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Registry of Toxic Effects of Chemical Substances (RTECS)

Calcium gluconate

RTECS #

EW2100000

CAS #

299-28-5; 18016-24-5

Updated

March 2011

Molecular Weight

430.42

Molecular Formula

C12H22O14·Ca

Synonyms

Calcicol
Calciofon
Calcipur
Calcium D-gluconate
Calcium hexagluconate
Calglucol
Calglucon
D-Gluconic acid, calcium salt (2:1) (9CI)
Dragocal
Ebucin
Glucal
Glucobiogen
Gluconate de calcium (French)
Gluconato di calcio (Italian)
Kalpren
Novocal

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/infant lowest published toxic dose: 143 mg/kgSkin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Body temperature increase
JAMAAP 129,347,1945
intramuscular/infant lowest published lethal dose: 10 gm/kgBrain and Coverings: Meningeal changes

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Nutritional and Gross Metabolic: Body temperature increase
JAMAAP 129,347,1945
intraperitoneal/mouse lethal dose (50 percent kill): 2200 mg/kgJDGRAX 15(1-2),121,1984
intravenous/Dog lowest published lethal dose: 1987 mg/kgJPETAB 47,183,1933
intravenous/guinea pig lowest published lethal dose: 1810 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
AIPTAK 191,44,1971
intravenous/mouse lethal dose (50 percent kill): 950 mg/kgTXAPA9 4,492,1962
intravenous/rat lethal dose (50 percent kill): 950 mg/kgNIIRDN 6,226,1982
oral/mouse lowest published lethal dose: 10 gm/kgFRPPAO 26,144,1971
oral/rat lowest published lethal dose: 10 gm/kgFRPPAO 26,144,1971
oral/rat lowest published toxic dose: 5 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationINJPD2 38,397,2006
subcutaneous/mouse lethal dose (50 percent kill): 2890 mg/kgJAPMA8 45,47,1956

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 3 gm/kg/3D- intermittentBehavioral: Change in motor activity (specific assay)BJMRDK 35,451,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCLPH* 23(Suppl 1),40,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80373; Number of Industries 3; Total Number of Facilities 565; Number of Occupations 16; Total Number of Employees Exposed 29060; Total Number of Female Employees Exposed 23111
National Occupational Hazard Survey 1974Hazard Code 80373; Number of Industries 3; Total Number of Facilities 267; Number of Occupations 11; Total Number of Employees Exposed 14905

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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