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2 - Butyne - 1,4 - diol

RTECS #: ES0525000

CAS #: 110-65-6


UPDATE: February 2008 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Butin - 1,4 - diol (Czech)
  2. Agrisynth B3D
  1. Bis (hydroxymethyl) acetylene
  2. Butynediol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 880 mg/kg (5-15 day pregnant) Reproductive: Other effects on female NTIS** OTS0557862
oral
rat
lowest published toxic dose: 800 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 92,221,1997


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation VCVGK* -,153,1984
inhalation
mouse
lowest published lethal concentration: 0.21 gm/m3/2 hour Eye: Lacrimation

Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
TPKVAL 7,13,1965
inhalation
mouse
lowest published toxic concentration: 0.11 gm/m3/2 hour Brain and Coverings: Changes in circulation

Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 7,13,1965
intraperitoneal
rat
lethal dose (50 percent kill): 52,435 g/kg N/R JPPMAB 26,597,1974
ocular
rabbit
lowest published toxic dose: 30 pph Eye: Conjunctiva irritation TPKVAL 7,13,1965
oral
wild bird
lethal dose (50 percent kill): 75 mg/kg N/R AECTCV 12,355,1983
oral
guinea pig
lethal dose (50 percent kill): 130 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
guinea pig
lethal dose (50 percent kill): 130 mg/kg N/R VCVGK* -,153,1984
oral
mouse
lethal dose (50 percent kill): 105 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
mouse
lethal dose (50 percent kill): 100 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
TPKVAL 7,13,1965
oral
mouse
lethal dose (70 percent kill): 150 mg/kg Brain and Coverings: Changes in circulation TPKVAL 7,13,1965
oral
mouse
lethal dose : 200 mg/kg Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 7,13,1965
oral
rat
lethal dose (50 percent kill): 105 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
rat
lethal dose (50 percent kill): 100 mg/kg N/R VCVGK* -,153,1984
oral
rat
lethal dose (50 percent kill): 100 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 7,13,1965
oral
rat
lethal dose (70 percent kill): 150 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TPKVAL 7,13,1965
oral
rat
lethal dose : 200 mg/kg Skin: After topical application: Primary irritation TPKVAL 7,13,1965
oral
rabbit
lethal dose (50 percent kill): 150 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
rabbit
lethal dose (50 percent kill): 150 mg/kg N/R VCVGK* -,153,1984
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
VCVGK* -,153,1984
skin
rabbit
lowest published toxic dose: 30 pph/2 hour Skin: After topical application: Primary irritation TPKVAL 7,13,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 0.11 gm/m3/2 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 7,13,1965
inhalation
mouse
lowest published toxic concentration: 0.11 gm/m3/18 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,13,1965
inhalation
rat
lowest published toxic concentration: 80 mg/m3/4 hour/60 day- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,153,1994
inhalation
rat
lowest published toxic concentration: 8 mg/m3/4 hour/28 week- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,153,1994
inhalation
rat
lowest published toxic concentration: 8 mg/m3/4 hour/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Vascular: BP lowering not characterized in autonomic section

Liver: Liver function tests impaired
TPKVAL 7,13,1965
inhalation
rat
lowest published toxic concentration: 0.9 gm/m3/122 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 7,13,1965
inhalation
rat
lowest published toxic concentration: 0.9 gm/m3/0.5 year- intermittent Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Liver function tests impaired
TPKVAL 7,13,1965
oral
rat
lowest published toxic dose: 1,400 mg/kg/28 day- intermittent Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JJATDK 12,117,1992
oral
rat
lowest published toxic dose: 364 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other carbohydrates
GISAAA 33(1),37,1968
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 43,87,1989
skin
rabbit
lowest published toxic dose: 100 pph/10 day- intermittent Skin: After topical application: Dermatitis, allergic TPKVAL 7,13,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - GERMANY MAK 0.2 mg/m3 (inhalable, skin, sen), 2005
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3;
KZG- week 0.2 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2524;
Number of Industries 7;
Total Number of Facilities 307;
Number of Occupations 11;
Total Number of Employees Exposed 2,173
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2524;
Number of Industries 21;
Total Number of Facilities 1,139;
Number of Occupations 20;
Total Number of Employees Exposed 16,527;
Total Number of Female Employees Exposed 4,755


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as corrosion inhibitor in acid pickling, brightener in NICKEL electroplating
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as corrosion inhibitor in acid pickling, brightener in NICKEL electroplating

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

Click Here for Additional Information about RTECS

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