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1,4 - Butanediol

RTECS #: EK0525000

CAS #: 110-63-4


UPDATE: August 2008 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,4 - Butylene glycol
  2. 1,4 - Dihydroxybutane
  3. 1,4 - Tetramethylene glycol
  4. Agrisynth B1D
  5. Butane - 1,4 - diol
  1. Butanediol
  2. DIOL 14B
  3. Sucol B
  4. Tetramethylene 1,4 - diol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 15 gm/m3/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 3,379,1991
intraperitoneal
mouse
lethal dose (50 percent kill): 1,650 mg/kg N/R TXAPA9 49,385,1979
intraperitoneal
mouse
lowest published lethal dose: 500 mg/kg N/R VCVGK* -,152,1984
intraperitoneal
mouse
lowest published toxic dose: 177.6 mg/kg Behavioral: Change in motor activity (specific assay) JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 209.3 mg/kg Behavioral: Rigidity (includes catalepsy) JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 73.3 mg/kg Behavioral: Ataxia JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 501.1 mg/kg Behavioral: Altered sleep time (including change in righting reflex) JPETAB 313,1314,2005
intraperitoneal
mouse
lowest published toxic dose: 163.9 mg/kg Behavioral: Muscle weakness JTCTDW 41,692,2003
intraperitoneal
rat
lethal dose (50 percent kill): 1,070 mg/kg N/R JPPMAB 26,597,1974
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg Behavioral: Ataxia VCVGK* -,152,1984
intraperitoneal
rat
lowest published toxic dose: 178 mg/kg Behavioral: Alteration of operant conditioning EJPHAZ 484,259,2004
intraperitoneal
rat
lowest published toxic dose: 32 mg/kg Behavioral: Change in psychophysiological tests JPETAB 305,668,2003
ocular
mouse
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 7,5,1965
oral
guinea pig
lethal dose (50 percent kill): 1,200 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
guinea pig
lethal dose (50 percent kill): 1,200 mg/kg N/R VCVGK* -,152,1984
oral
man
lowest published toxic dose: 42.8 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
CTOXAO 40,77,2002
oral
mouse
lethal dose (50 percent kill): 2,062 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
mouse
lethal dose (50 percent kill): 2,062 mg/kg N/R VCVGK* -,152,1984
oral
mouse
lethal dose : 750 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 7,5,1965
oral
mouse
lowest published toxic dose: 250 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
TPKVAL 7,5,1965
oral
rat
lethal dose (50 percent kill): 1,525 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
rat
lethal dose (50 percent kill): 1,525 mg/kg N/R VCVGK* -,152,1984
oral
rat
lowest published lethal dose: 1,000 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
TPKVAL 7,5,1965
oral
rat
lethal dose : 2,500 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 7,5,1965
oral
rat
lowest published toxic dose: 500 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Ataxia

Vascular: Other changes
TPKVAL 7,5,1965
oral
rabbit
lethal dose (50 percent kill): 2,531 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral
rabbit
lethal dose (50 percent kill): 2,531 mg/kg N/R VCVGK* -,152,1984
rectal
man
lowest published lethal dose: 429 mg/kg N/R PHARAT 3,110,1948
skin
mouse
lowest published toxic dose: 100 pph/2 hour Skin: After topical application: Primary irritation TPKVAL 7,5,1965
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 7,5,1965
unreported route
woman
lowest published lethal dose: 300 mg/kg Behavioral: Altered sleep time (including change in righting reflex) PHARAT 3,110,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1,500 mg/m3/4 hour/122 day- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) VCVGK* -,152,1994
inhalation
mouse
lowest published toxic concentration: 0.4 gm/m3/30 day- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,5,1965
inhalation
rat
lowest published toxic concentration: 5,200 mg/m3/6 hour/2 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 3,379,1991
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/30 day- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,5,1965
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/122 day- intermittent Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 7,5,1965
inhalation
rat
lowest published toxic concentration: 1.75 gm/m3/3 week- intermittent Behavioral: Somnolence (general depressed activity) TPKVAL 7,5,1965
intraperitoneal
rat
lowest published toxic dose: 36,960 mg/kg/6 week- intermittent Behavioral: Tolerance

Behavioral: Alteration of operant conditioning
EJPHAZ 483,259,2004
oral
rat
lowest published toxic dose: 5,460 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other carbohydrates
GISAAA 33(1),37,1968
oral
rat
lowest published toxic dose: 14 gm/kg/28 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
PJOMEY 3,421,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JJATDK 26,72,2006
TOXICOLOGY REVIEW
REPTED 25,192,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 200 mg/m3 (50 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0752;
Number of Industries 7;
Total Number of Facilities 226;
Number of Occupations 22;
Total Number of Employees Exposed 16,785
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0752;
Number of Industries 21;
Total Number of Facilities 759;
Number of Occupations 25;
Total Number of Employees Exposed 16,811;
Total Number of Female Employees Exposed 3,870


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of polyurethanes, plasticizers, elastomers and surface coatings
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-54, October 2000


REFERENCES:

CODEN
REFERENCE

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-
PJOMEY Polish Journal of Occupational Medicine. (Polish Journal of Occupational Medicine, P.O. Box 199, 90-950 Lodz, Poland) V.1-3; 1988-90. Discontinued.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in production of polyurethanes, plasticizers, elastomers and surface coatings

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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