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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Butyne-1,4-diol

RTECS #

ES0525000

CAS #

110-65-6

Updated

July 2013

Molecular Weight

86.10

Molecular Formula

C4H6O2

Synonyms

2-Butin-1,4-diol (Czech)
Agrisynth B3D
Bis(hydroxymethyl)acetylene
Butynediol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 30%/2HTPKVAL 7,13,1965

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 880 mg/kg (5-15D pregnant)Reproductive: Other effects on femaleNTIS** OTS0557862
oral/rat 800 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 92,221,1997

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationVCVGK* -,153,1984
inhalation/mouse Lowest published lethal concentration: 0.21 gm/m3/2HEye: Lacrimation

Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
TPKVAL 7,13,1965
inhalation/mouse lowest published toxic concentration: 0.11 gm/m3/2HBrain and Coverings: Changes in circulation

Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 7,13,1965
intraperitoneal/rat lethal dose (50 percent kill): 52435 µg/kgJPPMAB 26,597,1974
ocular/rabbit lowest published toxic dose: 30 pphEye: Conjunctiva irritationTPKVAL 7,13,1965
oral/guinea pig lethal dose (50 percent kill): 130 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/guinea pig lethal dose (50 percent kill): 130 mg/kgVCVGK* -,153,1984
oral/mouse lethal dose (50 percent kill): 105 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/mouse lowest published lethal dose: 200 mg/kgEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 7,13,1965
oral/mouse lethal dose (50 percent kill): 100 mg/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
TPKVAL 7,13,1965
oral/mouse lethal dose (70 percent kill): 150 mg/kgBrain and Coverings: Changes in circulationTPKVAL 7,13,1965
oral/rabbit lethal dose (50 percent kill): 150 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/rabbit lethal dose (50 percent kill): 150 mg/kgVCVGK* -,153,1984
oral/rat lethal dose (50 percent kill): 105 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/rat lethal dose (50 percent kill): 100 mg/kgVCVGK* -,153,1984
oral/rat lethal dose (50 percent kill): 100 mg/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 7,13,1965
oral/rat lethal dose (70 percent kill): 150 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TPKVAL 7,13,1965
oral/rat lowest published lethal dose: 200 mg/kgSkin: After topical application: Primary irritationTPKVAL 7,13,1965
oral/wild bird lethal dose (50 percent kill): 75 mg/kgAECTCV 12,355,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 0.11 gm/m3/2W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 7,13,1965
inhalation/mouse lowest published toxic concentration: 0.11 gm/m3/18D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,13,1965
inhalation/rat lowest published toxic concentration: 0.009 gm/m3/122D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,13,1965
inhalation/rat lowest published toxic concentration: 0.009 gm/m3/0.5Y- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Liver function tests impaired
TPKVAL 7,13,1965
inhalation/rat lowest published toxic concentration: 80 mg/m3/4H/60D- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,153,1994
inhalation/rat lowest published toxic concentration: 8 mg/m3/4H/28W- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,153,1994
inhalation/rat lowest published toxic concentration: 8 mg/m3/4H/26W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Vascular: BP lowering not characterized in autonomic section

Liver: Liver function tests impaired
TPKVAL 7,13,1965
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentLiver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JJATDK 12,117,1992
oral/rat lowest published toxic dose: 364 mg/kg/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other carbohydrates
GISAAA 33(1),37,1968
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 43,87,1989

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 0.1 ppm (0.36 mg/m3), 2011
Occupational Exposure Limit-GERMANYMAK 0.2 mg/m3, inhal, skin, sen, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.2 mg/m3, inhal, skin, sen, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M2524; Number of Industries 21; Total Number of Facilities 1139; Number of Occupations 20; Total Number of Employees Exposed 16527; Total Number of Female Employees Exposed 4755
National Occupational Hazard Survey 1974Hazard Code M2524; Number of Industries 7; Total Number of Facilities 307; Number of Occupations 11; Total Number of Employees Exposed 2173

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
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