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Registry of Toxic Effects of Chemical Substances (RTECS)

Butane, 2-methoxy-2-methyl-

RTECS #

EK4421000

CAS #

994-05-8

Updated

September 201

Molecular Weight

102.20

Molecular Formula

C6H14O

Synonyms

1,1-Dimethylpropyl methyl ether
2-Methoxy-2-methylbutane
Ether, methyl tert-pentyl (6CI,7CI,8CI)
Methyl 1,1-dimethylpropyl ether
Methyl tert-amyl ether
Methyl tert-pentyl ether
TAME
TAME (ether)
tert-Amyl methyl ether
tert-Pentyl methyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H severeNTIS** OTS0557627
skin /rabbit 500 µL/4H severeNTIS** OTS0557664

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster313000 µg/L/4H (+enzymatic activation step)HPV156 -,-,2007
Cytogenetic Analysisovary/hamster2500000 µg/L/12H (-enzymatic activation step)HPV156 -,-,2007

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 3500 ppm/6H (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0558879
inhalation/mouse 3500 ppm/6H (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** OTS0558880
inhalation/mouse 3500 ppm (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
JAPTO* 23,387,2003
inhalation/mouse 1500 ppm (6-16D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAPTO* 23,387,2003
inhalation/rat 3500 ppm (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JAPTO* 23,387,2003
inhalation/rat 1500 ppm (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV156 -,-,2007
inhalation/rat 3500 ppm (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV156 -,-,2007
inhalation/mouse 1500 ppm (6-16D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV156 -,-,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 27400 mg/m3Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
inhalation/mouse Lowest published lethal concentration: 3500 ppm/6HEye: Other eye effects

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
JAPTO* 23,387,2003
inhalation/mouse Lowest published lethal concentration: 3500 ppm/6HBehavioral: Sleep

Blood: Hemorrhage
JAPTO* 23,387,2003
inhalation/mouse lowest published toxic concentration: 100 ppm/6HBehavioral: Change in motor activity (specific assay)JAPTO* 23,419,2003
inhalation/mouse Lowest published lethal concentration: 3500 ppm/6HHPV156 -,-,2007
inhalation/rat lethal concentration (50 percent kill): >5400 mg/m3/4HHPV156 -,-,2007
inhalation/rat lowest published toxic concentration: 3500 ppm/6HEye: Other eye effects

Behavioral: Ataxia
JAPTO* 23,387,2003
inhalation/rat lowest published toxic concentration: 3500 ppm/6HLung, Thorax, or Respiration: Respiratory depressionJAPTO* 23,387,2003
inhalation/rat lowest published toxic concentration: 1500 ppm/6HBehavioral: SleepJAPTO* 23,387,2003
inhalation/rat lowest published toxic concentration: 2500 ppm/6HBehavioral: Somnolence (general depressed activity)JAPTO* 23,419,2003
inhalation/rat lowest published toxic concentration: 100 ppm/6HBehavioral: AtaxiaJAPTO* 23,419,2003
inhalation/rat lethal concentration (50 percent kill): 31800 mg/m3Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
inhalation/rat lowest published toxic concentration: 100 ppm/6HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TOXID9 44,193,2005
inhalation/rat lowest published toxic concentration: 100 ppm/6HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)TOXID9 44,193,2005
inhalation/rat lethal concentration (50 percent kill): >5400 mg/m3/4HLung, Thorax, or Respiration: Pulmonary emboliNTIS** OTS0557658
oral/mouse lethal dose (50 percent kill): 3333 mg/kgBrain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
oral/rat lethal dose (50 percent kill): 3500 mg/kgBrain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
oral/rat lowest published toxic dose: 500 mg/kgSkin: After systemic exposure: PhotosensitivityTOXID9 90,370,2006
oral/rat lethal dose (50 percent kill): 2100 mg/kgHPV156 -,-,2007
oral/rat lethal dose (50 percent kill): 1602 mg/kgBehavioral: Ataxia

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0557624
skin/rabbit lethal dose (50 percent kill): >3160 mg/kgSkin: After topical application: Primary irritationHPV156 -,-,2007
skin/rabbit Lethal dose: >3160 mg/kgOlfaction: Other olfaction effects

Gastrointestinal: Other changes

Musculoskeletal: Other changes
NTIS** OTS0557626

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3500 ppm/7D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 23,387,2003
inhalation/mouse lowest published toxic concentration: 3500 ppm/5D- intermittentLung, Thorax, or Respiration: Respiratory depressionJAPTO* 23,387,2003
inhalation/mouse lowest published toxic concentration: 3500 ppm/2D- intermittentBehavioral: TremorJAPTO* 23,387,2003
inhalation/mouse lowest published toxic concentration: 1500 ppm/11D- intermittentLiver: Changes in liver weightJAPTO* 23,387,2003
inhalation/mouse lowest published toxic concentration: 1500 ppm/5D- intermittentEye: Other eye effects

Behavioral: Tremor
JAPTO* 23,387,2003
inhalation/mouse lowest published toxic concentration: 2500 ppm/6H/13W- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 42,251,1998
inhalation/mouse lowest published toxic concentration: 3000 ppm/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV156 -,-,2007
inhalation/mouse lowest published toxic concentration: 2500 ppm/13W- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV156 -,-,2007
inhalation/rat lowest published toxic concentration: 3500 ppm/13W- intermittentBrain and Coverings: Changes in brain weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV156 -,-,2007
inhalation/rat lowest published toxic concentration: 2000 ppm/6H/4W- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Liver: Liver function tests impaired
NTIS** OTS0535711
inhalation/rat lowest published toxic concentration: 3500 ppm/6H/13W- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 42,251,1998
inhalation/rat lowest published toxic concentration: 3500 ppm/14D- intermittentLiver: Changes in liver weightJAPTO* 23,387,2003
inhalation/rat lowest published toxic concentration: 1500 ppm/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 23,387,2003
inhalation/rat lowest published toxic concentration: 3500 ppm/3D- intermittentBehavioral: TremorJAPTO* 23,387,2003
inhalation/rat lowest published toxic concentration: 2000 ppm/4W- intermittentBehavioral: Coma

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HPV156 -,-,2007
inhalation/rat lowest published toxic concentration: 4000 ppm/4W- intermittentBehavioral: Coma

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV156 -,-,2007
oral/rat lowest published toxic dose: 29000 mg/kg/29D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV156 -,-,2007
oral/rat lowest published toxic dose: 4.2 gm/kg/2W- continuousReproductive: Effects on fertility: Other measures of fertilityREPTED 17,273,2003
oral/rat lowest published toxic dose: 14 gm/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight
JJATDK 15,313,1995

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,387,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (85 mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (84 mg/m3), NOV2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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