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tert - Butylhydroperoxide

RTECS #: EQ4900000

CAS #: 75-91-2


UPDATE: May 2009 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethyl hydroperoxide
  2. BHP
  3. Cadox TBH
  4. Hydroperoxide, 1,1 - dimethylethyl - (9CI)
  5. Hydroperoxide, tert - butyl
  6. Hydroperoxyde de butyle tertiaire (French)
  1. Perbutyl H
  2. TBHP - 70
  3. Trigonox A - 75 (Czech)
  4. Trigonox A - W70
  5. t - Butyl hydroperoxide
  6. terc. Butylhydroperoxid (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
7 mg N/R AIHAAP 19,205,1958
eye
rabbit
100 mg/24 hour moderate 28ZPAK -,39,1972
eye
rabbit
150 mg/1 minute rinse severe ZAARAM 8,25,1958
eye
rabbit
70 L severe NTIS** OTS0543782
eye
rabbit
75% VCVGK* -,522,1994
eye
rabbit
0.2 mL VCVGK* -,522,1994
skin
rabbit
500 mg AIHAAP 19,205,1958
skin
rabbit
500 mg/24 hour severe 28ZPAK -,39,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 150 mol/L MUREAV 213,243,1989
cytogenetic analysis human lymphocyte 400 mol/L/15 minute MUTAEX 21,21,2006
cytogenetic analysis human lymphocyte 500 mol/L/30 minute MUREAV 559,97,2004
cytogenetic analysis inhalation
mouse
107 mg/m3/10 week GTPZAB 22(2),53,1978
cytogenetic analysis inhalation
rat
107 mg/m3/10 week GTPZAB 22(2),53,1978
cytogenetic analysis inhalation
rat
107.15 mg/m3/122 day VCVGK* -,521,1994
cytogenetic analysis inhalation
rat
107 g/L/122 day- intermittent TPKVAL 15,90,1979
dominant lethal test inhalation
mouse
17 mg/m3/10 week GTPZAB 22(2),53,1978
dominant lethal test intraperitoneal
mouse
1,500 mol/kg/5 day- continuous MUREAV 444,145,1999
DNA damage hamster lung 500 mol/L MUREAV 213,243,1989
DNA damage hamster ovary 100 mol/L/1 hour MUREAV 583,189,2005
DNA damage human lymphocyte 400 mol/L/15 minute MUTAEX 21,21,2006
DNA damage human liver 0.5 mol/L/20 minute MUREAV 632,1,2007
DNA damage rat other cell types 0.1 mmol/L/1 hour MUREAV 535,103,2003
DNA damage rat liver 0.5 mmol/L/1 hour MUREAV 535,103,2003
DNA damage Salmonella typhimurium 11 mmol/L EVHPAZ 88,111,1990
DNA damage Saccharomyes cerevisiae 2 mmol/L/1 hour MUREAV 539,29,2003
unscheduled DNA synthesis rat liver 1.5 mmol/L/30 minute ARTODN 79,102,2005
mutation in microorganisms Escherichia coli 78 g/plate (-enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms Escherichia coli 25 g/plate (+enzymatic activation step) MUREAV 467,41,2000
mutation in microorganisms Escherichia coli 50 g/plate/20 minute MUREAV 492,91,2001
mutation in microorganisms Escherichia coli 25 g/plate/48 hour (+/-enzymatic activation step) MUREAV 539,29,2003
mutation in microorganisms Escherichia coli 20 g/plate/48 hour MUTAEX 15,317,2000
mutation in microorganisms Escherichia coli 150 g/plate/72 hour MUREAV 564,31,2004
mutation in microorganisms Escherichia coli 225 mg/L/24 hour MUREAV 564,31,2004
mutation in microorganisms Neurospora crassa 10 mmol/L/30 minute (-enzymatic activation step) PNASA6 35,581,1949
mutation in microorganisms Salmonella typhimurium 17 g/plate (+/-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 100 g/plate/48 hour (+/-enzymatic activation step) MUREAV 539,29,2003
mutation in microorganisms Salmonella typhimurium embryo 100 g/plate/48 hour MUREAV 542,89,2003
mutation in microorganisms Salmonella typhimurium 45 g/plate/72 hour (-enzymatic activation step) MUTAEX 15,495,2000
mutation in microorganisms Salmonella typhimurium 20 g/plate/48 hour MUTAEX 15,317,2000
mutation in microorganisms Salmonella typhimurium 1 mol/plate/73 hour (+/-enzymatic activation step) MUREAV 629,122,2007
micronucleus test human lymphocyte 500 mol/L/30 minute MUREAV 559,97,2004
other mutation test systems Escherichia coli 30 mol/L MUREAV 203,81,1988
phage inhibition capacity Escherichia coli 25 mg/L VIRLAX 99,257,1979
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
500 mmol/L PNASA6 40,1037,1954
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
1,000 ppm ENMUDM 7,677,1985
sex chromosome loss and nondisjunction hamster lung 34 mol/L MUREAV 182,135,1987
specific locus test multiple
Drosophila melanogaster
1 mmol/L MUREAV 440,139,1999
sperm morphology inhalation
mouse
107 g/L/122 day- intermittent TPKVAL 15,90,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 1,059.8 mg/kg (2 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 22,479,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 350 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
mouse
lethal concentration (50 percent kill): 1,800 mg/m3/4 hour N/R VCVGK* -,520,1994
inhalation
rat
lethal concentration (50 percent kill): 500 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
rat
lethal concentration (50 percent kill): 1,800 mg/m3/4 hour N/R VCVGK* -,520,1994
inhalation
rat
lowest published toxic concentration: 600 mg/m3/4 hour Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea

