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Registry of Toxic Effects of Chemical Substances (RTECS)

Calcium chloride

RTECS #

EV9800000

CAS #

10043-52-4

Updated

July 2013

Molecular Weight

110.98

Molecular Formula

CaCl2

Synonyms

Calplus
Caltac
Dowflake
Liquidow
Peladow
Snomelt
Superflake anhydrous

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisAscites tumor/rat3500 mg/kgGANNA2 54,155,1963
DNA Damageother cell types/mouse1.63 mmol/L/4H (-enzymatic activation step)EMMUEG 49,439,2008
DNA Damagekidney/rat0.81 mmol/L/4H (-enzymatic activation step)EMMUEG 49,439,2008
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae200 mmol/LMUTAEX 1,21,1986
Unscheduled DNA Synthesisintraperitoneal/rat2500 µmol/kgJOENAK 65,45,1975

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 112 gm/kg/20W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors
AJCAA7 23,550,1935

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 0.7 mmol/LGastrointestinal: Contraction (isolated tissue)FTRPAE 83,1286,2012
In Vitro/Rat, bladder Inhibitor Concentration Low: 2.5 mmol/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,201,1989
intraarterial/guinea pig lowest published lethal dose: 300 mg/kgAEPPAE 131,171,1928
intracerebral/mouse lowest published toxic dose: 44392 ng/kgBehavioral: Change in psychophysiological testsACPSI* 25,644,2004
intraduodenal/Dog lowest published toxic dose: 555 mg/kg/1HGastrointestinal: Alteration in gastric secretionAJPHAP 248,G28,1985
intramuscular/rat lethal dose (50 percent kill): 25 mg/kgEMSUA8 4,223,1946
intraperitoneal/mouse lethal dose (50 percent kill): 210 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
GTPZAB 34(5),51,1990
intraperitoneal/mouse lowest published lethal dose: 399.5 mg/kgJTCTDW 39,349,2001
intraperitoneal/mouse lethal dose (50 percent kill): 600 mg/kgVCVN1* -,118,1988
intraperitoneal/rat lethal dose (50 percent kill): 264 mg/kgOYYAA2 14,963,1977
intravenous/cat lowest published lethal dose: 249 mg/kgHBAMAK 4,1316,1935
intravenous/Dog lowest published lethal dose: 274 mg/kgHBAMAK 4,1316,1935
intravenous/Dog lowest published toxic dose: 39.95 mg/kg/15MGastrointestinal: Alteration in gastric secretionAJPHAP 248,G28,1985
intravenous/guinea pig lowest published lethal dose: 150 mg/kgAEPPAE 131,171,1928
intravenous/mouse lethal dose (50 percent kill): 42 mg/kgTXAPA9 22,150,1972
intravenous/rabbit lowest published lethal dose: 274 mg/kgHBAMAK 4,1316,1935
intravenous/rat lowest published lethal dose: 161 mg/kgJLCMAK 15,35,1929
intravenous/rat lowest published toxic dose: 300 mg/kgCardiac: Arrythmias (indlucing changes in conduction)FATOAO 51,50,1988
intravenous/woman lowest published toxic dose: 20 mg/kg/1H-continuousSkin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Changes in: Ca
ARDEAC 124,922,1988
oral/mouse lethal dose (50 percent kill): 1940 mg/kgOYYAA2 14,963,1977
oral/rabbit lowest published lethal dose: 1384 mg/kgHBAMAK 4,1316,1935
oral/rabbit lethal dose (50 percent kill): 1384 mg/kgVCVN1* -,118,1988
oral/rat lethal dose (50 percent kill): 1 gm/kgCNJMAQ 12,216,1948
parenteral/rat lowest published toxic dose: 200 µg/kgCardiac: Arrythmias (indlucing changes in conduction)PCJOAU 37,6,2003
subcutaneous/cat lowest published lethal dose: 249 mg/kgHBAMAK 4,1316,1935
subcutaneous/Dog lowest published lethal dose: 274 mg/kgHBAMAK 4,1316,1935
subcutaneous/frog lowest published lethal dose: 666 mg/kgHBAMAK 4,1316,1935
subcutaneous/mouse lethal dose (50 percent kill): 823 mg/kgOYYAA2 14,963,1977
subcutaneous/rabbit lowest published lethal dose: 472 mg/kgHBAMAK 4,1316,1935
subcutaneous/rat lethal dose (50 percent kill): 2630 mg/kgOYYAA2 14,963,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 43 mg/m3/4H/17W- intermittentBlood: Change in clotting factors

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GTPZAB 34(5),51,1990
oral/rat lowest published toxic dose: 2016 mg/kg/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Cardiac: Pulse rate decreased with fall in BP

Blood: Changes in leukocyte (WBC) count
GTPZAB 34(5),51,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWBJMRDK 34,449,2001
TOXICOLOGY REVIEWTPHSDY 23,63,2002
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,317,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 15720; Number of Industries 116; Total Number of Facilities 15168; Number of Occupations 113; Total Number of Employees Exposed 354620; Total Number of Female Employees Exposed 117433
National Occupational Hazard Survey 1974Hazard Code 15720; Number of Industries 87; Total Number of Facilities 7996; Number of Occupations 79; Total Number of Employees Exposed 110691

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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