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1,3 - Butadiene, 2 - chloro -

RTECS #: EI9625000

CAS #: 126-99-8


UPDATE: May 2009 MW: 88.54 MF: C4H5Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Chloor - 1,3 - butadieen (Dutch)
  2. 2 - Chlor - 1,3 - butadien (German)
  3. 2 - Chloro - 1,3 - butadiene
  4. 2 - Chloro - 1,3 - butadiene (OSHA)
  5. 2 - Chlorobuta - 1,3 - diene
  6. 2 - Cloro - 1,3 - butadiene (Italian)
  7. Chlorobutadiene
  1. Chloropreen (Dutch)
  2. Chloropren (German, Polish)
  3. Chloroprene
  4. Cloroprene (Italian)
  5. beta - Chloroprene
  6. beta - Chloroprene (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 L/24 hour severe NTIS** OTS0535986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis unreported route
human
1 mg/m3 MUREAV 147,301,1985
cytogenetic analysis inhalation
mouse
320 g/m3/4 week- continuous GTPZAB 20(3),31,1976
cytogenetic analysis inhalation
rat
1,960 g/m3/16 week BZARAZ 27(6),102,1974
dominant lethal test inhalation
rat
4 g/L/48 day- intermittent TNICS* 13,56,1973
DNA damage inhalation
mouse
32 ppm/104 week- intermittent CBINA8 135-136,373,2001
host-mediated assay mouse
Salmonella typhimurium
375 mg/kg/4 hour ZKMAAX 16,41,1976
mutation in microorganisms Salmonella typhimurium 70 mol/L (+enzymatic activation step) NATUAS 255,641,1975
mutation in microorganisms Salmonella typhimurium 2 pph/4 hour (-enzymatic activation step) ARTODN 41,249,1979
micronucleus test inhalation
mouse
1,480 g/m3/2 hour/2 day- continuous HYDXET 17,209,1986
morphological transform hamster embryo 125 mg/L AETODY 1,241,1980
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
5,700 mol/L/3 day- intermittent 35WYAM -,63,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4 mg/m3/24 hour (3-4 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death GTPZAB 19(3),30,1975
inhalation
rat
lowest published toxic concentration: 4 mg/m3/24 hour (11-12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system GTPZAB 19(3),30,1975
inhalation
rat
lowest published toxic concentration: 10 ppm/4 hour (3-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 44,81,1978
inhalation
rat
lowest published toxic concentration: 150 g/m3/24 hour (19 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) EVHPAZ 17,85,1976
inhalation
rat
lowest published toxic concentration: 500 mg/m3/5 hour (17 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders BEBMAE 60(7),107,1965
inhalation
rat
lowest published toxic concentration: 500 mg/m3/5 hour (30 week prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes BEBMAE 60(7),107,1965
inhalation
rat
lowest published toxic concentration: 0.15 mg/m3 (multigenerations) Reproductive: Effects on embryo or fetus: Fetal death VCVGH* -,505,1990
inhalation
rat
lowest published toxic concentration: 0.38 gm/m3 (48 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TPKVAL 13,58,1973
oral
rat
lowest published toxic dose: 9,100 g/kg (26 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GISAAA 45(2),17,1980
oral
rat
lowest published toxic dose: 1 mg/kg (11-12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system GTPZAB 19(3),30,1975
oral
rat
lowest published toxic dose: 1 mg/kg (11-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) GTPZAB 19(7),30,1975
oral
rat
lowest published toxic dose: 1 mg/kg (9-10 day pregnant) Reproductive: Other developmental abnormalities GTPZAB 19(7),30,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 32 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-467,1998
inhalation
mouse
lowest published toxic concentration: 32 ppm/6 hour/104 week - intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CBINA8 135-136,373,2001
inhalation
mouse
lowest published toxic concentration: 80 ppm/5 hour/104 week - intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CBINA8 135-136,373,2001
inhalation
mouse
lowest published toxic concentration: 791.04 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB99-123671
inhalation
mouse
lowest published toxic concentration: 1,977.6 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Liver: Tumors
NTIS** PB99-123671
inhalation
rat
lowest published toxic concentration: 80 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTPTR* NTP-TR-467,1998
inhalation
rat
lowest published toxic concentration: 988.9 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** PB99-123671
inhalation
rat
lowest published toxic concentration: 2,060 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors
NTIS** PB99-123671


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 1,290 mg/m3/8 hour N/R JIHTAB 18,240,1936
inhalation
cat
lowest published lethal concentration: 3,500 mg/m3/2 hour N/R VCVGH* -,504,1990
inhalation
human
lowest published toxic concentration: 100 mg/kg/5 minute Eye: Lacrimation

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVGH* -,505,1990
inhalation
mouse
lowest published lethal concentration: 600 mg/m3/8 hour N/R VCVGH* -,504,1990
inhalation
mouse
lethal concentration (50 percent kill): 2,300 mg/m3/2 hour N/R VCVGH* -,504,1990
inhalation
mouse
lethal concentration (50 percent kill): 1,600 mg/m3 N/R VCVGH* -,504,1990
inhalation
rat
lethal concentration (50 percent kill): 11,800 mg/m3/4 hour N/R 85GMAT -,38,1982
inhalation
rat
lethal concentration (50 percent kill): 300 mg/m3 N/R VCVGH* -,504,1990
inhalation
rat
lowest published toxic concentration: 17,000 mg/kg/5 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVGH* -,504,1990
inhalation
rabbit
lowest published lethal concentration: 3,870 mg/m3/8 hour N/R JIHTAB 18,240,1936
inhalation
rabbit
lowest published lethal concentration: 6,000 mg/m3/2 hour N/R VCVGH* -,504,1990
intravenous
rabbit
lowest published lethal dose: 96 mg/kg Blood: Other changes

