Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Boric acid

RTECS #

ED4550000

CAS #

10043-35-3; 12795-04-9

Updated

September 201

Molecular Weight

61.84

Molecular Formula

BH3O3

Synonyms

Basilit B
Boracic acid
Borofax
Boron trihydroxide
Borsaure (German)
Dr.'s 1 Flea Terminator DF
Dr.'s 1 Flea Terminator DFPBO
Dr.'s 1 Flea Terminator DT
Dr.'s 1 Flea Terminator DTPBO
Flea Prufe
NCI-C56417
Orthoboric acid
Super Flea Eliminator
Three elephant
Trihydroxyborone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 15 mg/3D- intermittent mild85DKA8 -,127,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli17000 ppm/24H (-enzymatic activation step)AMNTA4 85,119,1951

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 9600 µg/m3/4H (16W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
GTPZAB 16(11),13,1972
intraperitoneal/mouse 1000 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 220,178,2007
oral/rat 750 mg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 74,268,2005
oral/rat 1000 mg/kg (10D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)BDERB* 74,268,2005
oral/rat 250 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTSPLC* -,227,2003
oral/rat 600 mg/kg (6-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 86,214,2009
oral/rat 3000 mg/kg (6-11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 86,214,2009
oral/rat 1600 mg/kg (6-9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemBTERDG 66,373,1998
oral/rat 6600 mg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
FAATDF 18,266,1992
oral/rat 45 gm/kg (90D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 23,351,1972
oral/rat 5390 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 18,266,1992
oral/rat 1596 mg/kg (0-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 32,179,1996
oral/rat 52 mg/kg (26W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)EVHPAZ 13,69,1976
oral/mouse 7684 mg/kg (1-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 18,266,1992
oral/mouse 17051 mg/kg (1-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 18,266,1992
oral/mouse 18054 mg/kg (1-18D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
EVHPAZ 102(Suppl 7),107,1994
oral/mouse 8136 mg/kg (1-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
EVHPAZ 102(Suppl 7),107,1994
oral/mouse 800 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 51,181,1995
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TOXID9 12,103,1992
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
FAATDF 34,176,1996
oral/rabbit 3500 mg/kg (7-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 102(Suppl 7),107,1994
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
NTIS** PB92-129550
oral/rabbit 1750 mg/kg (7-20D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female
EVHPAZ 102(Suppl 7),107,1994
oral/mouse 136080 mg/kg (multigeneration)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOXID9 9,226,1989
oral/mouse 9492 mg/kg (0-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/mouse 21.063 gm/kg (0-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HBPTO* 2,1431,2001
oral/rat 1716 mg/kg (0-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/rat 2000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
HBPTO* 2,1431,2001
oral/rat 5000 mg/kg (5-9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/rat 5000 mg/kg (6-10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/rat 1000 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/rat 1000 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1431,2001
oral/rat 76 mg/kg (20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1432,2001
oral/mouse 22.26 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB90253808
oral/mouse 93.5 gm/kg (21W male)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
NTIS** #PB90253808
oral/mouse 93.5 gm/kg (15W pre-3W after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB90253808
oral/mouse 152 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB90253808
oral/mouse 152 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB90253808
oral/mouse 152 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB90253808
oral/rabbit 875 mg/kg (6-19D pregnant)Reproductive: Maternal effects: Uterus, cervix, vaginaNTIS** #PB92-129550
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NTIS** #PB92-129550
oral/rat 7684 mg/kg (1-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB91-132332
oral/rat 17.1 gm/kg (1-17D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB91-132332
oral/rat 1560 mg/kg (1-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB91-137588
oral/rat 3260 mg/kg (1-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemNTIS** #PB91-137588
oral/rat 5390 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** #PB91-137588
oral/rat 2990 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Other neonatal measures or effects
NTIS** #PB95-149399
oral/rat 2990 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemNTIS** #PB95-149399
oral/rat 2830 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: PhysicalNTIS** #PB95-149399
oral/rat 3680 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)NTIS** #PB95-149399
oral/rat 5490 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)NTIS** #PB95-149399
oral/rat 2196 mg/kg (14-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB95-137485
oral/rat 4312 mg/kg (14-17D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Physical
NTIS** #PB95-137485
oral/rat 6468 mg/kg (14-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system
NTIS** #PB95-137485
oral/mouse 2500 mg/kg (6-10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemREPTED 16,237,2002
oral/mouse 800 mg/kg (7D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 16,237,2002
oral/mouse 2400 mg/kg (6-8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemREPTED 16,237,2002
oral/mouse 1500 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 16,237,2002
oral/mouse 750 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemREPTED 16,237,2002
oral/mammal (species unspecified) 500 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTOXID9 60,222,2001
oral/mouse 1500 mg/kg (6-8D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOXID9 60,222,2001
oral/mouse 2500 mg/kg (6-10D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOXID9 60,222,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 131 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/rat Lowest published lethal concentration: 28 mg/m3/4HVCVN1* -,193,1988
intraperitoneal/mouse lowest published lethal dose: 800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
14KTAK -,693,1964
intravenous/mouse lethal dose (50 percent kill): 1780 mg/kgHBPTO* 2,1413,2001
intravenous/mouse lethal dose (50 percent kill): 1240 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
JPETAB 134,117,1961
intravenous/rabbit lowest published lethal dose: 800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
14KTAK -,693,1964
intravenous/rat lethal dose (50 percent kill): 1330 mg/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
intravenous/rat lethal dose (50 percent kill): 1330 mg/kgHBPTO* 2,1413,2001
oral/child lowest published lethal dose: 250 mg/kgHBPTO* 2,1414,2001
oral/child lowest published toxic dose: 500 mg/kgGastrointestinal: Nausea or vomitingJTCTDW 24,269,1986
oral/Dog lowest published lethal dose: 1780 mg/kgBrain and Coverings: Meningeal changes

