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3,3'4,4' - Biphenyltetramine

RTECS #: DV8750000

CAS #: 91-95-2


UPDATE: February 2008 MW: 214.30 MF: C12H14N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (1,1' - Biphenyl) - 3,3',4,4' - tetramine (9CI)
  2. 3,3',4,4' - Diphenyltetramine
  3. 3,3',4,4' - Tetraaminobiphenyl
  1. 3,3',4,4' - Tetraaminodiphenyl
  2. 3,3' - Diaminobenzidene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse
100 mg/kg MUREAV 319,19,1993
DNA adduct Escherichia coli 20 µmol/L MUREAV 89,95,1981
DNA damage human lymphocyte 100 µmol/L/2 hour TOSCF2 72,283,2003
unscheduled DNA synthesis rat liver 500 µmol/L ENMUDM 3,11,1981
mutation in microorganisms Salmonella typhimurium 25 µg/plate (-enzymatic activation step) MUREAV 158,19,1985
mutation in microorganisms Salmonella typhimurium 3 µg/plate (+enzymatic activation step) TOSCF2 56,351,2000
mutation in microorganisms Saccharomyes cerevisiae 140 µmol/L (-enzymatic activation step) MGGEAE 174,39,1979
other mutation test systems intraperitoneal
mouse
100 mg/kg MUREAV 319,19,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 9,000 mg/kg/27 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 28,924,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 260 mg/m3/4 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0537196
oral
mouse
lethal dose (50 percent kill): 1,834 mg/kg N/R GISAAA 46(1),94,1981
oral
rat
lowest published lethal dose: 3 gm/kg N/R CNREA8 26,619,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEW
MUREAV 612,58,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWITZERLAND MAK- week 0.003 ppm (0.03 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5448;
Number of Industries 1;
Total Number of Facilities 38;
Number of Occupations 2;
Total Number of Employees Exposed 135;
Total Number of Female Employees Exposed 95


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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