Blood: Methemoglobinemia- Carboxhemoglobinemia
VCVGK* -,520,1994
inhalation
rat
lowest published toxic concentration: 180 mg/m3 Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,520,1994
inhalation
rat
lowest published toxic concentration: 260 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes TPKVAL 14,73,1975
inhalation
rat
lowest published toxic concentration: 180 mg/m3 Behavioral: Tremor TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 260 mg/m3 Behavioral: Somnolence (general depressed activity) TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 360 mg/m3 N/R TPKVAL 15,90,1979
intraperitoneal
mouse
lethal dose (50 percent kill): 2,400 g/kg N/R VCVGK* -,521,1994
intraperitoneal
mouse
lowest published toxic dose: 5,408.4 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases BPBLEO 28,531,2005
intraperitoneal
rat
lethal dose (50 percent kill): 87 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia
AIHAAP 19,205,1958
intraperitoneal
rat
lowest published toxic dose: 9.014 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 40,635,2002
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 147,271,2004
intraperitoneal
rat
lowest published toxic dose: 9.014 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 76,664,2002
intraperitoneal
rat
lowest published toxic dose: 9.014 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 79,102,2005
intraperitoneal
rat
lethal dose (50 percent kill): 87 mg/kg N/R ENTOX* -,554,2005
intraperitoneal
rat
lowest published toxic dose: 9.014 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BPBLEO 28,1639,2005
intravenous
rat
lowest published lethal dose: 20 mg/kg N/R VCVGK* -,521,1994
oral
cat
lowest published toxic dose: 500 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,521,1994
oral
mouse
lethal dose (50 percent kill): 320 mg/kg N/R VCVGK* -,521,1994
oral
mouse
lethal dose (50 percent kill): 320 mg/kg Behavioral: Irritability

Gastrointestinal: Alteration in gastric secretion

Blood: Hemorrhage
TPKVAL 15,90,1979
oral
rat
lethal dose (50 percent kill): 370 mg/kg N/R VCVGK* -,521,1994
oral
rat
lethal dose (50 percent kill): 370 mg/kg Behavioral: Irritability

Gastrointestinal: Alteration in gastric secretion

Blood: Hemorrhage
TPKVAL 15,90,1979
subcutaneous
rat
lowest published toxic dose: 800 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia VCVGK* -,521,1994
subcutaneous
rat
lowest published toxic dose: 117 mg/kg Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
FCTOD7 42,1315,2004
skin
rat
lethal dose (50 percent kill): 790 mg/kg N/R BSPII* 1/75-19B
skin
rabbit
lethal dose (50 percent kill): 460 L/kg Lung, Thorax, or Respiration: Cyanosis

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
ARCOC* JUN1982
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 15,90,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 107 mg/m3/61 day- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 15,90,1979
inhalation
guinea pig
lowest published toxic concentration: 17.3 mg/m3/61 day- intermittent Blood: Other changes TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 107 mg/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 107 mg/m3/91 day- intermittent Olfaction: Change in sensation of smell TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 107 mg/m3/30 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 17.3 mg/m3/30 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 17.3 mg/m3/61 day- intermittent Lung, Thorax, or Respiration: Respiratory depression TPKVAL 15,90,1979
inhalation
rat
lowest published toxic concentration: 17.3 mg/m3/122 day- intermittent Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Other changes
TPKVAL 15,90,1979
intraperitoneal
mouse
lowest published toxic dose: 1,059.8 mg/kg/2 week- intermittent Reproductive: Other effects on male

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
REPTED 22,479,2006
intraperitoneal
rat
lowest published toxic dose: 365 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,554,2005
TOXICOLOGY REVIEW
MUREAV 658,28,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14730;
Number of Industries 2;
Total Number of Facilities 75;
Number of Occupations 3;
Total Number of Employees Exposed 433
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14730;
Number of Industries 8;
Total Number of Facilities 266;
Number of Occupations 14;
Total Number of Employees Exposed 12,168;
Total Number of Female Employees Exposed 4,787


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARCOC* ARCO Chemical Company Report. (3801 West Chester Pike, Newton Square, PA 19073)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
BSPII* SPI Bulletin. (Soc. of the Plastics Industry, 250 Park Ave., New York, NY 10017)
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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