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Butane, 1,2 - epoxy -

RTECS #: EK3675000

CAS #: 106-88-7


UPDATE: November 2007 MW: 72.12 MF: C4H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Butene oxide
  2. 1,2 - Butylene oxide
  3. 1,2 - Epoxybutane
  4. 1 - Butene oxide
  5. Butylene oxide
  1. Ethyl ethylene oxide
  2. Ethyl oxirane
  3. Ethylene oxide, ethyl -
  4. Ethyloxirane
  5. NCI - C55527


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,770,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,770,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
DNA damage human mammary gland 78 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage mammal (species unspecified) lymphocyte 100 mmol/L CBINA8 9,97,1974
DNA repair Escherichia coli 50 mg/L JJIND8 62,873,1979
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Klebsiella pneumoniae 1 mmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms mouse lymphocyte 400 mg/L (+enzymatic activation step) ENMUDM 9,143,1987
mutation in microorganisms Salmonella typhimurium 3,333 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
mutation in microorganisms Salmonella typhimurium 2 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
mutation in microorganisms Salmonella typhimurium 8.9 mg/L/2 hour (-enzymatic activation step) MUREAV 578,210,2005
mutation in microorganisms Saccharomyes cerevisiae 16,740 mg/L/16 hour MUTAEX 20,105,2004
mutation in microorganisms Schizosaccharomyces pombe 1,600 µmol/L (+enzymatic activation step) TCMUD8 3,75,1983
gene conversion and mitotic recombination Saccharomyes cerevisiae 6,000 ppm JJIND8 62,901,1979
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L ENMUDM 9,143,1987
morphological transform hamster embryo 50 µg/L JJIND8 67,1303,1981
morphological transform rat embryo 700 mg/L JJIND8 67,1303,1981
other mutation test systems Salmonella typhimurium 780 mg/L MUREAV 192,239,1987
sister chromatid exchange hamster lung 2,500 µmol/L MUREAV 249,55,1991
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
5 pph ENMUDM 7,349,1985
specific locus test oral
Drosophila melanogaster
5 pph/72 hour NTPTR* NTP-TR-329,1988
specific locus test inhalation
Drosophila melanogaster
3,800 ppm MUREAV 405,259,1998
heritable translocation test oral
Drosophila melanogaster
5 pph ENMUDM 7,349,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rabbit
lowest published toxic concentration: 1,000 ppm/7 hour (1-24 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB81-168510


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 3,090 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB88-216262/AS
inhalation
rat
lowest published toxic concentration: 400 ppm/6 hour/5 day/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-329,1988
inhalation
rat
lowest published toxic concentration: 12,360 mg/kg/13 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB88-216262/AS
inhalation
rat
lowest published toxic concentration: 10,300 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB88-216262/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 398 ppm/4 hour N/R NTPTR* NTP-TR-329,1988
inhalation
rat
lethal concentration (50 percent kill): 6,300 mg/m3/4 hour N/R NTIS** OTS0528421
oral
rat
lethal dose (50 percent kill): 500 mg/kg N/R NTIS** PB81-168510
skin
rabbit
lethal dose (50 percent kill): 2,100 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 800 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-329,1988
inhalation
mouse
lowest published toxic concentration: 400 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight NTPTR* NTP-TR-329,1988
inhalation
mouse
lowest published toxic concentration: 1,600 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 1,319,1981
inhalation
mouse
lowest published toxic concentration: 600 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,319,1981
inhalation
rat
lowest published toxic concentration: 800 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight NTPTR* NTP-TR-329,1988
inhalation
rat
lowest published toxic concentration: 1,600 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-329,1988
inhalation
rat
lowest published toxic concentration: 600 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,319,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 47,217,1989
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,629,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adquate Data IMEMDT 71,629,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,629,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (tentative), OCT 2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9126;
Number of Industries 166;
Total Number of Facilities 14,049;
Number of Occupations 104;
Total Number of Employees Exposed 261,650;
Total Number of Female Employees Exposed 42,961


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as stabilizer in chlorinated solvents
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used as stabilizer in chlorinated solvents

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (ORGANIC OXIDES OR EPOXY COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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