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Registry of Toxic Effects of Chemical Substances (RTECS)

3,3'4,4'-Biphenyltetramine

RTECS #

DV8750000

CAS #

91-95-2

Updated

July 2013

Molecular Weight

214.30

Molecular Formula

C12H14N4

Synonyms

(1,1'-Biphenyl)-3,3',4,4'-tetramine (9CI)
3,3',4,4'-Diphenyltetramine
3,3',4,4'-Tetraaminobiphenyl
3,3',4,4'-Tetraaminodiphenyl
3,3'-Diaminobenzidene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse100 mg/kgMUREAV 319,19,1993
DNA adduct/Escherichia coli20 µmol/LMUREAV 89,95,1981
DNA Damagelymphocyte/human100 µmol/L/2HTOSCF2 72,283,2003
mutation in microorganisms/Salmonella typhimurium3 µg/plate (+enzymatic activation step)TOSCF2 56,351,2000
mutation in microorganisms/Saccharomyes cerevisiae140 µmol/L (-enzymatic activation step)MGGEAE 174,39,1979
mutation in microorganisms/Salmonella typhimurium25 µg/plate (-enzymatic activation step)MUREAV 158,19,1985
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 319,19,1993
Unscheduled DNA Synthesisliver/rat500 µmol/LENMUDM 3,11,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 9000 mg/kg/27D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 28,924,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 260 mg/m3/4HBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0537196
oral/mouse lethal dose (50 percent kill): 1834 mg/kgGISAAA 46(1),94,1981
oral/rat lowest published lethal dose: 3 gm/kgCNREA8 26,619,1966

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEWMUREAV 612,58,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.003 ppm (0.03 mg/m3);KZW 0.012 ppm (0.12 mg/m3), inhal, skin, 2007
Occupational Exposure Limit-SWITZERLANDMAK-week 0.003 ppm (0.03 mg/m3), JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5448; Number of Industries 1; Total Number of Facilities 38; Number of Occupations 2; Total Number of Employees Exposed 135; Total Number of Female Employees Exposed 95

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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