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Registry of Toxic Effects of Chemical Substances (RTECS)

2,2'-Bipyridine

RTECS #

DW1750000

CAS #

366-18-7

Updated

December 2010

Molecular Weight

156.20

Molecular Formula

C10H8N2

Synonyms

2,2'-Bipyridin
2,2'-Bipyridyl
2,2'-Dipyridyl
alpha,alpha'-Bipyridine
alpha,alpha'-Bipyridyl
alpha,alpha'-Dipyridyl
alpha,alpha'-Dwupirydylu (Polish)
Bipyridine
CI-588

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelung/hamster12500 µg/LMUREAV 300,223,1993
mutation in mammalian somatic cellslung/hamster14500 µg/LMUREAV 300,223,1993
mutation in microorganisms/Salmonella typhimurium20 µg/plate (+/-enzymatic activation step)ABCHA6 45,327,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 60 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 18,63,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 8000 mg/kg/40W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
JNCIAM 24,109,1960

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
JPETAB 196,478,1976
intraperitoneal/rat lethal dose (50 percent kill): 150 mg/kgPJPPAA 27,619,1975
oral/mouse lethal dose (50 percent kill): 330 mg/kgUSXXAM #3875163
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Muscle weakness

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Hemorrhage
JTEHD6 10,363,1982
subcutaneous/rat lethal dose (50 percent kill): 131 mg/kgJPETAB 135,317,1962

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTXB2 34,447,2004
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 5,1,1981

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84441; Number of Industries 6; Total Number of Facilities 461; Number of Occupations 7; Total Number of Employees Exposed 3684; Total Number of Female Employees Exposed 886
National Occupational Hazard Survey 1974Hazard Code 84441; Number of Industries 3; Total Number of Facilities 141; Number of Occupations 3; Total Number of Employees Exposed 708

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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