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Registry of Toxic Effects of Chemical Substances (RTECS)

Brucine

RTECS #

EH8925000

CAS #

357-57-3

Updated

July 2013

Molecular Weight

394.51

Molecular Formula

C23H26N2O4

Synonyms

(-)-Brucine
10,11-Dimethystrychnine
2,3-Dimethoxystrychnidin-10-one
2,3-Dimethoxy-strychnine
Brucina (Italian)
Brucine alkaloid
Dimethoxy strychnine
RCRA waste number P018
Strychnidin-10-one, 2,3-dimethoxy- (9CI)
Strychnine, 2,3-dimethoxy-

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 59.6 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/mouse lowest published toxic dose: 10.3 mg/kgBehavioral: AnalgesiaJOETD7 88,205,2003
intraperitoneal/mouse lethal dose (50 percent kill): 62 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 35,295,1992
intraperitoneal/rat lethal dose (50 percent kill): 91 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Rigidity (includes catalepsy)

Behavioral: Muscle contraction or spasticity
JPETAB 131,185,1961
intraperitoneal/rat lowest published toxic dose: 15 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 88,205,2003
intraperitoneal/rat lowest published toxic dose: 7 mg/kgBehavioral: AnalgesiaJOETD7 88,205,2003
intravenous/Dog lowest published lethal dose: 8 mg/kgHBAMAK 4,1289,1935
intravenous/guinea pig lowest published lethal dose: 120 mg/kgNTIS** PB214-270
intravenous/mouse lethal dose (50 percent kill): 12 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 35,295,1992
intravenous/rabbit lowest published lethal dose: 30 mg/kgNTIS** PB214-270
oral/mouse lethal dose (50 percent kill): 150 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 35,295,1992
subcutaneous/mouse lethal dose (50 percent kill): 60 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPSXAS 7,329,1970
subcutaneous/pigeon lowest published lethal dose: 58 mg/kgHBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 300 mg/kg/20D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 88,205,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84459; Number of Industries 2; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 334; Total Number of Female Employees Exposed 119
National Occupational Hazard Survey 1974Hazard Code 84459; Number of Industries 2; Total Number of Facilities 109; Number of Occupations 3; Total Number of Employees Exposed 150

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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