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Registry of Toxic Effects of Chemical Substances (RTECS)

Butane, 1,1'-oxybis-

RTECS #

EK5425000

CAS #

142-96-1

Updated

August 2007

Molecular Weight

130.26

Molecular Formula

C8H18O

Synonyms

1,1'-Oxybis(butane)
1-Butoxybutane
Butyl ether
Dibutyl ether
Dibutyl oxide
Di-n-butyl ether
Ether butylique (French)
n-Butyl ether
n-Dibutyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 200 ppm/15MJIHTAB 28,262,1946
skin /rabbit 380 mg open irritation test mildUCDS** 7/8/1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 200 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation
JIHTAB 28,262,1946
inhalation/human lowest published toxic concentration: 1000 mg/m3/3MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,269,1994
inhalation/mouse lowest published toxic concentration: 10000 mg/m3/30MBehavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation/mouse lowest published toxic concentration: 10000 mg/m3/75MBehavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation/mouse Lowest published lethal concentration: 60000 mg/m3/2HLung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation/mouse lethal concentration (50 percent kill): 169 gm/m3/15MBehavioral: General anestheticANESAV 11,455,1950
inhalation/rat Lowest published lethal concentration: 20200 mg/m3/4HLung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HAMIHBC 10,61,1954
inhalation/rat lethal concentration (50 percent kill): 4000 ppm/4HENTOX* -,358,2005
intravenous/mouse lowest published lethal dose: 258 mg/kgBehavioral: Altered sleep time (including change in righting reflex)APTOA6 37,56,1975
oral/mouse lethal dose (50 percent kill): 567 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
oral/mouse lowest published toxic dose: 455 mg/kgBehavioral: Irritability

Liver: Fatty liver degeneration
VCVGK* -,269,1994
oral/rat lethal dose (50 percent kill): 3200 mg/kgENTOX* -,358,2005
skin/rabbit lethal dose (50 percent kill): 10 mL/kgVCVGK* -,269,1994
skin/rabbit lethal dose (50 percent kill): 10000 mg/kgENTOX* -,358,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 0.4 gm/kg/4W- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 214,99,2005
oral/rat lowest published toxic dose: 4 gm/kg/4W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 214,99,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,358,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 20 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84736; Number of Industries 4; Total Number of Facilities 468; Number of Occupations 18; Total Number of Employees Exposed 6292; Total Number of Female Employees Exposed 235
National Occupational Hazard Survey 1974Hazard Code 84736; Number of Industries 3; Total Number of Facilities 97; Number of Occupations 5; Total Number of Employees Exposed 1004

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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