RTECS:EK4430000 The Registry of Toxic Effects of Chemical Substances

Butane, 2 - methyl -

RTECS #: EK4430000

CAS #: 78-78-4

UPDATE: February 2009 MW: 72.17 MF: C₅H₁₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,1,2 - Trimethylethane

2 - Methylbutane

Ethyldimethylmethane

Isoamylhydride

Isopentane

Isopentane (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published lethal concentration: 419 gm/m³/2 hour Behavioral: Excitement JPETAB 58,74,1936
inhalation
mouse lethal concentration (50 percent kill): 150,000 mg/m³/2 hour N/R VCVGH* -,28,1990
inhalation
rat lowest published toxic concentration: 270,000 mg/m³/2 hour Behavioral: General anesthetic VCVGH* -,28,1990
inhalation
rat lethal concentration (50 percent kill): 280,000 mg/m³/4 hour N/R VCVGH* -,28,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 10 gm/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TIHEEC 1(3),67,1985

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 600 ppm DTLVS* TLV/BEI,2007

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 600 ppm (1800 mg/m³), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 750 ppm (2250 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (1500 mg/m³), OCT 2002
Occupational Exposure Limit - EC time-weighted average 3000 mg/m³ (1000 ppm), FEB 2006
Occupational Exposure Limit - GERMANY MAK 3000 mg/m³ (1000 mL/m³), 2005
Occupational Exposure Limit - SWEDEN time-weighted average 600 ppm (1800 mg/m³);
short term exposure limit 750 ppm (2000 mg/m³), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 600 ppm (1800 mg/m³),KZG- week 1200 ppm (3600 mg/m³), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 600 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 600 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54246;
Number of Industries 6;
Total Number of Facilities 197;
Number of Occupations 9;
Total Number of Employees Exposed 21,748
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54246;
Number of Industries 5;
Total Number of Facilities 132;
Number of Occupations 13;
Total Number of Employees Exposed 6,605;
Total Number of Female Employees Exposed 1,247

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as expanding agent in POLYSTYRENE foam beads, process solvents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as expanding agent in POLYSTYRENE foam beads, process solvents

ALT CAS #: 68923-44-4
ALT CAS #: 92046-46-3
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SYNONYMS:
1,1,2 - Trimethylethane 2 - Methylbutane Ethyldimethylmethane	Isoamylhydride Isopentane Isopentane (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lowest published lethal concentration: 419 gm/m³/2 hour	Behavioral: Excitement	JPETAB 58,74,1936
inhalation mouse	lethal concentration (50 percent kill): 150,000 mg/m³/2 hour	N/R	VCVGH* -,28,1990
inhalation rat	lowest published toxic concentration: 270,000 mg/m³/2 hour	Behavioral: General anesthetic	VCVGH* -,28,1990
inhalation rat	lethal concentration (50 percent kill): 280,000 mg/m³/4 hour	N/R	VCVGH* -,28,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 10 gm/kg/4 week- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TIHEEC 1(3),67,1985

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 600 ppm	DTLVS* TLV/BEI,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - BELGIUM	time-weighted average 600 ppm (1800 mg/m³), MAR2002
Occupational Exposure Limit - BELGIUM	short term exposure limit 750 ppm (2250 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK	time-weighted average 500 ppm (1500 mg/m³), OCT 2002
Occupational Exposure Limit - EC	time-weighted average 3000 mg/m³ (1000 ppm), FEB 2006
Occupational Exposure Limit - GERMANY	MAK 3000 mg/m³ (1000 mL/m³), 2005
Occupational Exposure Limit - SWEDEN	time-weighted average 600 ppm (1800 mg/m³); short term exposure limit 750 ppm (2000 mg/m³), JUN2005
Occupational Exposure Limit - SWITZERLAND	MAK- week 600 ppm (1800 mg/m³),KZG- week 1200 ppm (3600 mg/m³), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 600 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 600 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 54246; Number of Industries 6; Total Number of Facilities 197; Number of Occupations 9; Total Number of Employees Exposed 21,748
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 54246; Number of Industries 5; Total Number of Facilities 132; Number of Occupations 13; Total Number of Employees Exposed 6,605; Total Number of Female Employees Exposed 1,247

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as expanding agent in POLYSTYRENE foam beads, process solvents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TIHEEC	Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH*	"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.