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Boric acid

RTECS #: ED4550000

CAS #: 10043-35-3


UPDATE: May 2009 MW: 61.84 MF: BH3O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Basilit B
  2. Boracic acid
  3. Borofax
  4. Boron trihydroxide
  5. Borsaure (German)
  6. Dr.'s 1 Flea Terminator DF
  7. Dr.'s 1 Flea Terminator DFPBO
  8. Dr.'s 1 Flea Terminator DT
  1. Dr.'s 1 Flea Terminator DTPBO
  2. Flea Prufe
  3. NCI - C56417
  4. Orthoboric acid
  5. Super Flea Eliminator
  6. Three elephant
  7. Trihydroxyborone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
human
15 mg/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 17,000 ppm/24 hour (-enzymatic activation step) AMNTA4 85,119,1951


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 9,600 g/m3/4 hour (16 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
GTPZAB 16(11),13,1972
intraperitoneal
mouse
lowest published toxic dose: 1,000 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 220,178,2007
oral
mammal (species unspecified)
lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TOXID9 60,222,2001
oral
mouse
lowest published toxic dose: 7,684 mg/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 18,266,1992
oral
mouse
lowest published toxic dose: 17,051 mg/kg (1-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 18,266,1992
oral
mouse
lowest published toxic dose: 18,054 mg/kg (1-18 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
EVHPAZ 102(Suppl 7),107,1994
oral
mouse
lowest published toxic dose: 8,136 mg/kg (1-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
EVHPAZ 102(Suppl 7),107,1994
oral
mouse
lowest published toxic dose: 800 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 51,181,1995
oral
mouse
lowest published toxic dose: 136,080 mg/kg (multigeneration) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOXID9 9,226,1989
oral
mouse
lowest published toxic dose: 9,492 mg/kg (0-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
mouse
lowest published toxic dose: 21.063 gm/kg (0-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HBPTO* 2,1431,2001
oral
mouse
lowest published toxic dose: 22.26 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 93.5 gm/kg (21 week male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 93.5 gm/kg (15 week prior to copulation-3 week after birth) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 152 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 152 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 152 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system REPTED 16,237,2002
oral
mouse
lowest published toxic dose: 800 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 16,237,2002
oral
mouse
lowest published toxic dose: 2,400 mg/kg (6-8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system REPTED 16,237,2002
oral
mouse
lowest published toxic dose: 1,500 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 16,237,2002
oral
mouse
lowest published toxic dose: 750 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system REPTED 16,237,2002
oral
mouse
lowest published toxic dose: 1,500 mg/kg (6-8 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 60,222,2001
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-10 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 60,222,2001
oral
rat
lowest published toxic dose: 1,600 mg/kg (6-9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BTERDG 66,373,1998
oral
rat
lowest published toxic dose: 6,600 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
FAATDF 18,266,1992
oral
rat
lowest published toxic dose: 45 gm/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 5,390 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 18,266,1992
oral
rat
lowest published toxic dose: 1,596 mg/kg (0-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 32,179,1996
oral
rat
lowest published toxic dose: 52 mg/kg (26 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) EVHPAZ 13,69,1976
oral
rat
lowest published toxic dose: 1,716 mg/kg (0-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 2,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 5,000 mg/kg (5-9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 5,000 mg/kg (6-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 1,000 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 1,000 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 76 mg/kg (20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1432,2001
oral
rat
lowest published toxic dose: 7,684 mg/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB91-132332
oral
rat
lowest published toxic dose: 17.1 gm/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB91-132332
oral
rat
lowest published toxic dose: 1,560 mg/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 3,260 mg/kg (1-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 5,390 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 2,990 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Other neonatal measures or effects
NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 2,990 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 2,830 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Physical NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 3,680 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 5,490 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 2,196 mg/kg (14-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB95-137485
oral
rat
lowest published toxic dose: 4,312 mg/kg (14-17 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Physical
NTIS** #PB95-137485
oral
rat
lowest published toxic dose: 6,468 mg/kg (14-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system
NTIS** #PB95-137485
oral
rat
lowest published toxic dose: 750 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 74,268,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (10 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BDERB* 74,268,2005
oral
rat
lowest published toxic dose: 250 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TSPLC* -,227,2003
oral
rabbit
lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TOXID9 12,103,1992
oral
rabbit
lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
FAATDF 34,176,1996
oral
rabbit
lowest published toxic dose: 3,500 mg/kg (7-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 102(Suppl 7),107,1994
oral
rabbit
lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
NTIS** PB92-129550
oral
rabbit
lowest published toxic dose: 1,750 mg/kg (7-20 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female
EVHPAZ 102(Suppl 7),107,1994
oral
rabbit
lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
HBPTO* 2,1431,2001
oral
rabbit
lowest published toxic dose: 875 mg/kg (6-19 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina NTIS** #PB92-129550
oral
rabbit
lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NTIS** #PB92-129550


