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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Buten-3-ol, 3-methyl-

RTECS #

EM9472000

CAS #

115-18-4

Updated

July 2011

Molecular Weight

86.15

Molecular Formula

C5H10O

Synonyms

1,1-Dimethylallyl alcohol
2-Methyl-3-buten-2-ol
3-Butyn-2-ol, 2-methyl- (8CI,9CI)
3-Methyl-1-buten-3-ol
3-Methyl-buten-(1)-ol-(3) (German)
alpha,alpha-Dimethylallyl alcohol
Dimethylvinylcarbinol
Dimethylvinylmethanol
Methylbutenol
Vinyldimethylcarbinol

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2800 mg/kg (14D prior to copulation)Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
FCTOD7 48(Suppl 3),S97,2010

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 2300 mg/m3VCVGK* -,124,1984
inhalation/rat lethal concentration (50 percent kill): >21200 mg/m3/4HBehavioral: AtaxiaFCTOD7 48(Suppl 3),S97,2010
intraperitoneal/mouse lethal dose (50 percent kill): 800 mg/kgIJSBDB 14,449,1976
intraperitoneal/rat lethal dose (50 percent kill): 1.3 gm/kgFCTOD7 48(Suppl 3),S97,2010
oral/rat lethal dose (50 percent kill): 1074 mg/kgVCVGK* -,124,1984
skin/rabbit lethal dose (50 percent kill): >2 gm/kgFCTOD7 48(Suppl 3),S97,2010
subcutaneous/mouse lethal dose (50 percent kill): 1680 mg/kgARZNAD 5,161,1955
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 435 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 3000 mg/m3/4H/2W- intermittentBrain and Coverings: Other degenerative changes

Blood: Changes in cell count (unspecified)
VCVGK* -,124,1994
inhalation/rat lowest published toxic concentration: 15 mg/m3/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Immunological Including Allergic: Decreased immune response
VCVGK* -,124,1994
oral/rat lowest published toxic dose: 182 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,124,1994
oral/rat lowest published toxic dose: 21000 mg/kg/4W- intermittentNutritional and Gross Metabolic: Changes in: Cl

Nutritional and Gross Metabolic: Changes in: K

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48(Suppl 3),S97,2010
oral/rat lowest published toxic dose: 5600 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 48(Suppl 3),S97,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.6 ppm (2 mg/m3);KZW 1.2 ppm (4 mg/m3), 2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7945; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 5; Total Number of Employees Exposed 1557; Total Number of Female Employees Exposed 276

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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