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Registry of Toxic Effects of Chemical Substances (RTECS)

Butane, 1-chloro-

RTECS #

EJ6300000

CAS #

109-69-3

Updated

July 2011

Molecular Weight

92.58

Molecular Formula

C4H9Cl

Synonyms

1-Chlorobutane
Butyl chloride
Chlorure de butyle (French)
n-Butyl chloride
NCI-C06155
n-Propylcarbinyl chloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslymphocyte/mouse500 mg/LNTPTR* NTP-TR-312,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 13927 mg/kg (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathGISAAA 44(3),11,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 257500 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** PB86-218526/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAMIHBC 10,61,1954
oral/mouse lethal dose (50 percent kill): 5600 mg/kgVCVGH* -,401,1990
oral/rat lethal dose (50 percent kill): 2200 mg/kgVCVGH* -,401,1990
skin/rabbit lowest published lethal dose: 20 gm/kg34ZIAG -,745,1969
unreported route/guinea pig lethal dose (50 percent kill): 8 gm/kgVRDEA5 (7),105,1979
unreported route/mouse lethal dose (50 percent kill): 5600 mg/kgGISAAA 44(3),11,1979
unreported route/rat lethal dose (50 percent kill): 2200 mg/kgVRDEA5 (7),105,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 21 gm/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-312,1986
oral/mouse lowest published toxic dose: 65 gm/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-312,1986
oral/rat lowest published toxic dose: 364 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 44(3),11,1979
oral/rat lowest published toxic dose: 10500 mg/kg/14D- intermittentBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-312,1986
oral/rat lowest published toxic dose: 32500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-312,1986

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 25 ppm (96 mg/m3);KZW 25 ppm (96 mg/m3), 2007
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3168; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 4; Total Number of Employees Exposed 3202; Total Number of Female Employees Exposed 880

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
On EPA IRIS database
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