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Bromic acid, potassium salt

RTECS #: EF8725000

CAS #: 7758-01-2


UPDATE: May 2009 MW: 167.01 MF: BrO3ĽK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. EEC No. E924
  1. Potassium bromate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 85 mg/L GMCRDC 27,95,1981
cytogenetic analysis human lymphocyte 400 mg/L/24 hour MUREAV 626,48,2007
cytogenetic analysis intraperitoneal
rat
251 mg/kg MUREAV 240,281,1990
cytogenetic analysis oral
rat
3 mmol/kg MUREAV 147,274,1985
DNA damage hamster ovary 7.195 mmol/L/4 hour EMMUEG 40,134,2002
DNA damage hamster ovary 2.5 mmol/L/3 hour FCTOD7 42,209,2004
DNA damage hamster ovary 20 mmol/L/15 minute TXCYAC 221,166,2006
DNA damage mouse leukocyte 7,500 Ámol/L CRNGDP 16,335,1995
DNA damage intraperitoneal
mouse
150 mg/kg MUREAV 493,39,2001
DNA damage oral
mouse
300 mg/kg MUREAV 493,39,2001
DNA damage intraperitoneal
mouse
320 mg/kg/4 day- intermittent FCTOD7 46,1184,2008
DNA damage pig kidney 7,500 Ámol/L CRNGDP 16,335,1995
DNA damage intraperitoneal
rat
80 mg/kg JJCREP 83,45,1992
DNA damage oral
rat
200 mg/kg MUREAV 630,28,2007
DNA repair hamster ovary 5 mmol/L/3 hour FCTOD7 42,209,2004
mutation in microorganisms Salmonella typhimurium 3,333 Ág/plate (+enzymatic activation step) EMMUEG 19(Suppl 21),2,1992
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) AMONDS 3,253,1980
micronucleus test hamster lung 125 mg/L MUREAV 272,223,1992
micronucleus test hamster ovary 5 mmol/L/3 hour FCTOD7 42,209,2004
micronucleus test human lymphocyte 500 mg/L/24 hour MUREAV 626,48,2007
micronucleus test intraperitoneal
mouse
25 mg/kg FCTOD7 26,487,1988
micronucleus test oral
mouse
200 mg/kg/24 hour- continuous FCTOD7 26,487,1988
micronucleus test oral
mouse
87.4 gm/kg/78 week- continuous EMMUEG 36,283,2000
micronucleus test oral
mouse
4.48 gm/kg/8 week- continuous EMMUEG 36,283,2000
micronucleus test mouse other cell types 0.6 mmol/L MUREAV 655,4,2008
micronucleus test intraperitoneal
mouse
320 mg/kg/4 day- intermittent FCTOD7 46,1184,2008
micronucleus test intraperitoneal
rat
60 mg/kg MUREAV 269,113,1992
other mutation test systems human other cell types 20 mmol/L MUREAV 614,37,2006
other mutation test systems human fibroblast 20 mmol/L MUREAV 614,37,2006
sister chromatid exchange human lymphocyte 400 mg/L/48 hour MUREAV 626,48,2007
sister chromatid exchange rat leukocyte 20 Ámol/L MUREAV 300,241,1993
specific locus test mouse other cell types 100 mg/L/4 hour MUREAV 537,21,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 4,200 mg/kg/13 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJCREP 78,358,1987
oral
rat
lowest published toxic dose: 38,500 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
GANNA2 73,335,1982
oral
rat
toxic dose : 19,635 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
ESKHA5 (100),93,1982
oral
rat
toxic dose : 19,250 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
GANNA2 73,335,1982
oral
rat
toxic dose : 10,500 mg/kg/39 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
JJCREP 78,358,1987
oral
rat
toxic dose : 9,625 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
ESKHA5 (100),93,1982
oral
rat
toxic dose : 9,625 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
EVHPAZ 69,221,1986
oral
rat
toxic dose : 5,460 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
JJIND8 77,977,1986
oral
rat
lowest published toxic dose: 2,400 mg/kg/16 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003
oral
rat
lowest published toxic dose: 57.6 gm/kg/16 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 177 mg/kg N/R MUREAV 223,399,1989
intraperitoneal
rat
lethal dose (50 percent kill): 50 mg/kg N/R JACTDZ 13,400,1994
intraperitoneal
rat
lowest published toxic dose: 125 mg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 201,173,2004
oral
child
lowest published toxic dose: 7,125 ÁL/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
BMJOAE 1,1363,1951
oral
hamster
lethal dose (50 percent kill): 388 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 87,309,1990
oral
human
lowest published toxic dose: 714 mg/kg Ear: Change in acuity

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NPRNAY 37,278,1984
oral
mouse
lethal dose (50 percent kill): 289 mg/kg N/R MUREAV 223,399,1989
oral
rat
lethal dose (50 percent kill): 157 mg/kg Olfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea
ESKGA2 37,258,1991
subcutaneous
mouse
lowest published toxic dose: 80 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 204,9,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 320 mg/kg/4 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,1184,2008
oral
mouse
lowest published toxic dose: 336 mg/kg/14 day- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ESKGA2 37,266,1991
oral
mouse
lowest published toxic dose: 728 mg/kg/0.5 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,152,2001
oral
rat
lowest published toxic dose: 1,260 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
EVHPAZ 87,309,1990
oral
rat
lowest published toxic dose: 28,000 mg/kg/100 week- continuous Kidney, Ureter, and Bladder: Kidney tumors TXCYAC 221,158,2006
oral
rat
lowest published toxic dose: 14,000 mg/kg/100 week- continuous Endocrine: Thyroid tumors TXCYAC 221,158,2006
oral
rat
lowest published toxic dose: 7,000 mg/kg/100 week- continuous Gastrointestinal: Tumors TXCYAC 221,158,2006
oral
rat
lowest published toxic dose: 1,400 mg/kg/100 week- continuous Gastrointestinal: Other changes

Endocrine: Other changes
TXCYAC 221,158,2006
oral
rat
lowest published toxic dose: 1.4 mg/kg/2 week- continuous Kidney, Ureter, and Bladder: Other changes TXCYAC 221,158,2006
subcutaneous
guinea pig
lowest published toxic dose: 280 mg/kg/14 day- intermittent Ear: Changes in vestibular functions

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001
subcutaneous
guinea pig
lowest published toxic dose: 280 mg/kg/14 day- intermittent Behavioral: Change in psychophysiological tests TXAPA9 177,103,2001
subcutaneous
guinea pig
lowest published toxic dose: 700 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 40,207,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,481,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 40,207,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,481,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,481,1999
TOXICOLOGY REVIEW
MUTAEX 15,431,2000
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
TXCYAC 221,190,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 636,242,2007
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81949;
Number of Industries 6;
Total Number of Facilities 132;
Number of Occupations 9;
Total Number of Employees Exposed 3,252
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81949;
Number of Industries 10;
Total Number of Facilities 1,458;
Number of Occupations 24;
Total Number of Employees Exposed 26,562;
Total Number of Female Employees Exposed 11,090


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor and packaging material
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NPRNAY Nephron. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1964-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a food and feed additive, flavor and packaging material

NIOSH PROFILE (HAIRDRESSING and BARBERS), SRC, 6/80

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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