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Calcium fluoride

RTECS #: EW1760000

CAS #: 7789-75-5


UPDATE: May 2009 MW: 78.08 MF: CaF2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acid - spar
  2. Calcium difluoride
  3. Fluorspar
  1. Irtran 3
  2. Liparite
  3. Met - spar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis rat Ascites tumor 1 gm/kg GANNA2 54,155,1963


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 3,200 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) DZZEA7 34,124,1979
intraperitoneal
mouse
lowest published toxic dose: 67,200 mg/kg (1-21 day pregnant) Reproductive: Other developmental abnormalities DZZEA7 34,484,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mammal (species unspecified)
lethal dose : >10 gm/kg N/R MTPEEI (7),32,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 2,638 mg/kg N/R DZZEA7 34,484,1979
intraperitoneal
rat
lethal dose (50 percent kill): >1,500 mg/kg N/R XEURAQ UR-154,1951
oral
guinea pig
lowest published lethal dose: >5 gm/kg N/R MEIEDD 11,253,1989
oral
rat
lethal dose (50 percent kill): 4,250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VAMNAQ (2),28,1977
oral
rat
lethal dose (50 percent kill): 4,417 mg/kg N/R VCVN5* -,354,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 44 gm/kg/31 day- intermittent Cardiac: EKG changes not diagnostic of above

Musculoskeletal: Changes in teeth and supporting structures

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
MTPEEI (7),32,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2.5 mg(F)/m3 DTLVS* 3,116,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 2.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg(F)/m3,KZG- week 4 mg(F)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air 10 hour time-weighted average 2.5 mg(F)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0579;
Number of Industries 17;
Total Number of Facilities 840;
Number of Occupations 22;
Total Number of Employees Exposed 17,561
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0579;
Number of Industries 187;
Total Number of Facilities 25,299;
Number of Occupations 76;
Total Number of Employees Exposed 344,071;
Total Number of Female Employees Exposed 3,195


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach 860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH.
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy of Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1946-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. (Rochester, NY)

Used for production of HYDROFLUORIC ACID and as a flux in steel manufacture

NIOSH PROFILE (ALUMINUM REDUCTION PLANTS), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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