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Cadmium

RTECS #: EU9800000

CAS #: 7440-43-9


UPDATE: May 2009 MW: 112.40 MF: Cd


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. C.I. 77180
  2. Cadmium (ACGIH:OSHA)
  3. Cadmium dust fume (OSHA)
  4. Cadmium powder
  1. Cadmium, elemental
  2. Colloidal cadmium
  3. Kadmium (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1 mol/L CGCGBR 26,251,1980
DNA damage human lung 10 mol/L TOXID9 72,219,2003
DNA damage human lymphocyte 250 mol/L/1 hour TOXID9 12,430,2008
DNA damage mouse fibroblast 5 nmol/L/24 hour TOXID9 44,237,2005
micronucleus test mouse embryo 6 mol/L TIVIEQ 4,57,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 1,686 g/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 28,39A,1983
intraperitoneal
rat
lowest published toxic dose: 1,124 g/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 41,194,1977
intravenous
rat
lowest published toxic dose: 1,250 g/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Urogenital system
JJATDK 1,264,1981
intravenous
rat
lowest published toxic dose: 1,250 g/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
JJATDK 1,264,1981
intravenous
rat
lowest published toxic dose: 8 mg/kg (8-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JJATDK 1,264,1981
oral
mouse
lowest published toxic dose: 448 mg/kg (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
AEHLAU 23,102,1971
oral
mouse
lowest published toxic dose: 1,700 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 6,361,1986
oral
mouse
lowest published toxic dose: 62 mg/kg (1 day pregnant-10 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 228,77,2006
oral
rat
lowest published toxic dose: 155 mg/kg (13 week male/13 week prior to copulation-3 week pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
BECTA6 20,96,1978
oral
rat
lowest published toxic dose: 220 mg/kg (1-22 day pregnant) Reproductive: Other effects to embryo or fetus TOLED5 11,233,1982
oral
rat
lowest published toxic dose: 21,500 g/kg (multigenerations) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on newborn: Germ cell effects (in offspring)
ENVRAL 22,466,1980
oral
rat
lowest published toxic dose: 23 mg/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) PSEBAA 158,614,1978
parenteral
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 31,52A,1985
subcutaneous
rat
lowest published toxic dose: 250 g/kg (19 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic APTOD9 19,A122,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
woman
lowest published toxic concentration: 129 g/m3/20 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AJIMD8 10,153,1986
intramuscular
rat
lowest published toxic dose: 40 mg/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
JEPTDQ 1(1),51,1977
intramuscular
rat
toxic dose : 70 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
BJCAAI 18,124,1964
intramuscular
rat
toxic dose : 63 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
NATUAS 193,592,1962
intramuscular
rat
toxic dose : 45 mg/kg/4 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
NCIUS* PH43-64-886
subcutaneous
rat
lowest published toxic dose: 3,372 g/kg Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
ENVRAL 55,40,1991
unreported route
rat
lowest published toxic dose: 1,200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors

Tumorigenic: Tumors at site of application
ZHYGAM 31,224,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published lethal concentration: 39 mg/m3/20 minute Cardiac: Other changes

Vascular: Thromobosis distant from injection site

Lung, Thorax, or Respiration: Respiratory depression
AIHAAP 31,180,1970
inhalation
man
lowest published toxic concentration: 88 g/m3/8.6 year Kidney, Ureter, and Bladder: Proteinuria AEHLAU 28,147,1974
inhalation
rat
lethal concentration (50 percent kill): 25 mg/m3/30 minute Lung, Thorax, or Respiration: Dyspnea SAIGBL 16,212,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 5,700 g/kg N/R TXAPA9 37,403,1976
intravenous
rabbit
lowest published lethal dose: 5 mg/kg N/R JOBSAK 35,693,1928
intravenous
rabbit
lethal dose : 2.5 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Blood: Granulocytopenia
TXAPA9 174,225,2001
intravenous
rabbit
lethal dose : 3.5 mg/kg Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Blood: Granulocytopenia
TXAPA9 174,225,2001
intravenous
rabbit
lowest published toxic dose: 4 mg/kg Eye: Other eye effects TOXID9 66,206,2002
oral
mouse
lethal dose (50 percent kill): 890 mg/kg N/R VCVN1* -,164,1988
oral
mouse
lowest published toxic dose: 8 mg/kg Musculoskeletal: Osteoporosis

