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Registry of Toxic Effects of Chemical Substances (RTECS)

Bromic acid, potassium salt

RTECS #

EF8725000

CAS #

7758-01-2

Updated

December 2013

Molecular Weight

167.01

Molecular Formula

BrO3·K

Synonyms

EEC No. E924
Potassium bromate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat251 mg/kgMUREAV 240,281,1990
Cytogenetic Analysisoral/rat3 mmol/kgMUREAV 147,274,1985
Cytogenetic Analysislung/hamster85 mg/LGMCRDC 27,95,1981
Cytogenetic Analysislymphocyte/human400 mg/L/24HMUREAV 626,48,2007
DNA Damageintraperitoneal/mouse320 mg/kg/4D- intermittentFCTOD7 46,1184,2008
DNA Damageovary/hamster20 mmol/L/15MTXCYAC 221,166,2006
DNA Damageoral/rat200 mg/kgMUREAV 630,28,2007
DNA Damageoral/rat3150 mg/kg/9W-continuousTXCYAC 257,46,2009
DNA Damageother cell types/mouse0.5 mmol/L/3HTXCYAC 267,45,2010
DNA Damagekidney/pig7500 µmol/LCRNGDP 16,335,1995
DNA Damageoral/mouse300 mg/kgMUREAV 493,39,2001
DNA Damageleukocyte/mouse7500 µmol/LCRNGDP 16,335,1995
DNA Damageovary/hamster7.195 mmol/L/4HEMMUEG 40,134,2002
DNA Damageovary/hamster2.5 mmol/L/3HFCTOD7 42,209,2004
DNA Damageintraperitoneal/rat80 mg/kgJJCREP 83,45,1992
DNA Damageother cell types/human1.5 mmol/L/1HMUREAV 726,151,2011
DNA Damageintraperitoneal/mouse100 mg/kgTXAPA9 250,147,2011
DNA repairovary/hamster5 mmol/L/3HFCTOD7 42,209,2004
micronucleus testintraperitoneal/mouse320 mg/kg/4D- intermittentFCTOD7 46,1184,2008
micronucleus testother cell types/mouse0.6 mmol/LMUREAV 655,4,2008
micronucleus testother cell types/mouse0.5 mmol/L/3HMUREAV 726,36,2011
micronucleus testother cell types/human0.1 mmol/L/24HMUREAV 678,30,2009
micronucleus testother cell types/human0.187 mmol/L/3HMUREAV 678,30,2009
micronucleus testother cell types/human0.7 mmol/L/2HMUREAV 678,30,2009
micronucleus testother cell types/human1.25 mmol/L/1HMUREAV 678,30,2009
micronucleus testintraperitoneal/rat60 mg/kgMUREAV 269,113,1992
micronucleus testintraperitoneal/mouse25 mg/kgFCTOD7 26,487,1988
micronucleus testoral/mouse200 mg/kg/24H-continuousFCTOD7 26,487,1988
micronucleus testovary/hamster5 mmol/L/3HFCTOD7 42,209,2004
micronucleus testlung/hamster125 mg/LMUREAV 272,223,1992
micronucleus testoral/mouse87.4 gm/kg/78W-continuousEMMUEG 36,283,2000
micronucleus testoral/mouse4.48 gm/kg/8W-continuousEMMUEG 36,283,2000
micronucleus testlymphocyte/human500 mg/L/24HMUREAV 626,48,2007
micronucleus testlung/hamster5000 µmol/L/6H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster10000 µmol/L/6H (+enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster1250 µmol/L/24H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster1250 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
mutation in microorganisms/Salmonella typhimurium3333 µg/plate (+enzymatic activation step)EMMUEG 19(Suppl 21),2,1992
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)AMONDS 3,253,1980
other mutation test systemsother cell types/human20 mmol/LMUREAV 614,37,2006
other mutation test systemsfibroblast/human20 mmol/LMUREAV 614,37,2006
sister chromatid exchangelymphocyte/human400 mg/L/48HMUREAV 626,48,2007
sister chromatid exchangeleukocyte/rat20 µmol/LMUREAV 300,241,1993
specific locus testother cell types/mouse100 mg/L/4HMUREAV 537,21,2003
specific locus testother cell types/mouse0.6 mmol/L/4HMUREAV 537,21,2003
specific locus testother cell types/human2.25 mmol/L/1HMUREAV 726,151,2011
specific locus testother cell types/human2000 units/LMUREAV 726,151,2011

