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Registry of Toxic Effects of Chemical Substances (RTECS)

1,4-Butanediol

RTECS #

EK0525000

CAS #

110-63-4

Updated

April 2012

Molecular Weight

90.14

Molecular Formula

C4H10O2

Synonyms

1,4-Butylene glycol
1,4-Dihydroxybutane
1,4-Tetramethylene glycol
Agrisynth B1D
Butane-1,4-diol
Butanediol
DIOL 14B
Sucol B
Tetramethylene 1,4-diol

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 15 gm/m3/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 3,379,1991
intraperitoneal/mouse lethal dose (50 percent kill): 1650 mg/kgTXAPA9 49,385,1979
intraperitoneal/mouse lowest published lethal dose: 500 mg/kgVCVGK* -,152,1984
intraperitoneal/mouse lowest published toxic dose: 177.6 mg/kgBehavioral: Change in motor activity (specific assay)JPETAB 313,1314,2005
intraperitoneal/mouse lowest published toxic dose: 209.3 mg/kgBehavioral: Rigidity (includes catalepsy)JPETAB 313,1314,2005
intraperitoneal/mouse lowest published toxic dose: 73.3 mg/kgBehavioral: AtaxiaJPETAB 313,1314,2005
intraperitoneal/mouse lowest published toxic dose: 501.1 mg/kgBehavioral: Altered sleep time (including change in righting reflex)JPETAB 313,1314,2005
intraperitoneal/mouse lowest published toxic dose: 163.9 mg/kgBehavioral: Muscle weaknessJTCTDW 41,692,2003
intraperitoneal/rat lowest published toxic dose: 250 mg/kgBehavioral: AtaxiaVCVGK* -,152,1984
intraperitoneal/rat lowest published toxic dose: 178 mg/kgBehavioral: Alteration of operant conditioningEJPHAZ 484,259,2004
intraperitoneal/rat lowest published toxic dose: 32 mg/kgBehavioral: Change in psychophysiological testsJPETAB 305,668,2003
intraperitoneal/rat lethal dose (50 percent kill): 1070 mg/kgJPPMAB 26,597,1974
ocular/mouse lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 7,5,1965
oral/guinea pig lethal dose (50 percent kill): 1200 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/guinea pig lethal dose (50 percent kill): 1200 mg/kgVCVGK* -,152,1984
oral/human lowest published toxic dose: 10 mg/kgBehavioral: SleepJTCTDW 46,400,2008
oral/man lowest published toxic dose: 42.8 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
JTCTDW 40,77,2002
oral/monkey lowest published toxic dose: 56 mg/kgBehavioral: Food intake (animal)

Behavioral: Alteration of classical conditioning
PSCHDL 204,465,2009
oral/monkey lowest published toxic dose: 180 mg/kgBehavioral: Tremor

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting
PSCHDL 204,465,2009
oral/monkey lowest published toxic dose: 240 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
PSCHDL 204,465,2009
oral/mouse lowest published toxic dose: 250 mg/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
TPKVAL 7,5,1965
oral/mouse lowest published lethal dose: 750 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 7,5,1965
oral/mouse lethal dose (50 percent kill): 2062 mg/kgVCVGK* -,152,1984
oral/mouse lethal dose (50 percent kill): 2062 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/rabbit lethal dose (50 percent kill): 2531 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/rabbit lethal dose (50 percent kill): 2531 mg/kgVCVGK* -,152,1984
oral/rat lethal dose (50 percent kill): 1525 mg/kgVCVGK* -,152,1984
oral/rat lethal dose (50 percent kill): 1525 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes
HYSAAV 33(1-3),41,1968
oral/rat lowest published lethal dose: 2500 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 7,5,1965
oral/rat lowest published lethal dose: 1000 mg/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
TPKVAL 7,5,1965
oral/rat lowest published toxic dose: 500 mg/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Ataxia

Vascular: Other changes
TPKVAL 7,5,1965
rectal/man lowest published lethal dose: 429 mg/kgPHARAT 3,110,1948
unreported route/woman lowest published lethal dose: 300 mg/kgBehavioral: Altered sleep time (including change in righting reflex)PHARAT 3,110,1948

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 1500 mg/m3/4H/122D- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)VCVGK* -,152,1994
inhalation/mouse lowest published toxic concentration: 0.004 gm/m3/30D- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,5,1965
inhalation/rat lowest published toxic concentration: 0.4 gm/m3/122D- intermittentVascular: Structural changes in vessels

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 7,5,1965
inhalation/rat lowest published toxic concentration: 1.75 gm/m3/3W- intermittentBehavioral: Somnolence (general depressed activity)TPKVAL 7,5,1965
inhalation/rat lowest published toxic concentration: 5200 mg/m3/6H/2W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 3,379,1991
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/30D- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,5,1965
intraperitoneal/rat lowest published toxic dose: 36960 mg/kg/6W- intermittentBehavioral: Tolerance

Behavioral: Alteration of operant conditioning
EJPHAZ 483,259,2004
oral/rat lowest published toxic dose: 5460 mg/kg/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other carbohydrates
GISAAA 33(1),37,1968
oral/rat lowest published toxic dose: 14 gm/kg/28D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
PJOMEY 3,421,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJJATDK 26,72,2006
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (200 mg/m3);KZW 200 ppm (800 mg/m3), 2007
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0752; Number of Industries 21; Total Number of Facilities 759; Number of Occupations 25; Total Number of Employees Exposed 16811; Total Number of Female Employees Exposed 3870
National Occupational Hazard Survey 1974Hazard Code M0752; Number of Industries 7; Total Number of Facilities 226; Number of Occupations 22; Total Number of Employees Exposed 16785

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-54, October 2000
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