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Registry of Toxic Effects of Chemical Substances (RTECS)

Butane, 1,4-bis(2,3-epoxypropoxy)-

RTECS #

EJ5100000

CAS #

2425-79-8

Updated

February 2006

Molecular Weight

202.28

Molecular Formula

C10H18O4

Synonyms

1,4-Bis(2,3-epoxypropoxy)butane
1,4-Bis(glycidyloxy)butane
1,4-Butane diglycidyl ether
1,4-Butanediol diglycidyl ether
1,4-Diglycidloxybutane
2,2'-(1,4-Butanediylbis(oxymethylene))bisoxirane
Araldit DY 026
Butane-1:4-diol diglycidyl ether
Butanediol diglycidyl ether
CD 15006 A
ChS-RR2
Grilonit RV 1806
Oxirane, 2,2'-(1,4-butanediylbis(oxymethylene))bis- (9CI)
TK 10352

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg moderateAMIHAB 20,390,1959
skin /rabbit 10 mg/24H moderateAMIHAB 20,390,1959

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat100 mg/kgBJPCAL 6,235,1951
heritable translocation testoral/Drosophila melanogaster28 ppbEMMUEG 23,51,1994
mutation in microorganisms/Salmonella typhimurium333 µg/plate (+enzymatic activation step)MUREAV 172,105,1986
other mutation test systems/Escherichia coli300 µmol/LMUREAV 231,205,1990
sister chromatid exchangelung/hamster6250 nmol/LMUREAV 249,55,1991
specific locus testoral/Drosophila melanogaster28400 ppmEMMUEG 23,51,1994

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 32960 mg/kg/2Y- intermittentNutritional and Gross Metabolic: Dehydration

Skin and Appendages: Tumors
NTIS** OTS0571421

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >250 ppm/6HNTIS** OTS0555389
oral/hamster lethal dose (50 percent kill): 3462 mg/kgEye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NTIS** OTS0523586
oral/mouse lethal dose (50 percent kill): 1100 µg/kgNTIS** OTS0555389
oral/rat lethal dose (50 percent kill): 1134 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
TSCAT* OTS0206386
skin/rabbit lethal dose (50 percent kill): 1130 mg/kgAMIHAB 20,390,1959

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 8470 mg/kg/11D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555389

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2226; Number of Industries 3; Total Number of Facilities 43; Number of Occupations 3; Total Number of Employees Exposed 606; Total Number of Female Employees Exposed 51

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8891
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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