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4200 mg/kg/13W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJCREP 78,358,1987
oral/rat lowest published toxic dose: 38500 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
GANNA2 73,335,1982
oral/rat toxic dose: 19635 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
ESKHA5 (100),93,1982
oral/rat toxic dose: 19250 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
GANNA2 73,335,1982
oral/rat toxic dose: 10500 mg/kg/39W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
JJCREP 78,358,1987
oral/rat toxic dose: 9625 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
ESKHA5 (100),93,1982
oral/rat toxic dose: 9625 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
EVHPAZ 69,221,1986
oral/rat toxic dose: 5460 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
JJIND8 77,977,1986
oral/rat lowest published toxic dose: 2400 mg/kg/16W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003
oral/rat lowest published toxic dose: 57.6 gm/kg/16W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 177 mg/kgMUREAV 223,399,1989
intraperitoneal/rat lowest published toxic dose: 125 mg/kgKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 201,173,2004
intraperitoneal/rat lethal dose (50 percent kill): 50 mg/kgJACTDZ 13,400,1994
oral/child lowest published toxic dose: 7125 µL/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
BMJOAE 1,1363,1951
oral/hamster lethal dose (50 percent kill): 388 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 87,309,1990
oral/human lowest published toxic dose: 714 mg/kgEar: Change in acuity

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NPRNAY 37,278,1984
oral/mouse lethal dose (50 percent kill): 289 mg/kgMUREAV 223,399,1989
oral/rat lethal dose (50 percent kill): 157 mg/kgOlfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea
ESKGA2 37,258,1991
subcutaneous/mouse lowest published toxic dose: 80 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 204,9,2005
unreported route/human lowest published lethal dose: 154 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
FCTOD7 47,2067,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 320 mg/kg/4D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,1184,2008
oral/mouse lowest published toxic dose: 336 mg/kg/14D- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ESKGA2 37,266,1991
oral/mouse lowest published toxic dose: 728 mg/kg/0.5Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,152,2001
oral/rat lowest published toxic dose: 28000 mg/kg/100W- continuousKidney, Ureter, and Bladder: Kidney tumorsTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 14000 mg/kg/100W- continuousEndocrine: Thyroid tumorsTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 7000 mg/kg/100W- continuousGastrointestinal: TumorsTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 1400 mg/kg/100W- continuousGastrointestinal: Other changes

Endocrine: Other changes
TXCYAC 221,158,2006
oral/rat lowest published toxic dose: 1.4 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changesTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 1.4 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 47,1154,2009
oral/rat lowest published toxic dose: 28 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Glycolytic

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 47,1154,2009
oral/rat lowest published toxic dose: 1260 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
EVHPAZ 87,309,1990
subcutaneous/guinea pig lowest published toxic dose: 280 mg/kg/14D- intermittentEar: Changes in vestibular functions

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001
subcutaneous/guinea pig lowest published toxic dose: 280 mg/kg/14D- intermittentBehavioral: Change in psychophysiological testsTXAPA9 177,103,2001
subcutaneous/guinea pig lowest published toxic dose: 700 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 40,207,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,481,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 40,207,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,481,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 73,481,1999
TOXICOLOGY REVIEWMUTAEX 15,431,2000
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWTXCYAC 221,190,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 636,242,2007
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 705,165,2010
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUREAV 751,49,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81949; Number of Industries 10; Total Number of Facilities 1458; Number of Occupations 24; Total Number of Employees Exposed 26562; Total Number of Female Employees Exposed 11090
National Occupational Hazard Survey 1974Hazard Code 81949; Number of Industries 6; Total Number of Facilities 132; Number of Occupations 9; Total Number of Employees Exposed 3252

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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