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4',4''' - Biacetanilide

RTECS #: DT2800000

CAS #: 613-35-4


UPDATE: August 2006 MW: 268.34 MF: C16H16N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 4,4' - Diacetamidobiphenyl
  2. 4,4' - Diacetylaminobiphenyl
  3. 4,4' - Diacetylbenzidine
  4. Diacetylbenzidine
  1. N,N' - (1,1' - Biphenyl) - 4,4' - diylbis - acetamide 4',4''' - biacetanilide
  2. N,N' - 4,4' - Biphenylylenebisacetamide
  3. N,N' - Diacetyl benzidine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct rat liver 100 mg/L CRNGDP 5,407,1984
DNA damage oral
mouse
2 gm/kg MUREAV 440,1,1999
mutation in microorganisms Salmonella typhimurium 5 g/plate (-enzymatic activation step) ENMUDM 6,145,1984
micronucleus test intraperitoneal
mouse
100 mg/kg MUREAV 389,3,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 64 mg/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
CRNGDP 2,747,1981
intraperitoneal
rat
toxic dose : 900 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
ARPAAQ 81,146,1966
oral
rat
lowest published toxic dose: 6,300 mg/kg/35 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors
CNREA8 16,525,1956
subcutaneous
rat
lowest published toxic dose: 900 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
ARPAAQ 81,146,1966
subcutaneous
rat
toxic dose : 4,350 mg/kg/39 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VOONAW 8(11),11,1962


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 16,293,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 16,293,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 612,58,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

Used in the preparation of 3,3'-DICHLOROBENZIDINE

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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