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 28 mg/m3/4 hour N/R VCVN1* -,193,1988
intraperitoneal
mouse
lowest published lethal dose: 800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
14KTAK -,693,1964
intravenous
mouse
lethal dose (50 percent kill): 1,240 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
JPETAB 134,117,1961
intravenous
mouse
lethal dose (50 percent kill): 1,780 mg/kg N/R HBPTO* 2,1413,2001
intravenous
rat
lethal dose (50 percent kill): 1,330 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
intravenous
rat
lethal dose (50 percent kill): 1,330 mg/kg N/R HBPTO* 2,1413,2001
intravenous
rabbit
lowest published lethal dose: 800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
14KTAK -,693,1964
oral
child
lowest published toxic dose: 500 mg/kg Gastrointestinal: Nausea or vomiting JTCTDW 24,269,1986
oral
child
lowest published lethal dose: 250 mg/kg N/R HBPTO* 2,1414,2001
oral
dog
lowest published lethal dose: 1,780 mg/kg Brain and Coverings: Meningeal changes

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting
JAMAAP 128,266,1945
oral
guinea pig
lowest published lethal dose: 1 gm/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
RAMAAB 46,1493,1932
oral
human
lowest published lethal dose: 214.28 mg/kg N/R HBPTO* 2,1414,2001
oral
infant
lowest published toxic dose: 800 mg/kg/4 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
ADCHAK 58,737,1983
oral
infant
lowest published lethal dose: 400 mg/kg N/R HBPTO* 2,1414,2001
oral
man
lowest published lethal dose: 429 mg/kg Cardiac: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTCTDW 31,345,1993
oral
man
lowest published toxic dose: 1.07 gm/kg Behavioral: Toxic psychosis

Gastrointestinal: Nausea or vomiting
AJKDDP 48,E95,2006
oral
mouse
lethal dose (50 percent kill): 3,450 mg/kg N/R HBPTO* 2,1413,2001
oral
rat
lowest published toxic dose: 2,000 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 6,491,1992
oral
rat
lethal dose (50 percent kill): 2,660 mg/kg N/R HBPTO* 2,1413,2001
oral
rat
lethal dose (50 percent kill): 2,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
HBPTO* 2,1430,2001
oral
rat
lowest published lethal dose: 3,000 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVN1* -,195,1988
oral
rabbit
lowest published lethal dose: 4 gm/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
oral
woman
lowest published toxic dose: 400 mg/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes

Skin: After systemic exposure: Dermatitis, other
YAKUD5 32,804,1990
oral
woman
lowest published lethal dose: 200 mg/kg Behavioral: Fluid intake

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
LANCAO 2,162,1917
parenteral
dog
lowest published lethal dose: 1 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) RTPCAT 1,472,1929
parenteral
rabbit
lowest published lethal dose: 670 mg/kg Nutritional and Gross Metabolic: Body temperature decrease RTPCAT 1,472,1929
subcutaneous
dog
lowest published lethal dose: 1 gm/kg Brain and Coverings: Meningeal changes

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting
JAMAAP 128,266,1945
subcutaneous
guinea pig
lethal dose (50 percent kill): 1,200 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
subcutaneous
infant
lowest published lethal dose: 1,100 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
subcutaneous
mouse
lethal dose (50 percent kill): 1,740 mg/kg N/R JAMAAP 128,266,1945
subcutaneous
rat
lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
14KTAK -,693,1964
subcutaneous
rabbit
lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1289,1935
skin
child
lowest published lethal dose: 4 gm/kg/4 day N/R MMWOAU 52,763,1905
skin
child
lowest published lethal dose: 1,500 mg/kg Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
QJPPAL 6,714,1933
skin
infant
lowest published lethal dose: 1,200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Body temperature increase
JAMAAP 129,332,1945
skin
man
lowest published lethal dose: 2,430 mg/kg Gastrointestinal: Hypermotility, diarrhea

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Body temperature increase
JAMAAP 128,266,1945
unreported route
man
lowest published toxic dose: 170 mg/kg Behavioral: Wakefulness

Behavioral: Anorexia (human)

