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Carbamic acid, diethyldithio - , sodium salt

RTECS #: EZ6475000

CAS #: 148-18-5


UPDATE: May 2009 MW: 171.27 MF: C5H10NS2ĽNa


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Carbamodithioic acid, diethyl - , sodium salt (9CI)
  2. Cupral
  3. DEDC
  4. Diethylcarbamodithioic acid, sodium salt
  5. Diethyldithiocarbamate sodium
  6. Diethyldithiocarbamic acid, sodium salt
  7. Dithiocarb
  8. Imuthiol
  9. Kupral
  1. NCI CO2835
  2. Sodium DEDT
  3. Sodium diethylcarbamodithioate
  4. Sodium diethyldithiocarbamate
  5. Sodium N,N - diethyldithiocarbamate
  6. Sodium salt of N,N - diethyldithiocarbamic acid
  7. Soxinol ESL
  8. Thiocarb
  9. USAF EK - 2596


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
5,200 mg/kg MUREAV 53,212,1978
DNA damage human HeLa cell 100 Ámol/L BBACAQ 519,65,1978
DNA damage mouse lymphocyte 1,500 Ámol/L MUREAV 203,155,1988
DNA inhibition rat other cell types 1 mg/L CBINA8 64,151,1987
DNA inhibition intraperitoneal
rat
500 mg/kg CBINA8 64,151,1987
other mutation test systems other microorganisms 100 Ámol/L BBACAQ 519,65,1978
specific locus test mouse lymphocyte 31 Ág/L EMMUEG 17,196,1991
specific locus test inhalation
mouse
0.39 Ámol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
dog
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Other effects on male NYKZAU 75,425,1979
intraperitoneal
dog
lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Other effects on male ANDRDQ 12,85,1980
intraperitoneal
rat
lowest published toxic dose: 2,100 mg/kg (7 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Endocrine: Androgenic
ANDRDQ 17,400,1985
subcutaneous
mouse
lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 76 gm/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 1,032 mg/kg N/R PHTOEH 64,247,1989
intraperitoneal
rat
lethal dose (50 percent kill): 1,250 mg/kg N/R PHARAT 27,139,1972
oral
mouse
lethal dose (50 percent kill): 1,500 mg/kg N/R DRFUD4 6,225,1981
oral
rat
lethal dose (50 percent kill): 1,500 mg/kg N/R DRFUD4 6,225,1981
oral
rabbit
lethal dose (50 percent kill): 500 mg/kg N/R FATOAO 32,356,1969
subcutaneous
rat
lowest published toxic dose: 800 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 208,367,2005
skin
rat
lethal dose (50 percent kill): >1 gm/kg N/R WRPCA2 9,119,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 3,357 mg/kg/8 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath NRTXDN 28,645,2007
intraperitoneal
rat
lowest published toxic dose: 4.2 mg/kg/2 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath TXAPA9 229,77,2008
oral
chicken
lowest published toxic dose: 9,900 mg/kg/30 day- intermittent Behavioral: Ataxia PCBPBS 19,243,1983
oral
mouse
lowest published toxic dose: 7 gm/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
JTEHD6 37,559,1992
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg/4 day- intermittent Immunological Including Allergic: Increase in humoral response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Tumorigenic: Active as anti-cancer agent
FATOAO 55,46,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,217,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,217,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
CTOXAO 12,601,1978
TOXICOLOGY REVIEW
EMMUEG 43,36,2004
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 672,17,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - GERMANY MAK 2 mg/m3 (skin, sen), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg/m3,KZG- week 4 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84765;
Number of Industries 2;
Total Number of Facilities 86;
Number of Occupations 2;
Total Number of Employees Exposed 732
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84765;
Number of Industries 17;
Total Number of Facilities 445;
Number of Occupations 16;
Total Number of Employees Exposed 7,970;
Total Number of Female Employees Exposed 1,982


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a latex accelerator in the rubber-processing industry
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-172,1979


REFERENCES:

CODEN
REFERENCE

ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a latex accelerator in the rubber-processing industry

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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