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Cadmium sulfate (1:1)

RTECS #: EV2700000

CAS #: 10124-36-4


UPDATE: May 2009 MW: 208.46 MF: O4S•Cd


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Cadmium sulfate
  2. Cadmium sulphate
  1. Sulphuric acid, cadmium salt (1:1)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1 µmol/L MUREAV 265,45,1992
DNA damage human lymphocyte 500 µmol/L EMMUEG 23,299,1994
DNA damage human fibroblast 0.33 µmol/L/2 hour MUREAV 498,47,2001
DNA damage human lung 7.8 µmol/L/20 hour MUREAV 605,94,2006
DNA damage Neurospora crassa 10 µmol/L MUREAV 405,29,1998
DNA damage rat liver 30 µmol/L MUREAV 113,357,1983
DNA damage rat lung 31.2 µmol/L/20 hour MUREAV 605,94,2006
DNA damage oral
rat
140 mg/kg MUREAV 605,94,2006
DNA damage rat liver 5 µmol/L/3 hour MUREAV 629,49,2007
DNA repair Bacillus subtilis 5 mmol/L MUREAV 77,109,1980
DNA repair Escherichia coli 50 µg/well MUREAV 133,161,1984
micronucleus test hamster ovary 1.11 µmol/L/24 hour (-enzymatic activation step) MUREAV 630,1,2007
micronucleus test hamster ovary 3.33 µmol/L/3 hour (+enzymatic activation step) MUREAV 630,1,2007
micronucleus test human fibroblast 0.33 µmol/L/24 hour MUREAV 490,99,2001
micronucleus test intraperitoneal
mouse
4,300 µg/kg GWZHEW 12,77,1986
mutation in mammalian somatic cells mouse lymphocyte 150 µg/L JTEHD6 9,367,1982
other mutation test systems hamster ovary 1 µmol/L MUREAV 265,45,1992
sex chromosome loss and nondisjunction human lung 67 nmol/L MUREAV 469,35,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 2,800 µg/kg (8 day pregnant) Reproductive: Other developmental abnormalities TJADAB 29(2),30A,1984
intraperitoneal
mouse
lowest published toxic dose: 5,150 µg/kg (9 day pregnant) Reproductive: Other effects to embryo or fetus TJADAB 32,407,1985
intraperitoneal
mouse
lowest published toxic dose: 5,150 µg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 29,427,1984
intraperitoneal
mouse
lowest published toxic dose: 3 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 27,54A,1983
intraperitoneal
mouse
lowest published toxic dose: 1,030 µg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 29,427,1984
intraperitoneal
mouse
lowest published toxic dose: 2,570 µg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 29,427,1984
intravenous
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Central nervous system
BECTA6 22,175,1979
intravenous
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BECTA6 22,175,1979
intravenous
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Eye, ear
EXPEAM 25,56,1969
intravenous
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis
ENVRAL 6,95,1973
oral
rat
lowest published toxic dose: 35,230 mg/kg (1-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Maternal- fetal exchange
GISAAA 50(8),11,1985
oral
rat
lowest published toxic dose: 35,230 mg/kg (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
GISAAA 50(8),11,1985
parenteral
mouse
lowest published toxic dose: 28 µg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
IGSBAL 92,65,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 1 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
BCLPT* 94,112,2004
intraperitoneal
mouse
lethal dose (50 percent kill): 6,879 µg/kg N/R COREAF 256,1043,1963
oral
dog
lowest published lethal dose: 105 mg/kg N/R EQSSDX 1,1,1975
oral
mouse
lethal dose (50 percent kill): 47 mg/kg N/R VCVN1* -,164,1988
oral
rat
lethal dose (50 percent kill): 280 mg/kg N/R 41HTAH -,14,1978
subcutaneous
dog
lowest published lethal dose: 27 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
frog
lowest published lethal dose: 105 mg/kg N/R HBAMAK 4,1317,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 122 mg/kg/17 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
BCLPT* 94,112,2004
intraperitoneal
rat
lowest published toxic dose: 3.6 mg/kg/2 day- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Metabolism (intermediary): Other proteins
EXMPA6 55,97,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Cd)/m3 (respirable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 2,74,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 11,39,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,119,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,119,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,119,1993
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
43QNAO 2,743,1981
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
EMMUEG 43,36,2004
TOXICOLOGY REVIEW
ENTOX* -,375,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
NETEEC 29,425,2007
TOXICOLOGY REVIEW
HBTME* ,445,2007
TOXICOLOGY REVIEW
HBTME* ,177,2007
TOXICOLOGY REVIEW
HUTOX* -,515,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg(Cd)/m3 DTLVS* 3,34,1971
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg(Cd)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg(Cd)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.015 mg(Cd)/m3 (inhalable), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.03 mg(Cd)/m3 (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Cd)/m3 (resp. dust), Carcinogen, MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg(Cd)/m3 (inhal. dust), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cd)/m3 (fume, dust), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.02 mg(Cd)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cd)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.015 mg(Cd)/m3, short term exposure limit 0.06 mg(Cd)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Cd)/m3, group 1 carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.05 mg(Cd)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.002 mg(Cd)/m3 (inhalable), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.01 mg(Cd)/m3 (total dust), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.005 mg(Cd)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.01 mg(Cd)/m3 (inspirable dust), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.002 mg(Cd)/m3 (respirable dust), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Cd)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg(Cd)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) dust 0.04 mg(Cd)/m3, MAC(short term exposure limit) dust 0.2 mg(Cd)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) fume 0.02 mg(Cd)/m3, MAC(short term exposure limit) fume 0.05 mg(Cd)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.01 mg(Cd)/m3, short term exposure limit 0.05 mg(Cd)/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.02 mg(Cd)/m3 (total dust), Carcinogen, JUN2005
Occupational Exposure Limit - SWEDEN time-weighted average 0.005 mg(Cd)/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.015 mg(Cd)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg(Cd)/m3, short term exposure limit 0.5 mg(Cd)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Cd)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.025 mg(Cd)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CADMIUM, dust and fume-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80247;
Number of Industries 5;
Total Number of Facilities 1,041;
Number of Occupations 5;
Total Number of Employees Exposed 15,328
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80247;
Number of Industries 5;
Total Number of Facilities 79;
Number of Occupations 4;
Total Number of Employees Exposed 1,313;
Total Number of Female Employees Exposed 172


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of cadmium salts of long-chain fatty acids for plastic stabilizers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii Inst., 1978
43QNAO "Cadmium in the Environment," Nriagu, J.O., ed., 2 vols., New York, John Wiley & Sons, Inc., 1980-81
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GWZHEW Gongye Weisheng Yu Zhiyebing. Industrial Health and Occupational Diseases. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1973-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTME*
HUTOX*
IGSBAL Igaku to Seibutsugaku. Medicine and Biology. (c/o Ogato Igaku Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103, Japan) V.1- 1942-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in the manufacture of cadmium salts of long-chain fatty acids for plastic stabilizers

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 31119-53-6
ALT CAS #: 62642-07-3
Click Here for Additional Information about RTECS

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