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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Biphenylol

RTECS #

DV5775000

CAS #

90-43-7

Updated

July 2011

Molecular Weight

170.22

Molecular Formula

C12H10O

Synonyms

(1,1'-Biphenyl)-2-ol
2-Fenylfenol (Czech)
2-Hydroxybifenyl (Czech)
2-Hydroxybiphenyl
2-Hydroxydiphenyl
2-Phenylphenol
Biphenyl, 2-hydroxy-
Dowicide 1
Dowicide 1 antimicrobial
Invalon OP
NCI-C50351
Nectryl
o-Biphenylol
o-Diphenylol
o-Hydroxybiphenyl
o-Hydroxydiphenyl
o-Phenylphenol
Orthohydroxydiphenyl
Orthophenylphenol
Orthoxenol
o-Xenol
Phenol, o-phenyl-
Preventol O Extra
Remol TRF
Tetrosin OE
Torsite
Tumescal OPE
USAF EK-2219

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe85JCAE -,228,1986
skin /human 0.5%/76H mildCRTXB2 32,551,2002
skin /rabbit 250 mgMccSB# 15JUN1984
skin /rabbit 20 mg/24H moderate85JCAE -,228,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/human200 µg/LMUREAV 54,255,1978
Cytogenetic Analysisovary/hamster100 mg/LMUREAV 141,95,1984
Cytogenetic Analysis/Saccharomyes cerevisiae0.25 mmol/L/17HMUREAV 617,90,2007
DNA Damageoral/mouse2 gm/kgMUREAV 395,189,1997
DNA repair/Escherichia coli1 mg/discCMSHAF 10,223,1981
micronucleus testoral/rat2 pph/14DMUTAEX 17,89,2002
micronucleus testoral/rat9660 mg/kg/15D-continuousFCTOD7 44,1340,2006
mutation in mammalian somatic cellslymphocyte/mouse50 mg/LNTPTR* NTP-TR-301,1986
mutation in mammalian somatic cellsembryo/human20 mg/LMUREAV 156,123,1985
mutation in mammalian somatic cellsother cell types/human15 mg/LTRENAF 35,399,1984
mutation in microorganisms/Salmonella typhimurium60 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganismslymphocyte/mouse5 mg/L (+enzymatic activation step)NTPTR* NTP-TR-301,1986
sex chromosome loss and nondisjunction/Aspergillus nidulans52 µmol/LEVHPAZ 31,81,1979
sister chromatid exchangeovary/hamster29900 µg/LNTPTR* NTP-TR-301,1986
specific locus test/Escherichia coli1 µmol/L/30MMUREAV 628,123,2007
Unscheduled DNA Synthesisoral/rat336 gm/kg/4W-continuousCALEDQ 48,19,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NNGADV 3,365,1978
oral/rat 52168 mg/kg (13W male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TRENAF 32-2,33,1981
oral/mouse 13050 mg/kg (7-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TRENAF 29,89,1978
oral/mouse 13050 mg/kg (7-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TRENAF 29,89,1978
oral/rabbit 6500 mg/kg (7-19D pregnant)Reproductive: Other effects on femaleNTIS** OTS0544434

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 478 gm/kg/91W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FCTOD7 22,865,1984
oral/rat toxic dose: 478 gm/kg/91W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FCTOD7 22,865,1984
oral/rat toxic dose: 135 gm/kg/26W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FCTOD7 25,359,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >949 mg/m3/1HCRTXB2 32,551,2002
inhalation/rat lethal concentration (50 percent kill): >36 mg/m3/4HCRTXB2 32,551,2002
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgNTIS** AD277-689
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgLiver: Other changesVCVGK* -,218,1994
oral/cat lethal dose (50 percent kill): 500 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage
ANALAO 70,334,1945
oral/cat lethal dose (50 percent kill): 500 mg/kgCRTXB2 32,551,2002
oral/Dog lowest published toxic dose: 100 mg/kgGastrointestinal: Nausea or vomitingCRTXB2 32,551,2002
oral/guinea pig lethal dose (50 percent kill): 3500 mg/kgCRTXB2 32,551,2002
oral/mouse lethal dose (50 percent kill): 1050 mg/kgBehavioral: Ataxia

