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Registry of Toxic Effects of Chemical Substances (RTECS)

4',4'''-Biacetanilide

RTECS #

DT2800000

CAS #

613-35-4

Updated

December 2012

Molecular Weight

268.34

Molecular Formula

C16H16N2O2

Synonyms

4,4'-Diacetamidobiphenyl
4,4'-Diacetylaminobiphenyl
4,4'-Diacetylbenzidine
Diacetylbenzidine
N,N'-(1,1'-Biphenyl)-4,4'-diylbis-acetamide 4',4'''-biacetanilide
N,N'-4,4'-Biphenylylenebisacetamide
N,N'-Diacetyl benzidine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductliver/rat100 mg/LCRNGDP 5,407,1984
DNA Damageoral/mouse2 gm/kgMUREAV 440,1,1999
micronucleus testintraperitoneal/mouse100 mg/kgMUREAV 389,3,1997
mutation in microorganisms/Salmonella typhimurium5 µg/plate (-enzymatic activation step)ENMUDM 6,145,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 64 mg/kg/4W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
CRNGDP 2,747,1981
intraperitoneal/rat toxic dose: 900 mg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
ARPAAQ 81,146,1966
oral/rat lowest published toxic dose: 6300 mg/kg/35W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors
CNREA8 16,525,1956
subcutaneous/rat lowest published toxic dose: 900 mg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
ARPAAQ 81,146,1966
subcutaneous/rat toxic dose: 4350 mg/kg/39W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VOONAW 8(11),11,1962

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 16,293,1978
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 16,293,1978
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 612,58,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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