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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Butene, 2,3,4-trichloro-

RTECS #

EM9046000

CAS #

2431-50-7

Updated

July 2013

Molecular Weight

159.44

Molecular Formula

C4H5Cl3

Synonyms

2,3,4-Trichlorobutene-1

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 ppm/6H/85W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
NTIS** OTS0555038

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 100 mg/m3VCVGH* -,492,1990
inhalation/rat lethal concentration (50 percent kill): 625 mg/m3VCVGH* -,492,1990
oral/mammal (species unspecified) lethal dose (50 percent kill): 345 mg/kgVCVGH* -,492,1990
oral/rat lethal dose (50 percent kill): 341 mg/kgGISAAA 46(1),92,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2500 ppb/6H/13W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0546198
inhalation/rat lowest published toxic concentration: 2500 ppb/6H/13W- intermittentBehavioral: Excitement

Liver: Liver function tests impaired

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0546540

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.005 ppm (0.035 mg/m3);KZW 0.02 ppm (0.14 mg/m3), 2007
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.005 ppm (0.035 mg/m3), carc 2, skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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