Cardiac: Other changes

Lung, Thorax, or Respiration: Respiratory depression
NAIZAM 32,425,1981
oral/mouse lowest published toxic dose: 1000 mg/kgSkin and Appendages: Other: HairCRTXB2 32,551,2002
oral/mouse lethal dose (50 percent kill): 1050 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
CRTXB2 32,551,2002
oral/mouse lowest published lethal dose: 1500 mg/kgLiver: Other changesVCVGK* -,218,1994
oral/rat lethal dose (50 percent kill): 2700 mg/kgLiver: Other changesVCVGK* -,218,1994
oral/rat lethal dose (50 percent kill): 2 gm/kgNNGADV 3,365,1978
oral/rat lowest published toxic dose: 2500 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuseCRTXB2 32,551,2002
oral/rat lowest published toxic dose: 1400 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CRTXB2 32,551,2002
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgCRTXB2 32,551,2002
skin/rat lethal dose (50 percent kill): >2000 mg/kgCRTXB2 32,551,2002
subcutaneous/rat lowest published toxic dose: 2500 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuseCRTXB2 32,551,2002
unreported route/rat lethal dose (50 percent kill): 2700 mg/kgTRENAF 29,89,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 31 gm/kg/31D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJPETAB 104,202,1952
oral/mouse lowest published toxic dose: 1752 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainVCVGK* -,220,1994
oral/mouse lowest published toxic dose: 61250 µg/kg/7W- continuousImmunological Including Allergic: Decrease in humoral immune response

Immunological Including Allergic: Decreased immune response
DCTODJ 2,167,1979
oral/mouse lowest published toxic dose: 2 gm/kg/2W- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count
TXAPA9 58,252,1981
oral/mouse lowest published toxic dose: 182.5 gm/kg/2Y- continuousLiver: Other changes

Liver: Changes in liver weight
CRTXB2 32,551,2002
oral/mouse lowest published toxic dose: 365 gm/kg/2Y- continuousLiver: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CRTXB2 32,551,2002
oral/mouse lowest published toxic dose: 182.5 gm/kg/2Y- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CRTXB2 32,551,2002
oral/mouse lowest published toxic dose: 120000 mg/kg/240D- continuousBlood: Change in clotting factors

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JOETD7 111,155,2007
oral/rat lowest published toxic dose: 110.25 gm/kg/21W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainCRTXB2 32,551,2002
oral/rat lowest published toxic dose: 477.75 gm/kg/91W- continuousKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Bladder tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CRTXB2 32,551,2002
oral/rat lowest published toxic dose: 955.5 gm/kg/91W- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Bladder tumors
CRTXB2 32,551,2002
oral/rat lowest published toxic dose: 109.5 gm/kg/1Y- continuousKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CRTXB2 32,551,2002
oral/rat lowest published toxic dose: 175.2 gm/kg/1Y- continuousKidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Bladder tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CRTXB2 32,551,2002
oral/rat lowest published toxic dose: 547.5 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
CRTXB2 32,551,2002
oral/rat lowest published toxic dose: 876 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
YKYUA6 35,779,1984
oral/rat lowest published toxic dose: 728 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
JPETAB 104,202,1952
oral/rat lowest published toxic dose: 46500 mg/kg/31D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 104,202,1952
oral/rat lowest published toxic dose: 4500 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)CRTXB2 32,551,2002
oral/rat lowest published toxic dose: 135 gm/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainCRTXB2 32,551,2002
oral/rat lowest published toxic dose: 170.625 gm/kg/13W- continuousKidney, Ureter, and Bladder: Interstitial nephritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CRTXB2 32,551,2002
skin/mouse lowest published toxic dose: 26640 mg/kg/4W- intermittentSkin: After systemic exposure: Dermatitis, otherNTPTR* NTP-TR-301,1986
skin/rat lowest published toxic dose: 15 gm/kg/21D- intermittentSkin: After topical application: Primary irritationCRTXB2 32,551,2002

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 73,451,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,329,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,329,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,451,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 73,451,1999
TOXICOLOGY REVIEWCRTXB2 32,551,2002
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWEMMUEG 45,460,2005
TOXICOLOGY REVIEWMUREAV 588,129,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUTAEX 20,245,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWCCPHDZ 45,460,2005
TOXICOLOGY REVIEWFEREAC 73,54954,2008
TOXICOLOGY REVIEWMUTAEX 26,223,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,200,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81040; Number of Industries 135; Total Number of Facilities 15646; Number of Occupations 114; Total Number of Employees Exposed 617394; Total Number of Female Employees Exposed 379044
National Occupational Hazard Survey 1974Hazard Code 81040; Number of Industries 67; Total Number of Facilities 7224; Number of Occupations 58; Total Number of Employees Exposed 221003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);no evidence:rat
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