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Beryllium sulfate (1:1)

RTECS #: DS4800000

CAS #: 13510-49-1


UPDATE: May 2009 MW: 105.07 MF: O4SBe


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Beryllium sulfate (6CI,7CI)
  2. Beryllium sulphate
  1. Sulfuric acid, beryllium salt (1:1)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
910 g/kg/26 week- continuous GISAAA 54(8),73,1989
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
unscheduled DNA synthesis mouse lymphocyte 5 mol/L TOLED5 30,89,1986
unscheduled DNA synthesis mouse other cell types 3 mol/L ARTODN 56,207,1985
morphological transform hamster embryo 560 mol/L CNREA8 39,193,1979
morphological transform mouse fibroblast 200 g/L JJIND8 67,1303,1981
morphological transform rat embryo 60 g/L JJIND8 67,1303,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
monkey
lowest published toxic concentration: 38.8 g/m3/3 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,415,2007
inhalation
monkey
lowest published toxic concentration: 38.8 g/m3/3 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,415,2007
inhalation
rat
lowest published toxic concentration: 432 g/m3/26 week Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PEXTAR 2,203,1961
inhalation
rat
toxic concentration (other than lowest) : 643 g/m3/39 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AMIHAB 19,190,1959
inhalation
rat
lowest published toxic concentration: 0.35 mg/m3 /180 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,415,2007
inhalation
rat
lowest published toxic concentration: 0.35 mg/m3 /180 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,415,2007
inhalation
rat
lowest published toxic dose: 34 g/m3/56 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,177,2007
intraperitoneal
mouse
lowest published toxic dose: 48 mg/kg/8 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
MUREAV 240,217,1990
intratracheal
rat
lowest published toxic dose: 17 mg/kg/2 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AMIHAB 19,190,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 10 mg/m3 N/R EQSSDX 1,1,1975
inhalation
guinea pig
lethal concentration (50 percent kill): 47 mg/m3 N/R EQSSDX 1,1,1975
inhalation
human
lowest published toxic concentration: 0.67 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase
VCVN1* -,95,1988
inhalation
mouse
lowest published lethal concentration: 47 mg/m3 N/R EQSSDX 1,1,1975
inhalation
mouse
lowest published toxic concentration: 4.05 g/m3/1 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
HBTME* -,415,2007
inhalation
rat
lowest published lethal concentration: 10 mg/m3 N/R EQSSDX 1,1,1975
inhalation
rabbit
lowest published lethal concentration: 10 mg/m3 N/R EQSSDX 1,1,1975
intramuscular
rat
lowest published toxic dose: 4.5 mg/kg Vascular: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,93,1988
intraperitoneal
guinea pig
lowest published lethal dose: 100 mg/kg N/R NIHBAZ 181,1,1943
intraperitoneal
mouse
lethal dose (50 percent kill): 1,200 mg/kg N/R JJIND8 62,911,1979
intraperitoneal
rat
lowest published lethal dose: 18 mg/kg N/R XPHPAW 2173,23,1972
intratracheal
dog
lowest published lethal dose: 1,000 g/kg N/R XPHPAW 2173,23,1972
intratracheal
monkey
lowest published lethal dose: 1,000 g/kg N/R XPHPAW 2173,23,1972
intratracheal
rat
lowest published lethal dose: 10 mg/kg N/R XPHPAW 2173,23,1972
intravenous
dog
lowest published lethal dose: 600 g/kg N/R XPHPAW 2173,23,1972
intravenous
monkey
lowest published lethal dose: 600 g/kg N/R XPHPAW 2173,23,1972
intravenous
mouse
lethal dose (50 percent kill): 0.265 mg/kg N/R VCVN1* -,93,1988
intravenous
rat
lethal dose (50 percent kill): 7,200 g/kg N/R XPHPAW 2173,23,1972
oral
mouse
lethal dose (50 percent kill): 80 mg/kg N/R VCVN1* -,93,1988
oral
rat
lethal dose (50 percent kill): 82 mg/kg N/R VCVN1* -,93,1988
subcutaneous
mouse
lethal dose (50 percent kill): 1,500 g/kg N/R XPHPAW 2173,23,1972
subcutaneous
rat
lethal dose (50 percent kill): 1,500 g/kg N/R XPHPAW 2173,23,1972
subcutaneous
rabbit
lethal dose (50 percent kill): 1,500 g/kg N/R XPHPAW 2173,23,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
dog
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
dog
lowest published toxic concentration: 0.4 mg/m3/100 day- intermittent Blood: Macrocytosis HBTME* -,415,2007
inhalation
domestic animal
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
guinea pig
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1.1 mg/m3/6 hour/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988
inhalation
monkey
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
mouse
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
pig
lowest published toxic concentration: 50 mg(Be)/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
rat
lowest published toxic concentration: 10 mg/m3/6 hour/95 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
rat
lowest published toxic concentration: 2.59 mg/m3/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBTME* -,415,2007
inhalation
rat
lowest published toxic concentration: 0.43 mg/m3/100 day- intermittent Blood: Macrocytosis HBTME* -,415,2007
inhalation
rabbit
lowest published toxic concentration: 0.43 mg/m3/100 day- intermittent Blood: Macrocytosis HBTME* -,415,2007
oral
rat
lowest published toxic dose: 2,682 mg/kg/52 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
CHYCDW 22,335,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m3;short term exposure limit 0.01 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993
TOXICOLOGY REVIEW
CTOXAO 6,497,1973
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 533,99,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
HBTME* ,415,2007
TOXICOLOGY REVIEW
HBTME* ,177,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.002 mg(Be)/m3 (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg(Be)/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.006 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg(Be)/m3, continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg(Be)/m3, 2A carcinogen, sen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Be)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg(Be)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9972;
Number of Industries 3;
Total Number of Facilities 30;
Number of Occupations 4;
Total Number of Employees Exposed 120


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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