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,53,2004
oral
rat
lethal dose (50 percent kill): 2,330 mg/kg N/R 85PDAD -,67,1978
oral
rabbit
lowest published lethal dose: 70 mg/kg N/R AMPMAR 34,127,1973
parenteral
rat
lethal dose : 5 mg/kg N/R TOXID9 66,202,2002
subcutaneous
rabbit
lowest published lethal dose: 6 mg/kg N/R PROTA* -,-,1955
skin
mouse
lowest published lethal dose: 77.5 mg/kg N/R TXAPA9 176,24,2001
unreported route
man
lowest published lethal dose: 15 mg/kg N/R 85DCAI 2,73,1970
unreported route
mouse
lethal dose (50 percent kill): 890 mg/kg N/R GTPZAB 22(5),6,1978
unreported route
rat
lethal dose (50 percent kill): 1,140 mg/kg N/R GTPZAB 22(5),6,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
: 15 mg/kg/15 day- intermittent Cardiac: Other changes

Vascular: BP elevation not characterized in autonomic section

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 227,15,2006
multiple
man
lowest published toxic dose: 0.355 gm/kg/30 year- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition
JAPTO* 22,431,2002
multiple
woman
lowest published toxic dose: 0.498 gm/kg/30 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition JAPTO* 22,431,2002
oral
human
lowest published toxic dose: 53.6 mg/kg/50 year- continuous Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes
JJATDK 22,431,2002
oral
mouse
lowest published toxic dose: 504 mg/kg/6 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 197,269,2004
oral
mouse
lowest published toxic dose: 210 mg/kg/15 week- continuous Kidney, Ureter, and Bladder: Proteinuria TOXID9 66,80,2002
oral
mouse
lowest published toxic dose: 1,302 g/kg/31 week- continuous Blood: Changes in spleen

