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Registry of Toxic Effects of Chemical Substances (RTECS)

Butane, 1,2-epoxy-

RTECS #

EK3675000

CAS #

106-88-7

Updated

December 2013

Molecular Weight

72.12

Molecular Formula

C4H8O

Synonyms

1,2-Butene oxide
1,2-Butylene oxide
1,2-Epoxybutane
1-Butene oxide
Butylene oxide
Ethyl ethylene oxide
Ethyl oxirane
Ethylene oxide, ethyl-
Ethyloxirane
NCI-C55527

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,770,1986
skin /rabbit 500 mg/24H mild85JCAE -,770,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
DNA Damagelymphocyte/mammal (species unspecified)100 mmol/LCBINA8 9,97,1974
DNA Damagemammary gland/human78 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA Damageleukocyte/human1000 µmol/L/2HMUREAV 747,1,2012
DNA Damageleukocyte/human100 µmol/L/24HMUREAV 747,1,2012
DNA Damageother cell types/human2000 µmol/L/2HMUREAV 747,1,2012
DNA Damageother cell types/human1000 µmol/L/24HMUREAV 747,1,2012
DNA repair/Escherichia coli50 mg/LJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae6000 ppmJJIND8 62,901,1979
heritable translocation testoral/Drosophila melanogaster5 pphENMUDM 7,349,1985
morphological transformembryo/rat700 mg/LJJIND8 67,1303,1981
morphological transformembryo/hamster50 µg/LJJIND8 67,1303,1981
mutation in mammalian somatic cellslymphocyte/mouse400 mg/LENMUDM 9,143,1987
mutation in microorganisms/Salmonella typhimurium8.9 mg/L/2H (-enzymatic activation step)MUREAV 578,210,2005
mutation in microorganisms/Saccharomyes cerevisiae16740 mg/L/16HMUTAEX 20,105,2004
mutation in microorganisms/Salmonella typhimurium2 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganismslymphocyte/mouse400 mg/L (+enzymatic activation step)ENMUDM 9,143,1987
mutation in microorganisms/Schizosaccharomyces pombe1600 µmol/L (+enzymatic activation step)TCMUD8 3,75,1983
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980
mutation in microorganisms/Salmonella typhimurium3333 µg/plate (+enzymatic activation step)MUREAV 172,105,1986
mutation in microorganisms/Klebsiella pneumoniae1 mmol/L (-enzymatic activation step)MUREAV 89,269,1981
other mutation test systems/Salmonella typhimurium780 mg/LMUREAV 192,239,1987
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5 pphENMUDM 7,349,1985
sister chromatid exchangelung/hamster2500 µmol/LMUREAV 249,55,1991
specific locus testoral/Drosophila melanogaster5 pph/72HNTPTR* NTP-TR-329,1988
specific locus testinhalation/Drosophila melanogaster3800 ppmMUREAV 405,259,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit 1000 ppm/7H (1-24D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** PB81-168510

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3090 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB88-216262/AS
inhalation/rat lowest published toxic concentration: 400 ppm/6H/5D/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-329,1988
inhalation/rat lowest published toxic concentration: 12360 mg/kg/13W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB88-216262/AS
inhalation/rat lowest published toxic concentration: 10300 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB88-216262/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 398 ppm/4HNTPTR* NTP-TR-329,1988
inhalation/rat lethal concentration (50 percent kill): 6300 mg/m3/4HNTIS** OTS0528421
oral/rat lethal dose (50 percent kill): 500 mg/kgNTIS** PB81-168510
skin/rabbit lethal dose (50 percent kill): 2100 µL/kgAIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 800 ppm/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-329,1988
inhalation/mouse lowest published toxic concentration: 400 ppm/6H/13W- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-329,1988
inhalation/mouse lowest published toxic concentration: 1600 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 1,319,1981
inhalation/mouse lowest published toxic concentration: 600 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,319,1981
inhalation/rat lowest published toxic concentration: 800 ppm/6H/13W- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-329,1988
inhalation/rat lowest published toxic concentration: 1600 ppm/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-329,1988
inhalation/rat lowest published toxic concentration: 600 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,319,1981

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 47,217,1989
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,629,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adquate DataIMEMDT 71,629,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,629,1999
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9126; Number of Industries 166; Total Number of Facilities 14049; Number of Occupations 104; Total Number of Employees Exposed 261650; Total Number of Female Employees Exposed 42961

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse
On EPA IRIS database
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