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Registry of Toxic Effects of Chemical Substances (RTECS)

Butyric acid

RTECS #

ES5425000

CAS #

107-92-6

Updated

April 2012

Molecular Weight

88.12

Molecular Formula

C4H8O2

Synonyms

1-Propanecarboxylic acid
Butanic acid
Butanoic acid
Buttersaeure (German)
Ethylacetic acid
Kyselina maselna (Czech)
n-Butyric acid
Propylformic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test moderateUCDS** 4/10/1968
skin /rabbit 20 mg/24H moderate85JCAE -,306,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA DamageHeLa cell/human3 mmol/LCELLB5 12,855,1977
DNA Damagefibroblast/chicken2 mmol/LCELLB5 12,855,1977
DNA inhibitionlymphocyte/human4 mmol/LHAONDL 2,381,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 39 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mouse Lethal concentration: >500 mg/m3Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchiGISAAA 23(5),31,1958
inhalation/rabbit lethal concentration (50 percent kill): >40 gm/m3ENTOX* -,368,2005
inhalation/rat Lethal concentration: >500 mg/m3Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchiTPKVAL 4,19,1962
intraperitoneal/mouse lethal dose (50 percent kill): 3180 mg/kgJPPMAB 21,85,1969
intravenous/mouse lethal dose (50 percent kill): 800 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPTOA6 18,141,1961
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 4,19,1962
oral/mouse lethal dose (50 percent kill): 1250 mg/kgTPKVAL 9,27,1967
oral/mouse lowest published lethal dose: 1000 mg/kgTPKVAL 4,19,1962
oral/mouse lowest published lethal dose: 500 mg/kgGastrointestinal: Necrotic changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
TPKVAL 4,19,1962
oral/rat lowest published lethal dose: 1000 mg/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiTPKVAL 4,19,1962
oral/rat lethal dose (50 percent kill): 1500 mg/kgTPKVAL 9,27,1967
skin/rabbit lethal dose (50 percent kill): 530 mg/kgENTOX* -,368,2005
skin/rabbit lethal dose (50 percent kill): 530 µL/kgUCDS** 4/10/1968
subcutaneous/mouse lethal dose (50 percent kill): 3180 mg/kgJPPMAB 21,85,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.4 gm/m3/2W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 4,19,1962
inhalation/rat lowest published toxic concentration: 0.4 gm/m3/30D- intermittentLung, Thorax, or Respiration: Other changesTPKVAL 4,19,1962
inhalation/rat lowest published toxic concentration: 0.15 gm/m3/213D- intermittentLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Fatty liver degeneration

Blood: Changes in spleen
TPKVAL 4,19,1962
oral/hamster lowest published toxic dose: 14 gm/kg/7D- continuousGastrointestinal: Other changesFCTOD7 29,367,1991
oral/mouse lowest published toxic dose: 33600 mg/kg/7D- continuousGastrointestinal: Other changesFCTOD7 29,367,1991
oral/rat lowest published toxic dose: 14 gm/kg/7D- continuousGastrointestinal: Other changesFCTOD7 29,367,1991

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAMIHAB 21,100,1960
TOXICOLOGY REVIEWENTOX* -,368,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84458; Number of Industries 7; Total Number of Facilities 333; Number of Occupations 27; Total Number of Employees Exposed 11600; Total Number of Female Employees Exposed 3391
National Occupational Hazard Survey 1974Hazard Code 84458; Number of Industries 6; Total Number of Facilities 113; Number of Occupations 12; Total Number of Employees Exposed 1747

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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