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting
JAMAAP 128,266,1945
oral/guinea pig lowest published lethal dose: 1 gm/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
RAMAAB 46,1493,1932
oral/human lowest published lethal dose: 214.28 mg/kgHBPTO* 2,1414,2001
oral/infant lowest published lethal dose: 400 mg/kgHBPTO* 2,1414,2001
oral/infant lowest published toxic dose: 800 mg/kg/4W- intermittentBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
ADCHAK 58,737,1983
oral/man lowest published toxic dose: 1.07 gm/kgBehavioral: Toxic psychosis

Gastrointestinal: Nausea or vomiting
AJKDDP 48,E95,2006
oral/man lowest published lethal dose: 429 mg/kgCardiac: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTCTDW 31,345,1993
oral/mouse lethal dose (50 percent kill): 3450 mg/kgHBPTO* 2,1413,2001
oral/rabbit lowest published lethal dose: 4 gm/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
oral/rat lowest published toxic dose: 2000 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 6,491,1992
oral/rat lethal dose (50 percent kill): 2660 mg/kgHBPTO* 2,1413,2001
oral/rat lethal dose (50 percent kill): 2500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
HBPTO* 2,1430,2001
oral/rat lowest published lethal dose: 3000 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductVCVN1* -,195,1988
oral/woman lowest published toxic dose: 400 mg/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes

Skin: After systemic exposure: Dermatitis, other
YAKUD5 32,804,1990
oral/woman lowest published lethal dose: 200 mg/kgBehavioral: Fluid intake

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
LANCAO 2,162,1917
parenteral/Dog lowest published lethal dose: 1 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)RTPCAT 1,472,1929
parenteral/rabbit lowest published lethal dose: 670 mg/kgNutritional and Gross Metabolic: Body temperature decreaseRTPCAT 1,472,1929
skin/child lowest published lethal dose: 4 gm/kg/4DMMWOAU 52,763,1905
skin/child lowest published lethal dose: 1500 mg/kgEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
QJPPAL 6,714,1933
skin/infant lowest published lethal dose: 1200 mg/kgBehavioral: Convulsions or effect on seizure threshold

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Body temperature increase
JAMAAP 129,332,1945
skin/man lowest published lethal dose: 2430 mg/kgGastrointestinal: Hypermotility, diarrhea

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Body temperature increase
JAMAAP 128,266,1945
subcutaneous/Dog lowest published lethal dose: 1 gm/kgBrain and Coverings: Meningeal changes

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting
JAMAAP 128,266,1945
subcutaneous/guinea pig lethal dose (50 percent kill): 1200 mg/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
subcutaneous/infant lowest published lethal dose: 1100 mg/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
MDSR** #2,1950
subcutaneous/mouse lethal dose (50 percent kill): 1740 mg/kgJAMAAP 128,266,1945
subcutaneous/rabbit lowest published lethal dose: 150 mg/kgHBAMAK 4,1289,1935
subcutaneous/rat lethal dose (50 percent kill): 1400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
14KTAK -,693,1964
Tank with water/Zebrafish lowest published toxic concentration: 5.85 mmol/L 144HEye: Other eye effects

Ear: Tumors
REPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 5.85 mmol/L 144HCardiac: Arrythmias (indlucing changes in conduction)

Blood: Other changes

Musculoskeletal: Other changes
REPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 5.85 mmol/L 144HSkin and Appendages: Other glandsREPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 25.24 mmol/L 48HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 42.20 mmol/L 72HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 23.55 mmol/L 144HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
unreported route/man lowest published toxic dose: 170 mg/kgBehavioral: Wakefulness

Behavioral: Anorexia (human)

