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Registry of Toxic Effects of Chemical Substances (RTECS)

Butane, 2-methyl-

RTECS #

EK4430000

CAS #

78-78-4; 68923-44-4; 92046-46-3

Updated

September 201

Molecular Weight

72.17

Molecular Formula

C5H12

Synonyms

1,1,2-Trimethylethane
2-Methylbutane
Ethyldimethylmethane
Isoamylhydride
Isopentane
Isopentane (ACGIH)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 419 gm/m3/2HBehavioral: ExcitementJPETAB 58,74,1936
inhalation/mouse lethal concentration (50 percent kill): 150000 mg/m3/2HVCVGH* -,28,1990
inhalation/rat lowest published toxic concentration: 270000 mg/m3/2HBehavioral: General anestheticVCVGH* -,28,1990
inhalation/rat lethal concentration (50 percent kill): 280000 mg/m3/4HVCVGH* -,28,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 10 gm/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 1(3),67,1985

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 600 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 600 ppm (1800 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 750 ppm (2250 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 500 ppm (1500 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 3000 mg/m3 (1000 ppm), FEB2006
Occupational Exposure Limit-GERMANYMAK 1000 ppm (3000 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 500 ppm (1500 mg/m3), NOV2011
Occupational Exposure Limit-PERUtime-weighted average 600 ppm (1771 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 600 ppm (1800 mg/m3);short term exposure limit 750 ppm (2000 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 600 ppm (1800 mg/m3), KZG-week 1200 ppm (3600 mg/m3), JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 600 ppm (1800 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 54246; Number of Industries 5; Total Number of Facilities 132; Number of Occupations 13; Total Number of Employees Exposed 6605; Total Number of Female Employees Exposed 1247
National Occupational Hazard Survey 1974Hazard Code 54246; Number of Industries 6; Total Number of Facilities 197; Number of Occupations 9; Total Number of Employees Exposed 21748

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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