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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Butanediol

RTECS #

EK0440000

CAS #

107-88-0

Updated

July 2011

Molecular Weight

90.14

Molecular Formula

C4H10O2

Synonyms

1,3-Butandiol (German)
1,3-Butylene glycol
1,3-Butylenglykol (German)
1,3-Dihydroxybutane
beta-Butylene glycol
Butane-1,3-diol
Methyltrimethylene glycol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
eye /rabbit 500 mg/24H mild85JCAE -,207,1986
skin /rabbit 500 mg/24H mild85JCAE -,207,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 42360 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JACTDZ 5(4),189,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.05 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intraperitoneal/mouse lethal dose (50 percent kill): 10276 mg/kgTXAPA9 49,385,1979
intraperitoneal/rat lowest published toxic dose: 5890 mg/kgBehavioral: AtaxiaVCVGK* -,151,1984
oral/guinea pig lethal dose (50 percent kill): 11000 mg/kgVCVGK* -,151,1984
oral/guinea pig lethal dose (50 percent kill): 11 gm/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 12980 mg/kgHPV009 -,-,2002
oral/rat lethal dose (50 percent kill): 18610 mg/kgHPV009 -,-,2002
skin/rabbit lethal dose (50 percent kill): >20 gm/kgNPIRI* 1,14,1974
subcutaneous/rat lethal dose (50 percent kill): 20000 mg/kgVCVGK* -,151,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 819000 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV009 -,-,2002
oral/mammal (species unspecified) lowest published toxic dose: 12000 mg/kg/12D- intermittentBehavioral: Abuse

Behavioral: Alteration of classical conditioning

Endocrine: Change in LH
VCVGK* -,152,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 4(5),223,1985
TOXICOLOGY REVIEWDERCL* 27,289,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,298,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83068; Number of Industries 13; Total Number of Facilities 1070; Number of Occupations 17; Total Number of Employees Exposed 19336; Total Number of Female Employees Exposed 5266
National Occupational Hazard Survey 1974Hazard Code 83068; Number of Industries 13; Total Number of Facilities 1532; Number of Occupations 22; Total Number of Employees Exposed 36963

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523
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