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Butyric acid

RTECS #: ES5425000

CAS #: 107-92-6


UPDATE: February 2008 MW: 88.12 MF: C4H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Propanecarboxylic acid
  2. Butanic acid
  3. Butanoic acid
  4. Buttersaeure (German)
  1. Ethylacetic acid
  2. Kyselina maselna (Czech)
  3. Propylformic acid
  4. n - Butyric acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test moderate UCDS** 4/10/1968
skin
rabbit
20 mg/24 hour moderate 85JCAE -,306,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage chicken fibroblast 2 mmol/L CELLB5 12,855,1977
DNA damage human HeLa cell 3 mmol/L CELLB5 12,855,1977
DNA inhibition human lymphocyte 4 mmol/L HAONDL 2,381,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration : >500 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi GISAAA 23(5),31,1958
inhalation
rat
lethal concentration : >500 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TPKVAL 4,19,1962
inhalation
rabbit
lethal concentration (50 percent kill): >40 gm/m3 N/R ENTOX* -,368,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
intravenous
mouse
lethal dose (50 percent kill): 800 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Lacrimation

Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 4,19,1962
oral
mouse
lowest published lethal dose: 500 mg/kg Gastrointestinal: Necrotic changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
TPKVAL 4,19,1962
oral
mouse
lethal dose : 1,000 mg/kg N/R TPKVAL 4,19,1962
oral
mouse
lethal dose (50 percent kill): 1,250 mg/kg N/R TPKVAL 9,27,1967
oral
rat
lethal dose : 1,000 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TPKVAL 4,19,1962
oral
rat
lethal dose (50 percent kill): 1,500 mg/kg N/R TPKVAL 9,27,1967
subcutaneous
mouse
lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
skin
mouse
lowest published toxic dose: 100 pph/30 minute Behavioral: Somnolence (general depressed activity)

Skin: After topical application: Corrosive
TPKVAL 4,19,1962
skin
rabbit
lethal dose (50 percent kill): 530 ÁL/kg N/R UCDS** 4/10/1968
skin
rabbit
lethal dose (50 percent kill): 530 mg/kg N/R ENTOX* -,368,2005
skin
rabbit
lowest published toxic dose: 100 pph/1 hour Skin: After topical application: Corrosive TPKVAL 4,19,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/2 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 4,19,1962
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/30 day- intermittent Lung, Thorax, or Respiration: Other changes TPKVAL 4,19,1962
inhalation
rat
lowest published toxic concentration: 0.15 gm/m3/213 day- intermittent Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Fatty liver degeneration

Blood: Changes in spleen
TPKVAL 4,19,1962
oral
hamster
lowest published toxic dose: 14 gm/kg/7 day- continuous Gastrointestinal: Other changes FCTOD7 29,367,1991
oral
mouse
lowest published toxic dose: 33,600 mg/kg/7 day- continuous Gastrointestinal: Other changes FCTOD7 29,367,1991
oral
rat
lowest published toxic dose: 14 gm/kg/7 day- continuous Gastrointestinal: Other changes FCTOD7 29,367,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
AMIHAB 21,100,1960
TOXICOLOGY REVIEW
ENTOX* -,368,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84458;
Number of Industries 6;
Total Number of Facilities 113;
Number of Occupations 12;
Total Number of Employees Exposed 1,747
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84458;
Number of Industries 7;
Total Number of Facilities 333;
Number of Occupations 27;
Total Number of Employees Exposed 11,600;
Total Number of Female Employees Exposed 3,391


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of esters
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CELLB5 Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA 02142) V.1- 1974-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HAONDL Hematological Oncology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.Sussex, PO19 1UD, UK) V.1- 1983-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the manufacture of esters

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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