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3 - Butyn - 2 - ol, 2 - methyl -

RTECS #: ES0810000

CAS #: 115-19-5

UPDATE: August 2006 MW: 84.13 MF: C5H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. STANDARDS AND REGULATIONS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylpropargyl alcohol
  2. 1,1 - Dimethylpropynol
  3. 1 - Butyn - 3 - ol, 3 - methyl -
  4. 2 - Hydroxy - 2 - methyl - 3 - butyne
  5. 2 - Methylbutyn - 3 - ol - 2
  6. 2 - Methyl - 3 - butyn - 2 - ol
  7. 3 - Methyl - butin - (1) - ol - (3) (German)
  8. 3 - Methyl - 1 - butyn - 3 - ol
  1. Dimethylacetylenecarbinol
  2. Dimethylacetylenylcarbinol
  3. Dimethylethynylcarbinol
  4. Dimethylethynylmethanol
  5. Ethynyldimethylcarbinol
  6. MBY
  7. alpha,alpha - Dimethylpropargyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 2 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		GTPZAB 31(4),55,1987
inhalation
mouse 		lethal concentration (50 percent kill): 2,000 mg/m3 Lung, Thorax, or Respiration: Respiratory depression

Behavioral: General anesthetic

Behavioral: Ataxia 		VCVGK* -,125,1984
oral
mouse 		lethal dose (50 percent kill): 500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		GTPZAB 31(4),55,1987
oral
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R VCVGK* -,125,1984
oral
rat 		lethal dose (50 percent kill): 1,950 mg/kg N/R JPETAB 115,230,1955
subcutaneous
mouse 		lethal dose (50 percent kill): 1,161 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		YKKZAJ 76,181,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 3 mg/m3 (0.9 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1058;
Number of Industries 2;
Total Number of Facilities 67;
Number of Occupations 5;
Total Number of Employees Exposed 3,234;
Total Number of Female Employees Exposed 2,672


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in organic syntheses, stabilizer for chlorinated solvents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used as intermediate in organic syntheses, stabilizer for chlorinated solvents

RTECS Compound Description:
   Drug

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