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Butane, 2 - methoxy - 2 - methyl -

RTECS #: EK4421000

CAS #: 994-05-8


UPDATE: February 2009 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylpropyl methyl ether
  2. 2 - Methoxy - 2 - methylbutane
  3. Ether, methyl tert - pentyl (6CI,7CI,8CI)
  4. Methyl tert - amyl ether
  5. Methyl 1,1 - dimethylpropyl ether
  1. Methyl tert - pentyl ether
  2. TAME
  3. TAME (ether)
  4. tert - Amyl methyl ether
  5. tert - Pentyl methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 ÁL/24 hour severe NTIS** OTS0557627
skin
rabbit
500 ÁL/4 hour severe NTIS** OTS0557664


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 3,500 ppm/6 hour (6-19 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** OTS0558880
inhalation
mouse
lowest published toxic concentration: 3,500 ppm (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
JAPTO* 23,387,2003
inhalation
mouse
lowest published toxic concentration: 1,500 ppm (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 3,500 ppm/6 hour (6-19 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0558879
inhalation
rat
lowest published toxic concentration: 3,500 ppm (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JAPTO* 23,387,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 27,400 mg/m3 Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
inhalation
mouse
lowest published lethal concentration: 3,500 ppm/6 hour Eye: Other eye effects

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
JAPTO* 23,387,2003
inhalation
mouse
lowest published lethal concentration: 3,500 ppm/6 hour Behavioral: Sleep

Blood: Hemorrhage
JAPTO* 23,387,2003
inhalation
mouse
lowest published toxic concentration: 100 ppm/6 hour Behavioral: Change in motor activity (specific assay) JAPTO* 23,419,2003
inhalation
rat
lethal concentration (50 percent kill): >5,400 mg/m3/4 hour Lung, Thorax, or Respiration: Pulmonary emboli NTIS** OTS0557658
inhalation
rat
lethal concentration (50 percent kill): 31,800 mg/m3 Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TOXID9 44,193,2005
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) TOXID9 44,193,2005
inhalation
rat
lowest published toxic concentration: 3,500 ppm/6 hour Eye: Other eye effects

Behavioral: Ataxia
JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 3,500 ppm/6 hour Lung, Thorax, or Respiration: Respiratory depression JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 1,500 ppm/6 hour Behavioral: Sleep JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 2,500 ppm/6 hour Behavioral: Somnolence (general depressed activity) JAPTO* 23,419,2003
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour Behavioral: Ataxia JAPTO* 23,419,2003
oral
mouse
lethal dose (50 percent kill): 3,333 mg/kg Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
oral
rat
lethal dose (50 percent kill): 1,602 mg/kg Behavioral: Ataxia

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0557624
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic
VCVGK* -,269,1994
oral
rat
lowest published toxic dose: 500 mg/kg Skin: After systemic exposure: Photosensitivity TOXID9 90,370,2006
skin
rabbit
lethal dose : >3,160 mg/kg Olfaction: Other olfaction effects

Gastrointestinal: Other changes

Musculoskeletal: Other changes
NTIS** OTS0557626


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2,500 ppm/6 hour/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 42,251,1998
inhalation
mouse
lowest published toxic concentration: 3,500 ppm/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 23,387,2003
inhalation
mouse
lowest published toxic concentration: 3,500 ppm/5 day- intermittent Lung, Thorax, or Respiration: Respiratory depression JAPTO* 23,387,2003
inhalation
mouse
lowest published toxic concentration: 3,500 ppm/2 day- intermittent Behavioral: Tremor JAPTO* 23,387,2003
inhalation
mouse
lowest published toxic concentration: 1,500 ppm/11 day- intermittent Liver: Changes in liver weight JAPTO* 23,387,2003
inhalation
mouse
lowest published toxic concentration: 1,500 ppm/5 day- intermittent Eye: Other eye effects

Behavioral: Tremor
JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 2,000 ppm/6 hour/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Liver: Liver function tests impaired
NTIS** OTS0535711
inhalation
rat
lowest published toxic concentration: 3,500 ppm/6 hour/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 42,251,1998
inhalation
rat
lowest published toxic concentration: 3,500 ppm/14 day- intermittent Liver: Changes in liver weight JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 1,500 ppm/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 23,387,2003
inhalation
rat
lowest published toxic concentration: 3,500 ppm/3 day- intermittent Behavioral: Tremor JAPTO* 23,387,2003
oral
rat
lowest published toxic dose: 14 gm/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight
JJATDK 15,313,1995
oral
rat
lowest published toxic dose: 4.2 gm/kg/2 week- continuous Reproductive: Effects on fertility: Other measures of fertility REPTED 17,273,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,387,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (85 mg/m3), MAR2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an oxygenate to reduce carbon monoxide emissions
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an oxygenate to reduce carbon monoxide emissions

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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