill): >1 gm/kgWRPCA2 9,119,1970
subcutaneous/rat lowest published toxic dose: 800 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 208,367,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 3357 mg/kg/8W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheathNRTXDN 28,645,2007
intraperitoneal/rat lowest published toxic dose: 4.2 mg/kg/2W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheathTXAPA9 229,77,2008
oral/chicken lowest published toxic dose: 9900 mg/kg/30D- intermittentBehavioral: AtaxiaPCBPBS 19,243,1983
oral/mouse lowest published toxic dose: 7 gm/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
JTEHD6 37,559,1992
subcutaneous/mouse lowest published toxic dose: 100 mg/kg/4D- intermittentImmunological Including Allergic: Increase in humoral response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Tumorigenic: Active as anti-cancer agent
FATOAO 55,46,1992

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,217,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,217,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWCTOXAO 12,601,1978
TOXICOLOGY REVIEWEMMUEG 43,36,2004
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 672,17,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 mg/m3;KZW 8 mg/m3, inhal, sen, 2007
Occupational Exposure Limit-GERMANYMAK 0.05 mg/m3, inhal, skin sen, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg/m3, KZG-week 4 mg/m3, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84765; Number of Industries 17; Total Number of Facilities 445; Number of Occupations 16; Total Number of Employees Exposed 7970; Total Number of Female Employees Exposed 1982
National Occupational Hazard Survey 1974Hazard Code 84765; Number of Industries 2; Total Number of Facilities 86; Number of Occupations 2; Total Number of Employees Exposed 732

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-172,1979
On EPA IRIS database
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