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Autoimmune (multiple organ involvement)
TOXID9 66,80,2002
oral
pig
lowest published toxic dose: 21,880 mg/kg/78 week- continuous Vascular: BP elevation not characterized in autonomic section TOXID9 13,162,1993
oral
rat
lowest published toxic dose: 546 mg/kg/26 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 2,52,1982
oral
rat
lowest published toxic dose: 1,512 mg/kg/48 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
TOLED5 5,105,1980
oral
rat
lowest published toxic dose: 37.5 mg/kg/30 day- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,17,2003
oral
rat
lowest published toxic dose: 420 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 42,429,2004
oral
rat
lowest published toxic dose: 3,780 mg/kg/9 week- continuous Immunological Including Allergic: Autoimmune (multiple organ involvement) TOXID9 66,80,2002
oral
rat
lowest published toxic dose: 150 mg/kg/30 day- continuous Eye: Other eye effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Effect on Na-K pump
RJENT* 1,204,2007
oral
woman
lowest published toxic dose: 75 mg/kg/40 year- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
JJATDK 22,431,2002
subcutaneous
rat
lowest published toxic dose: 15 mg/kg/5 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria
TOXID9 72,349,2003
subcutaneous
rat
lowest published toxic dose: 15 mg/kg/5 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
TOXID9 -,77,2008
subcutaneous
rat
lowest published toxic dose: 24 mg/kg/8 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOXID9 -,77,2008
subcutaneous
rat
lowest published toxic dose: 30 mg/kg/10 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOXID9 -,77,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 2,74,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 11,39,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,119,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMSUDL 7,139,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 58,119,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,119,1993
TOXICOLOGY REVIEW
MUREAV 540,19,2003
TOXICOLOGY REVIEW
JDSCAE 58,1767,1975
TOXICOLOGY REVIEW
JFDSAZ 39,321,1974
TOXICOLOGY REVIEW
TXAPA9 197,144,2004
TOXICOLOGY REVIEW
AMBOCX 3,55,1974
TOXICOLOGY REVIEW
QURBAW 7,75,1974
TOXICOLOGY REVIEW
AEMBAP 40,239,1973
TOXICOLOGY REVIEW
NTIS** PB221-198
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
STEVA8 2,341,1974
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
ENVRAL 4,71,1971
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
PDTNBH 6,204,1977
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
GSAMAQ 123,109,1971
TOXICOLOGY REVIEW
49DXAV -,57,1983
TOXICOLOGY REVIEW
43QNAO 2,743,1981
TOXICOLOGY REVIEW
CREOH* 42,93,2002
TOXICOLOGY REVIEW
TOLED5 127,63,2002
TOXICOLOGY REVIEW
TOLED5 134,17,2002
TOXICOLOGY REVIEW
TOLED5 140-141,53,2003
TOXICOLOGY REVIEW
TOLED5 140-141,161,2003
TOXICOLOGY REVIEW
TOLED5 140-141,311,2003
TOXICOLOGY REVIEW
MAERE* 51,247,2001
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MAERE* 52,173,2001
TOXICOLOGY REVIEW
CRTXB2 33,215,2003
TOXICOLOGY REVIEW
TXAPA9 207,179,2005
TOXICOLOGY REVIEW
REPTED 22,196,2006
TOXICOLOGY REVIEW
REPTED 22,164,2006
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
NRTXDN 27,429,2006
TOXICOLOGY REVIEW
MUREAV 613,76,2006
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
ENTOX* -,375,2005
TOXICOLOGY REVIEW
JJATDK 26,191,2006
TOXICOLOGY REVIEW
HETOEA 25,67,2006
TOXICOLOGY REVIEW
TOPADD 32(Suppl. 2),71,2004
TOXICOLOGY REVIEW
JTEHD6 6,227,2003
TOXICOLOGY REVIEW
MUREAV 533,107,2003
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
MUREAV 544,305,2003
TOXICOLOGY REVIEW
REPTED 23,297,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
HBTME* ,445,2007
TOXICOLOGY REVIEW
HBTME* ,445,2007
TOXICOLOGY REVIEW
MUREAV 544,313,2003
TOXICOLOGY REVIEW
HTOPA* 1,701,2002
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
HUTOX* -,515,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) see Code of Federal Regulations (CFR) 29,1910.1027 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1127 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) see Code of Federal Regulations (CFR) 29,1915.1027 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg(Cd)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.015 mg(Cd)/m3 (inhalable), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.015 mg/m3 (inhalable), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.03 mg(Cd)/m3 (inhalable), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.03 mg/m3 (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg/m3 (resp. dust), Carcinogen, MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg/m3 (inhal. dust), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg/m3 (fume, dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cd)/m3 (fume, dust), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.02 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 mg/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.015 mg/m3, short term exposure limit 0.06 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg/m3, group 1 carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.01 mg/m3 (total dust), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.002 mg/m3 (inhalable), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.002 mg(Cd)/m3 (inhalable), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.005 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.01 mg(Cd)/m3 (inspirable dust), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.002 mg(Cd)/m3 (respirable dust), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) dust 0.04 mg/m3, MAC(short term exposure limit) dust 0.2 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) fume 0.02 mg/m3, MAC(short term exposure limit) fume 0.05 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.01 mg/m3, short term exposure limit 0.05 mg/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.02 mg/m3(total dust);
time-weighted average 0.005 mg/m3(resp. dust), Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.015 mg/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg/m3, short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.025 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CADMIUM, dust and fume-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0608;
Number of Industries 1;
Total Number of Facilities 48;
Number of Occupations 1;
Total Number of Employees Exposed 96
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 15570;
Number of Industries 41;
Total Number of Facilities 1,256;
Number of Occupations 50;
Total Number of Employees Exposed 14,717
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0608;
Number of Industries 2;
Total Number of Facilities 25;
Number of Occupations 3;
Total Number of Employees Exposed 335;
Total Number of Female Employees Exposed 22
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2776;
Number of Industries 5;
Total Number of Facilities 248;
Number of Occupations 6;
Total Number of Employees Exposed 3,893;
Total Number of Female Employees Exposed 1,887
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5979;
Number of Industries 2;
Total Number of Facilities 95;
Number of Occupations 2;
Total Number of Employees Exposed 486
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 15570;
Number of Industries 77;
Total Number of Facilities 4,811;
Number of Occupations 64;
Total Number of Employees Exposed 88,968;
Total Number of Female Employees Exposed 14,541


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166621)
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in metal plating, for plastic stabilizers and in pigments
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 42, 1984
NIOSH Analytical Method, 1994: Cadmium and compounds, as Cd, 7048
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID189
OSHA ANALYTICAL METHOD #ID206


REFERENCES:

CODEN
REFERENCE

43QNAO "Cadmium in the Environment," Nriagu, J.O., ed., 2 vols., New York, John Wiley & Sons, Inc., 1980-81
49DXAV "Health Evaluation of Heavy Metals in Infant Formula and Junior Food, Proceedings of the Symposium, 1981," Schmidt, E.H.F., and A.G. Hildebrandt, eds., Berlin, Springer-Verlag, 1983
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man", Oxford, UK. Pergamon Press Ltd., 1978
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
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HBTME*
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HTOPA*
HUTOX*
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ITODC*
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RJENT*
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Used in metal plating, for plastic stabilizers and in pigments

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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