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Registry of Toxic Effects of Chemical Substances (RTECS)

tert-Butyl peroxide

RTECS #

ER2450000

CAS #

110-05-4

Updated

February 2006

Molecular Weight

146.26

Molecular Formula

C8H18O2

Synonyms

(Tributyl)peroxide
Bis(1,1-dimethylethyl)peroxide
Bis(t-butyl)peroxide
Cadox TBP
Di-tert-butyl peroxide
Di-tert-butyl peroxyde (Dutch)
Di-tert-butylperoxid (German)
DTBP
Interox DTB
Kayabutyl D
Perbutyl D
Perossido di butile terziario (Italian)
Peroxide, bis(1,1-dimethylethyl)
Peroxyde de butyle tertiaire (French)
Trigonox B

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,263,1986
eye /rabbit 200 mg/1M rinse mildZAARAM 8,25,1958
skin /rabbit 500 mgAIHAAP 19,205,1958

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 226 mg/m3/4H (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)GTPZAB 20(12),46,1976

Tumorigenic Data and References

Route/OrganismDoseEffectReference
unreported route/mouse lowest published toxic dose: 585 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
RARSAM 3,193,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >4103 ppm/4HBehavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 19,205,1958
inhalation/rat lethal concentration (50 percent kill): >4100 ppm/4HARCOC* JUN1982
intraperitoneal/mouse lethal dose (50 percent kill): 4572 mg/kgVCVGK* -,526,1994
intraperitoneal/rat lethal dose (50 percent kill): 3210 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia
AIHAAP 19,205,1958
oral/mouse lethal dose (50 percent kill): 216.4 mg/kgVCVGK* -,526,1994
oral/rat lethal dose (50 percent kill): >25 gm/kgARCOC* JUN1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 105 gm/kg/7W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 19,205,1958

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0478; Number of Industries 26; Total Number of Facilities 1178; Number of Occupations 30; Total Number of Employees Exposed 20561; Total Number of Female Employees Exposed 6371
National Occupational Hazard Survey 1974Hazard Code M0478; Number of Industries 3; Total Number of Facilities 100; Number of Occupations 5; Total Number of Employees Exposed 872

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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