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Butane, 1,1' - oxybis -

RTECS #: EK5425000

CAS #: 142-96-1


UPDATE: August 2007 MW: 130.26 MF: C8H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1' - Oxybis (butane)
  2. 1 - Butoxybutane
  3. Butyl ether
  4. Di - n - butyl ether
  5. Dibutyl ether
  1. Dibutyl oxide
  2. Ether butylique (French)
  3. n - Butyl ether
  4. n - Dibutyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
200 ppm/15 minute N/R JIHTAB 28,262,1946
skin
rabbit
380 mg open irritation test mild UCDS** 7/8/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 200 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation
JIHTAB 28,262,1946
inhalation
human
lowest published toxic concentration: 1,000 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,269,1994
inhalation
mouse
lethal concentration (50 percent kill): 169 gm/m3/15 minute Behavioral: General anesthetic ANESAV 11,455,1950
inhalation
mouse
lowest published lethal concentration: 60,000 mg/m3/2 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation
mouse
lowest published toxic concentration: 10,000 mg/m3/30 minute Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation
mouse
lowest published toxic concentration: 10,000 mg/m3/75 minute Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation
rat
lowest published lethal concentration: 4,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat
lowest published lethal concentration: 20,200 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
inhalation
rat
lethal concentration (50 percent kill): 4,000 ppm/4 hour N/R ENTOX* -,358,2005
intravenous
mouse
lowest published lethal dose: 258 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975
oral
mouse
lethal dose (50 percent kill): 567 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
VCVGK* -,269,1994
oral
mouse
lowest published toxic dose: 455 mg/kg Behavioral: Irritability

Liver: Fatty liver degeneration
VCVGK* -,269,1994
oral
rat
lethal dose (50 percent kill): 3,200 mg/kg N/R ENTOX* -,358,2005
skin
rabbit
lethal dose (50 percent kill): 10 mL/kg N/R VCVGK* -,269,1994
skin
rabbit
lethal dose (50 percent kill): 10,000 mg/kg N/R ENTOX* -,358,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 0.4 gm/kg/4 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 214,99,2005
oral
rat
lowest published toxic dose: 4 gm/kg/4 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 214,99,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,358,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84736;
Number of Industries 3;
Total Number of Facilities 97;
Number of Occupations 5;
Total Number of Employees Exposed 1,004
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84736;
Number of Industries 4;
Total Number of Facilities 468;
Number of Occupations 18;
Total Number of Employees Exposed 6,292;
Total Number of Female Employees Exposed 235


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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