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Registry of Toxic Effects of Chemical Substances (RTECS)

Butyraldehyde, 3-methyl-

RTECS #

ES3450000

CAS #

590-86-3

Updated

July 2011

Molecular Weight

86.15

Molecular Formula

C5H10O

Synonyms

1-Butanal, 3-methyl-
2-Methylbutanal-4
3-Methylbutanal
3-Methylbutyraldehyde
Aldehyde isovalerianique (French)
Isoamyl aldehyde
Isopentaldehyde
Isovaleral
Isovaleraldehyde
Isovaleric aldehyde

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,271,1986
skin /rabbit 500 mg/24H mild85JCAE -,271,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 50770 mg/m3Eye: Other eye effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes
GTPZAB 27(5),60,1983
inhalation/mouse lethal concentration (50 percent kill): 47700 mg/m3/2HBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,377,1984
inhalation/mouse lethal concentration (50 percent kill): 50770 mg/m3/2HBrain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
TOVEFN (6),39,2001
inhalation/mouse lethal concentration (50 percent kill): 50770 mg/m3/2HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
TOVEFN (6),39,2001
inhalation/mouse lethal concentration (50 percent kill): 50770 mg/m3/2HKidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidneyTOVEFN (6),39,2001
inhalation/rat lethal concentration (50 percent kill): 90860 mg/m3/4HBrain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
TOVEFN (6),39,2001
inhalation/rat lethal concentration (50 percent kill): 90860 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
TOVEFN (6),39,2001
inhalation/rat lethal concentration (50 percent kill): 90860 mg/m3/4HKidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidneyTOVEFN (6),39,2001
inhalation/rat lethal concentration (50 percent kill): 30860 mg/m3Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,377,1984
inhalation/rat lethal concentration (50 percent kill): 42700 mg/m3/4HBehavioral: Altered sleep time (including change in righting reflex)

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0535072
intraperitoneal/rat lowest published lethal dose: 800 mg/kgCSCIAE 61,451,1981
ocular/mammal (species unspecified) lowest published toxic dose: 100 pphEye: Conjunctiva irritationTOVEFN (6),39,2001
oral/guinea pig lethal dose (50 percent kill): 2950 mg/kgTOVEFN (6),39,2001
oral/mouse lethal dose (50 percent kill): 4750 mg/kgTOVEFN (6),39,2001
oral/rat lethal dose (50 percent kill): 5165 mg/kgTOVEFN (6),39,2001
oral/rat lethal dose (50 percent kill): 5600 mg/kgBehavioral: Somnolence (general depressed activity)GTPZAB 31(12),53,1987
oral/rat lethal dose (16 percent kill): 2460 mg/kgVCVGK* -,377,1984
oral/rat lethal dose (84 percent kill): 9300 mg/kgVCVGK* -,377,1984
skin/guinea pig lethal dose (50 percent kill): >8 gm/kgFCTOD7 26,379,1988
skin/rabbit lethal dose (50 percent kill): 3180 µL/kgLiver: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0535072
subcutaneous/mouse lowest published lethal dose: 2 gm/kgAPFRAD 14,710,1956

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (39 mg/m3);KZW 10 ppm (39 mg/m3), 2007
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
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