Gastrointestinal: Nausea or vomiting
RTPCAT 1,472,1929
unreported route/man lowest published lethal dose: 147 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/man lowest published toxic concentration: 10 mg/m3/10Y- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)VCVN1* -,196,1988
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/16W- intermittentLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,195,1988
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/16W- intermittentLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Maternal effects: Ovaries, fallopian tubes
VCVN1* -,195,1988
oral/Dog lowest published toxic dose: 23 gm/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral/infant lowest published toxic dose: 2744 mg/kg/4W- intermittentBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1433,2001
oral/mouse lowest published toxic dose: 42 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-324,1987
oral/mouse lowest published toxic dose: 156 gm/kg/13W- intermittentGastrointestinal: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-324,1987
oral/mouse lowest published toxic dose: 238518 mg/kg/27W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB90253808
oral/mouse lowest published toxic dose: 120204 mg/kg/27W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight
NTIS** #PB90253808
oral/mouse lowest published toxic dose: 120204 mg/kg/27W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
NTIS** #PB90253808
oral/mouse lowest published toxic dose: 28728 mg/kg/27W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** #PB90253808
oral/mouse lowest published toxic dose: 5208 mg/kg/21D- continuousKidney, Ureter, and Bladder: Other changesHBPTO* 2,1431,2001
oral/mouse lowest published toxic dose: 147.9 mg/kg/87D- intermittentTumorigenic: Protects against induction of experimental tumorsTOPADD 32,73,2004
oral/mouse lowest published toxic dose: 17051 mg/kg/17D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB91-132332
oral/mouse lowest published toxic dose: 15045 mg/kg/15D- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB91-132332
oral/mouse lowest published toxic dose: 7684 mg/kg/17D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)NTIS** #PB91-132332
oral/rabbit lowest published toxic dose: 1750 mg/kg/14D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB92-129550
oral/rabbit lowest published toxic dose: 3500 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightNTIS** #PB92-129550
oral/rabbit lowest published toxic dose: 6000 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN1* -,194,1988
oral/rabbit lowest published toxic dose: 15000 mg/kg/15D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN1* -,194,1988
oral/rabbit lowest published toxic dose: 15000 mg/kg/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN1* -,194,1988
oral/rabbit lowest published toxic dose: 14700 mg/kg/12W- intermittentBlood: Luekopenia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
VCVN1* -,195,1988
oral/rat lowest published toxic dose: 24000 mg/kg/30D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,195,1988
oral/rat lowest published toxic dose: 45 gm/kg/90D- continuousBrain and Coverings: Changes in brain weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral/rat lowest published toxic dose: 68 mg/kg/9W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P
FAATDF 35,205,1997
oral/rat lowest published toxic dose: 2160 mg/kg/4D- continuousEndocrine: Androgenic

Blood: Other changes
TXAPA9 107,325,1991
oral/rat lowest published toxic dose: 3780 mg/kg/7D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 107,325,1991
oral/rat lowest published toxic dose: 15120 mg/kg/28D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 107,325,1991
oral/rat lowest published toxic dose: 15.12 gm/kg/4W- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductHBPTO* 2,1431,2001
oral/rat lowest published toxic dose: 11.34 gm/kg/9W- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductHBPTO* 2,1431,2001
oral/rat lowest published toxic dose: 7000 mg/kg/2W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTSCDR 25,223,2000
oral/rat lowest published toxic dose: 4200 mg/kg/2W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductJTSCDR 25,233,2000
oral/rat lowest published toxic dose: 1956 mg/kg/12D- continuousBehavioral: Food intake (animal)NTIS** #PB91-137588
oral/rat lowest published toxic dose: 3260 mg/kg/20D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB91-137588
oral/rat lowest published toxic dose: 5940 mg/kg/18D- continuousBehavioral: Fluid intakeNTIS** #PB91-137588
oral/rat lowest published toxic dose: 6600 mg/kg/20D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB91-137588
oral/rat lowest published toxic dose: 2990 mg/kg/10D- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB95-149399
oral/rat lowest published toxic dose: 4340 mg/kg/10D- continuousLiver: Changes in liver weightNTIS** #PB95-149399
oral/rat lowest published toxic dose: 3610 mg/kg/10D- continuousKidney, Ureter, and Bladder: Changes in kidney weightNTIS** #PB95-149399
oral/rat lowest published toxic dose: 1617 mg/kg/1D- continuousBehavioral: Fluid intakeNTIS** #PB95-137485
oral/rat lowest published toxic dose: 4312 mg/kg/4D- continuousLiver: Changes in liver weightNTIS** #PB95-137485
oral/rat lowest published toxic dose: 4000 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJTCTDW 44,249,2006
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)JTCTDW 44,249,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3;short term exposure limit 6 mg/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWJOPDAB 61,531,1962
TOXICOLOGY REVIEWJTSCDR 25,1,2000
TOXICOLOGY REVIEWTOLED5 135,167,2002
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWENTOX* -,329,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWHTOPA* 1,501,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,91,1998
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg/m3, short term exposure limit 6 mg/m3, MAR2002
Occupational Exposure Limit-GERMANYMAK 10 mg/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 10 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7080; Number of Industries 187; Total Number of Facilities 27071; Number of Occupations 128; Total Number of Employees Exposed 489668; Total Number of Female Employees Exposed 211838
National Occupational Exposure Survey 1983Hazard Code X8324; Number of Industries 3; Total Number of Facilities 84; Number of Occupations 4; Total Number of Employees Exposed 2919; Total Number of Female Employees Exposed 1712

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse
On EPA IRIS database
TOP