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Registry of Toxic Effects of Chemical Substances (RTECS)

Calcium fluoride

RTECS #

EW1760000

CAS #

7789-75-5

Updated

September 201

Molecular Weight

78.08

Molecular Formula

CaF2

Synonyms

Acid-spar
Calcium difluoride
Fluorspar
Irtran 3
Liparite
Met-spar

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisAscites tumor/rat1 gm/kgGANNA2 54,155,1963

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 3200 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)DZZEA7 34,124,1979
intraperitoneal/mouse 67200 mg/kg (1-21D pregnant)Reproductive: Other developmental abnormalitiesDZZEA7 34,484,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mammal (species unspecified) Lethal dose: >10 gm/kgMTPEEI (7),32,1994
intraperitoneal/mouse lethal dose (50 percent kill): 2638 mg/kgDZZEA7 34,484,1979
intraperitoneal/rat lethal dose (50 percent kill): >1500 mg/kgXEURAQ UR-154,1951
oral/guinea pig Lethal dose: >5 gm/kgMEIEDD 11,253,1989
oral/rat lethal dose (50 percent kill): 4250 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VAMNAQ (2),28,1977
oral/rat lethal dose (50 percent kill): 4417 mg/kgVCVN5* -,354,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 44 gm/kg/31D- intermittentCardiac: EKG changes not diagnostic of above

Musculoskeletal: Changes in teeth and supporting structures

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
MTPEEI (7),32,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2.5 mg(F)/m3DTLVS* 3,116,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-ECtime-weighted average 2.5 mg(F)/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 2.5 mg(F)/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg(F)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 2.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2.5 mg(F)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2.5 mg(F)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2.5 mg(F)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2.5 mg(F)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2.5 mg(F)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air10H time-weighted average 2.5 mg(F)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0579; Number of Industries 187; Total Number of Facilities 25299; Number of Occupations 76; Total Number of Employees Exposed 344071; Total Number of Female Employees Exposed 3195
National Occupational Hazard Survey 1974Hazard Code M0579; Number of Industries 17; Total Number of Facilities 840; Number of Occupations 22; Total Number of Employees Exposed 17561

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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