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Registry of Toxic Effects of Chemical Substances (RTECS)

Camphene

RTECS #

EX1055000

CAS #

79-92-5

Updated

July 2013

Molecular Weight

136.26

Molecular Formula

C10H16

Synonyms

3,3-Dimethyl-2-methylenenorcamphene
Bicyclo(2.2.1)heptane, 2,2-dimethyl-3-methylene- (9CI)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat2500 mg/kgNUCADQ 1,10,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 17100 mg/m3/4HBehavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
VCVPS* -,298,1998
inhalation/rat lethal concentration (50 percent kill): 17100 mg/m3/5MBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Behavioral: Alteration of classical conditioning
VCVPS* -,298,1998
inhalation/rat lethal concentration (50 percent kill): 17100 mg/m3/1HPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Behavioral: Irritability
VCVPS* -,298,1998
intraperitoneal/mouse Lethal dose: >500 mg/kgCBCCT* 4,376,1952
oral/rat lethal dose (50 percent kill): >5000 mg/kgHPV143 -,-,2002
skin/rabbit lethal dose (50 percent kill): >2500 mg/kgHPV143 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 3.6 mg/m3/24H/90D- continuousBehavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes
VCVPS* -,298,1998
inhalation/mammal (species unspecified) lowest published toxic concentration: 32.2 mg/m3/24H/90D- continuousLiver: Fatty liver degeneration

Liver: Other changes

Blood: Hemorrhage
VCVPS* -,298,1998
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HPV143 -,-,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 49,2471,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M4188; Number of Industries 81; Total Number of Facilities 6181; Number of Occupations 83; Total Number of Employees Exposed 114605; Total Number of Female Employees Exposed 29452
National Occupational Hazard Survey 1974Hazard Code M4188; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 4; Total Number of Employees Exposed 2675

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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