Gastrointestinal: Nausea or vomiting
RTPCAT 1,472,1929
unreported route
man
lowest published lethal dose: 147 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 10 mg/m3/10 year- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VCVN1* -,196,1988
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,195,1988
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Maternal effects: Ovaries, fallopian tubes
VCVN1* -,195,1988
oral
dog
lowest published toxic dose: 23 gm/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral
infant
lowest published toxic dose: 2,744 mg/kg/4 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1433,2001
oral
mouse
lowest published toxic dose: 42 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-324,1987
oral
mouse
lowest published toxic dose: 156 gm/kg/13 week- intermittent Gastrointestinal: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-324,1987
oral
mouse
lowest published toxic dose: 5,208 mg/kg/21 day- continuous Kidney, Ureter, and Bladder: Other changes HBPTO* 2,1431,2001
oral
mouse
lowest published toxic dose: 238,518 mg/kg/27 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 120,204 mg/kg/27 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight
NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 120,204 mg/kg/27 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 28,728 mg/kg/27 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** #PB90253808
oral
mouse
lowest published toxic dose: 17,051 mg/kg/17 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB91-132332
oral
mouse
lowest published toxic dose: 15,045 mg/kg/15 day- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB91-132332
oral
mouse
lowest published toxic dose: 7,684 mg/kg/17 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTIS** #PB91-132332
oral
mouse
lowest published toxic dose: 147.9 mg/kg/87 day- intermittent Tumorigenic: Protects against induction of experimental tumors TOPADD 32,73,2004
oral
rat
lowest published toxic dose: 45 gm/kg/90 day- continuous Brain and Coverings: Changes in brain weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 68 mg/kg/9 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P
FAATDF 35,205,1997
oral
rat
lowest published toxic dose: 2,160 mg/kg/4 day- continuous Endocrine: Androgenic

Blood: Other changes
TXAPA9 107,325,1991
oral
rat
lowest published toxic dose: 3,780 mg/kg/7 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 107,325,1991
oral
rat
lowest published toxic dose: 15,120 mg/kg/28 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 107,325,1991
oral
rat
lowest published toxic dose: 15.12 gm/kg/4 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 11.34 gm/kg/9 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct HBPTO* 2,1431,2001
oral
rat
lowest published toxic dose: 24,000 mg/kg/30 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,195,1988
oral
rat
lowest published toxic dose: 7,000 mg/kg/2 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTSCDR 25,223,2000
oral
rat
lowest published toxic dose: 4,200 mg/kg/2 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct JTSCDR 25,233,2000
oral
rat
lowest published toxic dose: 1,956 mg/kg/12 day- continuous Behavioral: Food intake (animal) NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 3,260 mg/kg/20 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 5,940 mg/kg/18 day- continuous Behavioral: Fluid intake NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 6,600 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB91-137588
oral
rat
lowest published toxic dose: 2,990 mg/kg/10 day- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 4,340 mg/kg/10 day- continuous Liver: Changes in liver weight NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 3,610 mg/kg/10 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB95-149399
oral
rat
lowest published toxic dose: 1,617 mg/kg/1 day- continuous Behavioral: Fluid intake NTIS** #PB95-137485
oral
rat
lowest published toxic dose: 4,312 mg/kg/4 day- continuous Liver: Changes in liver weight NTIS** #PB95-137485
oral
rat
lowest published toxic dose: 4,000 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight CTOXAO 44,249,2006
oral
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) CTOXAO 44,249,2006
oral
rabbit
lowest published toxic dose: 6,000 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,194,1988
oral
rabbit
lowest published toxic dose: 15,000 mg/kg/15 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,194,1988
oral
rabbit
lowest published toxic dose: 15,000 mg/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,194,1988
oral
rabbit
lowest published toxic dose: 14,700 mg/kg/12 week- intermittent Blood: Luekopenia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
VCVN1* -,195,1988
oral
rabbit
lowest published toxic dose: 1,750 mg/kg/14 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB92-129550
oral
rabbit
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB92-129550


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3;short term exposure limit 6 mg/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
FNSCA6 2,67,1973
TOXICOLOGY REVIEW
JOPDAB 61,531,1962
TOXICOLOGY REVIEW
JTSCDR 25,1,2000
TOXICOLOGY REVIEW
TOLED5 135,167,2002
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
ENTOX* -,329,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,91,1998
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3, short term exposure limit 6 mg/m3, MAR2002
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7080;
Number of Industries 187;
Total Number of Facilities 27,071;
Number of Occupations 128;
Total Number of Employees Exposed 489,668;
Total Number of Female Employees Exposed 211,838
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8324;
Number of Industries 3;
Total Number of Facilities 84;
Number of Occupations 4;
Total Number of Employees Exposed 2,919;
Total Number of Female Employees Exposed 1,712


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, cosmetic and perfume ingredient, pharmaceutical
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926-
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981-
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867-
BDERB*
BTERDG Biological Trace Element Research. (Humana Press Inc., POB 2148, Clifton, NJ 07015) V.1- 1979-
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MDSR** U.S. Army, Chemical Corps Medical Division Special Report. (Army Chemical Center, MD)
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RTPCAT Rassegna di Terapia e Patologia Clinica. (Rome, Italy) V.1-8, 1929-36. For publisher information, see RFCTAJ.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TSPLC*
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as a chemical intermediate, cosmetic and perfume ingredient, pharmaceutical

NIOSH PROFILE (BORON and ITS COMPOUNDS), SRC, 10/77

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 12795-04-9
Click Here for Additional Information about RTECS

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