Skin: After systemic exposure: Dermatitis, other
SBLEA2 44,63,1942
oral
mouse
lethal dose (50 percent kill): 146 mg/kg N/R 85GMAT -,38,1982
oral
rat
lethal dose (50 percent kill): 450 mg/kg N/R 85GMAT -,38,1982
subcutaneous
cat
lowest published lethal dose: 100 mg/kg N/R JIHTAB 18,240,1936
subcutaneous
mouse
lowest published lethal dose: 1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JIHTAB 18,240,1936
subcutaneous
pigeon
lowest published lethal dose: 13 gm/kg N/R JIHTAB 18,240,1936
subcutaneous
rat
lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
JIHTAB 18,240,1936
unreported route
mouse
lethal dose (50 percent kill): 146 mg/kg N/R VCVGH* -,504,1990
unreported route
rat
lethal dose (50 percent kill): 119 mg/kg N/R VCVGH* -,504,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 162 ppm/6 hour/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 46,375,1978
inhalation
hamster
lowest published toxic concentration: 50 ppm/6 hour/78 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHTE5 10,443,1998
inhalation
mouse
lowest published toxic dose: 1,260 mg/m3/14 day- intermittent Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
ZYYZEW 3,125,1989
inhalation
mouse
lowest published toxic concentration: 200 mg/m3/24 hour/91 day- continuous Gastrointestinal: Ulceration or bleeding from large intestine

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 18,240,1936
inhalation
rat
lowest published toxic concentration: 161 ppm/6 hour/4 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 46,375,1978
inhalation
rat
lowest published toxic concentration: 220 g/m3/24 hour/60 day- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 29(9),13,1964
inhalation
rat
lowest published toxic concentration: 200 mg/m3/24 hour/91 day- continuous Brain and Coverings: Other degenerative changes

Gastrointestinal: Ulceration or bleeding from large intestine

Blood: Changes in spleen
JIHTAB 18,240,1936
inhalation
rat
lowest published toxic concentration: 50 ppm/6 hour/2 year- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 10,443,1998
inhalation
rat
lowest published toxic concentration: 32 ppm/6 hour/16 day- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-467,1998
inhalation
rat
lowest published toxic concentration: 0.39 gm/m3/48 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 13,58,1973
intraperitoneal
rat
lowest published toxic dose: 168 mg/kg/21 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Other changes

Blood: Other changes
WDZAEK 6,126,1992
oral
mouse
lowest published toxic dose: 63 mg/m3/21 day- intermittent Immunological Including Allergic: Decreased immune response ZYYZEW 2,57,1988
oral
rat
lowest published toxic dose: 9,100 g/kg/26 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 45(2),17,1980
oral
rat
lowest published toxic dose: 1,680 mg/kg/3 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
ZYYZEW 9,283,1995
subcutaneous
mouse
lowest published toxic dose: 42 mg/kg/21 day- intermittent Immunological Including Allergic: Decreased immune response

Biochemical: Metabolism (intermediary): Other proteins
ZYYZEW 2,57,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin) DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,227,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,131,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 19,131,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,227,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,227,1999
TOXICOLOGY REVIEW
CTOXAO 13,153,1978
TOXICOLOGY REVIEW
CBINA8 135-136,27,2001
TOXICOLOGY REVIEW
CBINA8 135-136,81,2001
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 566,49,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (90 mg/m3) (skin) DTLVS* 3,54,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (90 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (90 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (90 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (90 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (36 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (37 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 1 ppm (3.6 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (36 mg/m3), short term exposure limit 20 ppm (72 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (36 mg/m3), continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 18 mg/m3, short term exposure limit 72 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (35 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (45 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 18 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (36 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3.6 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, short term exposure limit, 16 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (3.5 mg/m3);
short term exposure limit 5 ppm (18 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (18 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO beta-CHLOROPRENE-air Carcinogen ceiling concentration 1 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18260;
Number of Industries 39;
Total Number of Facilities 3,538;
Number of Occupations 26;
Total Number of Employees Exposed 43,712
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18260;
Number of Industries 17;
Total Number of Facilities 1,864;
Number of Occupations 21;
Total Number of Employees Exposed 17,750;
Total Number of Female Employees Exposed 654


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Sperm morphology-rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the production of polychloroprene elastomers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 1, 1975
NIOSH Analytical Method, 1994: beta-Chloroprene, 1002
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #112


REFERENCES:

CODEN
REFERENCE

35WYAM "In Vitro Metabolic Activation in Mutagenic Testing, Proceedings of the Symposium, Research Triangle Park, NC, 1976," De Serres, F.J., et al., eds., New York, Elsevier Science Pub. Co., Inc., 1976
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HYDXET Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.17- 1986-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SBLEA2 Sbornik Lekarsky. Collection of Medical Works. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1887-
TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR)
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962-
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-

Used in the production of polychloroprene elastomers

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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