CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Butylamine

RTECS #: EO2975000

CAS #: 109-73-9


UPDATE: May 2009 MW: 73.16 MF: C4H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Amino - butaan (Dutch)
  2. 1 - Aminobutan (German)
  3. 1 - Aminobutane
  4. 1 - Butanamine
  5. Butylamine (OSHA)
  6. Mono - n - butylamine
  7. Monobutilamina (Romanian)
  1. Monobutylamine
  2. Norvalamine
  3. n - Butilamina (Italian)
  4. n - Butylamin (German)
  5. n - Butylamine
  6. n - Butylamine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
250 g/24 hour severe 85JCAE -,431,1986
skin
rabbit
10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit
500 mg open irritation test severe UCDS** 7/19/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
110 mg/kg ZKKOBW 86,47,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2.4 gm/kg (1-6 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities
FCTOD7 40,1833,2002
oral
rat
lowest published toxic dose: 6 gm/kg (1-6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
FCTOD7 40,1833,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 800 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
BCPCA6 2,168,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 0.5 gm/m3 Behavioral: Alteration of classical conditioning TPKVAL 7,56,1965
inhalation
human
lowest published toxic concentration: 0.1 gm/m3 Gastrointestinal: Other changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,56,1965
inhalation
mammal (species unspecified)
lethal concentration : 8 gm/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction
TPKVAL 7,56,1965
inhalation
mouse
lethal concentration (50 percent kill): 800 mg/m3/2 hour N/R 85GMAT -,28,1982
inhalation
mouse
lethal concentration (50 percent kill): 800 mg/m3/4 hour N/R ENTOX* -,360,2005
inhalation
rat
lowest published lethal concentration: 4,000 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse
lethal dose (50 percent kill): 629 mg/kg N/R JPETAB 88,82,1946
intravenous
mouse
lethal dose (50 percent kill): 198 mg/kg N/R JPETAB 88,82,1946
oral
guinea pig
lethal dose (50 percent kill): 430 mg/kg N/R GISAAA 40(11),21,1975
oral
mouse
lethal dose (50 percent kill): 430 mg/kg N/R GISAAA 40(11),21,1975
oral
rat
lethal dose (50 percent kill): 366 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TXAPA9 63,150,1982
oral
rat
lethal dose (50 percent kill): 366 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
ENTOX* -,360,2005
parenteral
rat
lowest published lethal dose: 600 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
JPETAB 20,435,1923
skin
guinea pig
lethal dose (50 percent kill): 500 L/kg N/R JIHTAB 26,269,1944
skin
rabbit
lethal dose (50 percent kill): 850 L/kg N/R UCDS** 7/19/1965
skin
rabbit
lethal dose (50 percent kill): 850 mg/kg N/R ENTOX* -,360,2005
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 590 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 17 ppm/6 hour/14 day- intermittent Olfaction: Other olfaction effects FCTOD7 40,1833,2002
intramuscular
rat
lowest published toxic dose: 6 gm/kg/6 day- intermittent Behavioral: Food intake (animal) FCTOD7 40,1833,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 5 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHREAY 9,389,1931
TOXICOLOGY REVIEW
ENTOX* -,360,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (15 mg/m3) (skin) DTLVS* 3,32,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 5 ppm (15 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (15 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 5 ppm (15 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 5 ppm (15 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 15 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 5 ppm (15 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA ceiling concentration 5 ppm (15 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO peak 5 ppm (15 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 15 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN ceiling concentration 5 ppm (15 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (6.1 mg/m3);
KZG- week 4 ppm (12.2 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 5 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 5 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYLAMINE-air ceiling concentration 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14440;
Number of Industries 4;
Total Number of Facilities 97;
Number of Occupations 9;
Total Number of Employees Exposed 1,168
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14440;
Number of Industries 2;
Total Number of Facilities 20;
Number of Occupations 1;
Total Number of Employees Exposed 414;
Total Number of Female Employees Exposed 85


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: n-Butylamine, 2012


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us