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Registry of Toxic Effects of Chemical Substances (RTECS)

3-Buten-2-one

RTECS #

EM9800000

CAS #

78-94-4

Updated

September 201

Molecular Weight

70.10

Molecular Formula

C4H6O

Synonyms

3-Butene-2-one
Acetone, methylene-
Acetyl ethylene
Butenone
delta(sup 3)-2-Butenone
gamma-Oxo-alpha-butylene
Ketone, methyl vinyl
Methyl vinyl ketone
Methylene acetone
Methylvinyl ketone
Methyl-vinyl-cetone (French)
Methylvinylketon (German)
MVK
Vinyl methyl ketone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /mouse 1% severeVCVGK* -,434,1994
skin /mouse 0.1% mildVCVGK* -,434,1994
skin /rat 0.1% mildVCVGK* -,434,1994
skin /rat 1% severeVCVGK* -,434,1994

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium250 µmol/L (+enzymatic activation step)MUREAV 93,305,1982
mutation in microorganisms/Escherichia coli125 µg/plate (+enzymatic activation step)MUREAV 412,17,1998
other mutation test systems/Escherichia coli100 nmol/tubeCRTOEC 4,50,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 8 mg/m3/2H85GMAT -,88,1982
inhalation/mouse lethal concentration (50 percent kill): 16 mg/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes
VCVGK* -,433,1994
inhalation/rat lethal concentration (50 percent kill): 14 mg/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes
VCVGK* -,433,1994
inhalation/rat lethal concentration (50 percent kill): 7 mg/m3/4H85GMAT -,88,1982
intraperitoneal/guinea pig lowest published lethal dose: 15 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0555304
intraperitoneal/mouse lethal dose (50 percent kill): 76 mg/kgZolH## 23OCT1975
intraperitoneal/rat lowest published lethal dose: 15 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
NTIS** OTS0555304
oral/guinea pig lowest published lethal dose: 15 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0555304
oral/mouse lethal dose (50 percent kill): 23300 µg/kgGISAAA 58(10),4,1993
oral/mouse lethal dose (50 percent kill): 33.5 mg/kgGastrointestinal: Necrotic changesVCVGK* -,433,1994
oral/rat lethal dose (50 percent kill): 31 mg/kgGastrointestinal: Necrotic changesVCVGK* -,433,1994
oral/rat lethal dose (50 percent kill): 23100 µg/kgGISAAA 58(10),4,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 7800 ppb/6H/9D- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555304
inhalation/mouse lowest published toxic concentration: 4 ppm/24H/intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOSCF2 58,182,2000
inhalation/mouse lowest published toxic concentration: 8 ppm/72H/intermittentLung, Thorax, or Respiration: Other changesTOSCF2 58,182,2000
inhalation/mouse lowest published toxic concentration: 8 ppm/60H/intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOSCF2 58,182,2000
inhalation/mouse lowest published toxic concentration: 2 ppm/72H/intermittentOlfaction: Other olfaction effectsTOSCF2 58,182,2000
inhalation/rabbit lowest published toxic concentration: 4 mg/m3/4H/75D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,434,1994
inhalation/rabbit lowest published toxic concentration: 7800 ppb/6H/9D- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0555304
inhalation/rat lowest published toxic concentration: 3900 ppb/6H/9D- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555304
inhalation/rat lowest published toxic concentration: 1.8 mg/m3/6H/137D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired
VCVGK* -,434,1994
inhalation/rat lowest published toxic concentration: 0.9 mg/m3/6H/137D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainVCVGK* -,434,1994
inhalation/rat lowest published toxic concentration: 2 ppm/24H/intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOSCF2 58,182,2000
inhalation/rat lowest published toxic concentration: 2 ppm/72H/intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,182,2000
inhalation/rat lowest published toxic concentration: 2 ppm/72H/intermittentOlfaction: Other olfaction effectsTOSCF2 58,182,2000
inhalation/rat lowest published toxic concentration: 4 ppm/72H/intermittentLung, Thorax, or Respiration: Other changesTOSCF2 58,182,2000
inhalation/rat lowest published toxic concentration: 2 ppm/390H/intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
TOSCF2 58,182,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.2 ppm (skin, sen)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.2 ppm (0.58 mg/m3), Skin, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 ppm (0.6 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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