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Registry of Toxic Effects of Chemical Substances (RTECS)

Bromic acid, sodium salt

RTECS #

EF8750000

CAS #

7789-38-0

Updated

October 2012

Molecular Weight

150.90

Molecular Formula

BrO3·Na

Synonyms

Bromate de sodium (French)
Dyetone
Neutralizer K 126
Neutralizer K 140
Neutralizer K 938
Sodium bromate (NaBrO3)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
specific locus testother cell types/mouse100 mg/L/4HMUREAV 537,21,2003
specific locus testother cell types/mouse0.66 mmol/L/4HMUREAV 537,21,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 140 mg/kgCOREAF 257,791,1963
intravenous/rabbit lowest published lethal dose: 360 mg/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Blood: Other changes
SAPHAO 30,337,1913
oral/rabbit lowest published lethal dose: 250 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Blood: Other changes
SAPHAO 30,337,1913
oral/woman lowest published toxic dose: 150 mg/kgEar: Change in acuity

Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
JFASEO 92(Suppl 4),S262,1993
subcutaneous/Dog lowest published lethal dose: 120 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other changes
SAPHAO 30,337,1913
subcutaneous/guinea pig lowest published lethal dose: 100 mg/kgLung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes
SAPHAO 30,337,1913

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 4480 mg/kg/28D- continuousEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)
TOXID9 54,156,2000
oral/mouse lowest published toxic dose: 2912 mg/kg/26W- continuousKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 66,184,2002
oral/mouse lowest published toxic dose: 2912 mg/kg/26W- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductTOXID9 66,184,2002
oral/mouse lowest published toxic dose: 448 mg/kg/28D- intermittentEndocrine: Changes in spleen weightNTPTR* IMM-98004
oral/mouse lowest published toxic dose: 4480 mg/kg/28D- intermittentBlood: Normocytic anemia

Blood: Changes in cell count (unspecified)
NTPTR* IMM-98004
oral/mouse lowest published toxic dose: 3360 mg/kg/28D- intermittentImmunological Including Allergic: Increase in cellular immune responseNTPTR* IMM-98004
oral/mouse lowest published toxic dose: 1120 mg/kg/28D- intermittentImmunological Including Allergic: Uncharacterized (multiple organ involvement)NTPTR* IMM-98004
oral/rat lowest published toxic dose: 896 mg/kg/35D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* RDGT94007
oral/rat lowest published toxic dose: 3115 mg/kg/35D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesNTPTR* RDGT94007
skin/mouse lowest published toxic dose: 11648 mg/kg/26W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Tumorigenic: Tumors at site of application
TOXID9 66,184,2002
skin/mouse lowest published toxic dose: 11648 mg/kg/26W- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductTOXID9 66,184,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 751,49,2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4132; Number of Industries 5; Total Number of Facilities 2680; Number of Occupations 9; Total Number of Employees Exposed 27921; Total Number of Female Employees Exposed 18633

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
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