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Butyraldehyde, 3 - methyl -

RTECS #: ES3450000

CAS #: 590-86-3


UPDATE: February 2007 MW: 86.15 MF: C5H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1 - Butanal, 3 - methyl -
  2. 2 - Methylbutanal - 4
  3. 3 - Methylbutanal
  4. 3 - Methylbutyraldehyde
  5. Aldehyde isovalerianique (French)
  1. Isoamyl aldehyde
  2. Isopentaldehyde
  3. Isovaleral
  4. Isovaleraldehyde
  5. Isovaleric aldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,271,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,271,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 50,770 mg/m3 Eye: Other eye effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes
GTPZAB 27(5),60,1983
inhalation
mouse
lethal concentration (50 percent kill): 47,700 mg/m3/2 hour Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,377,1984
inhalation
mouse
lethal concentration (50 percent kill): 50,770 mg/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
TOVEFN (6),39,2001
inhalation
mouse
lethal concentration (50 percent kill): 50,770 mg/m3/2 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
TOVEFN (6),39,2001
inhalation
mouse
lethal concentration (50 percent kill): 50,770 mg/m3/2 hour Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney TOVEFN (6),39,2001
inhalation
rat
lethal concentration (50 percent kill): 42,700 mg/m3/4 hour Behavioral: Altered sleep time (including change in righting reflex)

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0535072
inhalation
rat
lethal concentration (50 percent kill): 30,860 mg/m3 Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,377,1984
inhalation
rat
lethal concentration (50 percent kill): 90,860 mg/m3/4 hour Brain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
TOVEFN (6),39,2001
inhalation
rat
lethal concentration (50 percent kill): 90,860 mg/m3/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
TOVEFN (6),39,2001
inhalation
rat
lethal concentration (50 percent kill): 90,860 mg/m3/4 hour Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney TOVEFN (6),39,2001
intraperitoneal
rat
lowest published lethal dose: 800 mg/kg N/R CSCIAE 61,451,1981
ocular
mammal (species unspecified)
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TOVEFN (6),39,2001
oral
guinea pig
lethal dose (50 percent kill): 2,950 mg/kg N/R TOVEFN (6),39,2001
oral
mouse
lethal dose (50 percent kill): 4,750 mg/kg N/R TOVEFN (6),39,2001
oral
rat
lethal dose (50 percent kill): 5,600 mg/kg Behavioral: Somnolence (general depressed activity) GTPZAB 31(12),53,1987
oral
rat
lethal dose (16 percent kill): 2,460 mg/kg N/R VCVGK* -,377,1984
oral
rat
lethal dose (84 percent kill): 9,300 mg/kg N/R VCVGK* -,377,1984
oral
rat
lethal dose (50 percent kill): 5,165 mg/kg N/R TOVEFN (6),39,2001
subcutaneous
mouse
lowest published lethal dose: 2 gm/kg N/R APFRAD 14,710,1956
skin
guinea pig
lethal dose (50 percent kill): >8 gm/kg N/R FCTOD7 26,379,1988
skin
mammal (species unspecified)
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TOVEFN (6),39,2001
skin
mouse
lowest published toxic dose: 100 pph/5 hour Skin: After topical application: Corrosive TOVEFN (6),39,2001
skin
rat
lowest published toxic dose: 100 pph/5 hour Skin: After topical application: Corrosive TOVEFN (6),39,2001
skin
rabbit
lethal dose (50 percent kill): 3,180 ÁL/kg Liver: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0535072


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 39 mg/m3 (10 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
CSCIAE Clinical Science. (Biochemical Society Book Depot, POB 32, Commerce Way Colchester, Essex CO2 8HP, UK) V.1-44, 1933-73; V.56- 1979-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Primary Irritant

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