CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Butyraldehyde

RTECS #: ES2275000

CAS #: 123-72-8


UPDATE: August 2007 MW: 72.12 MF: C4H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aldehyde butyrique (French)
  2. Aldeide butirrica (Italian)
  3. Butal
  4. Butaldehyde
  5. Butalyde
  6. Butanal
  7. Butanaldehyde
  8. Butyl aldehyde
  1. Butyral
  2. Butyraldehyd (German)
  3. Butyric aldehyde
  4. NCI - C56291
  5. n - Butanal (Czech)
  6. n - Butyl aldehyde
  7. n - Butyraldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,270,1986
skin
rabbit
410 mg open irritation test mild UCDS** 7/20/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage mammal (species unspecified) lymphocyte 100 mmol/L MUREAV 283,131,1992
unscheduled DNA synthesis rat liver 30 mmol/L MUREAV 323,121,1994
mutation in mammalian somatic cells hamster lung 3 mmol/L MUTAEX 4,277,1989
sister chromatid exchange hamster ovary 9 mg/L EMMUEG 10(Suppl 10),1,1987
sperm morphology intraperitoneal
mouse
30 mg/kg MUREAV 39,317,1977
sperm morphology oral
mouse
15 gm/kg/50 day MUREAV 39,317,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 5,000 mg/m3 Gastrointestinal: Changes in structure or function of salivary glands VCVGK* -,373,1984
inhalation
human
lowest published toxic concentration: 13 mg/m3 Eye: Conjunctiva irritation VCVGK* -,373,1984
inhalation
human
lowest published toxic concentration: 0.75 mg/m3 Brain and Coverings: Other degenerative changes VCVGK* -,373,1984
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 38 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse
lethal concentration (50 percent kill): 44,610 mg/m3/2 hour N/R 85GMAT -,30,1982
inhalation
mouse
lethal concentration (50 percent kill): 36,000 mg/m3/2 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVGK* -,373,1984
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R NTIS** OTS0516688
inhalation
rat
lethal concentration (50 percent kill): 6,400 ppm/4 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVGK* -,373,1984
inhalation
rat
lowest published toxic concentration: 600 ppm/10 minute Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,373,1984
inhalation
rat
lethal concentration (50 percent kill): 60,000 ppm/30 minute N/R ENTOX* -,367,2005
inhalation
rabbit
lowest published toxic concentration: 200 mg/m3/40 minute Lung, Thorax, or Respiration: Dyspnea VCVGK* -,373,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 1,140 mg/kg N/R FCTXAV 17,731,1979
intraperitoneal
rat
lethal dose (50 percent kill): 800 mg/kg N/R FCTXAV 17,731,1979
oral
rat
lethal dose (50 percent kill): 2,490 mg/kg N/R NTIS** OTS0516688
oral
rat
lethal dose (50 percent kill): 5,890 mg/kg Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVGK* -,373,1984
subcutaneous
mouse
lethal dose (50 percent kill): 2,700 mg/kg Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Hematuria
APTOA6 6,299,1950
subcutaneous
rat
lethal dose (50 percent kill): 10 gm/kg Behavioral: General anesthetic APTOA6 6,299,1950
skin
rabbit
lethal dose (50 percent kill): 3,560 ÁL/kg N/R UCDS** 7/20/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0570659
inhalation
dog
lowest published toxic concentration: 2,000 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects NTIS** OTS0538653
inhalation
guinea pig
lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570659
inhalation
mouse
lowest published toxic concentration: 6,400 ppm/6 hour/2 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0570659
inhalation
rat
lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Dyspnea

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570659
inhalation
rat
lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0538653
inhalation
rat
lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects VCVGK* -,373,1994
inhalation
rat
lowest published toxic concentration: 50 mg/m3/110 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,373,1994
inhalation
rat
lowest published toxic concentration: 0.5 mg/m3/120 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVGK* -,373,1994
inhalation
rabbit
lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0570659
inhalation
rabbit
lowest published toxic concentration: 50 mg/m3/110 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,373,1994
oral
mouse
lowest published toxic dose: 78 gm/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0516688
oral
mouse
lowest published toxic dose: 15,000 mg/kg/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach
VCVGK* -,373,1994
oral
rat
lowest published toxic dose: 39 gm/kg/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0516688
oral
rat
lowest published toxic dose: 15,000 mg/kg/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach
VCVGK* -,373,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
EVHPAZ 11,163,1975
TOXICOLOGY REVIEW
ENTOX* -,367,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 64 mg/m3 (20 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0281;
Number of Industries 3;
Total Number of Facilities 91;
Number of Occupations 9;
Total Number of Employees Exposed 1,258
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0281;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 6;
Total Number of Employees Exposed 5,392;
Total Number of Female Employees Exposed 950


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make intermediates for plasticizers, coatings, dyes and insecticides
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used to make intermediates for plasticizers, coatings, dyes and insecticides

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us