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Beryllium fluoride

RTECS #: DS2800000

CAS #: 7787-49-7


UPDATE: May 2009 MW: 47.01 MF: BeF2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Beryllium difluoride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 20 g/m3/1 hour/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GTPZAB 19(7),34,1975
inhalation
rat
toxic concentration (other than lowest) : 49 g/m3/26 week Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PEXTAR 2,203,1961


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lethal dose (50 percent kill): 21 mg/kg N/R XEURAQ UR-154,1951
intravenous
mouse
lethal dose (50 percent kill): 1,800 g/kg N/R XPHPAW 2173,23,1972
oral
mouse
lethal dose (50 percent kill): 18 mg/kg N/R HBTME* -,415,2007
oral
rat
lethal dose (50 percent kill): 98 mg/kg N/R XEURAQ UR-154,1951
subcutaneous
mouse
lethal dose (50 percent kill): 20 mg/kg N/R XPHPAW 2173,23,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 10 mg/m3/6 hour/30 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHBC 8,493,1953
inhalation
dog
lowest published toxic concentration: 1 mg/m3/6 hour/30 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 8,493,1953
inhalation
guinea pig
lowest published toxic concentration: 10 mg/m3/6 hour/30 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 8,493,1953
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1.1 mg/m3/6 hour/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988
inhalation
monkey
lowest published toxic concentration: 0.184 mg/m3/7 day- intermittent Cardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBTME* -,415,2007
inhalation
mouse
lowest published toxic concentration: 10 mg/m3/6 hour/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 8,493,1953
inhalation
rat
lowest published toxic concentration: 1 mg/m3/6 hour/30 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 8,493,1953
inhalation
rat
lowest published toxic concentration: 0.4 mg(Be)/m3/1 hour/16 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
rat
lowest published toxic concentration: 0.4 mg(Be)/m3/1 hour/78 week- intermittent Lung, Thorax, or Respiration: Bronchogenic carcinoma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation
rabbit
lowest published toxic concentration: 1 mg/m3/6 hour/30 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
AMIHBC 8,493,1953
inhalation
rabbit
lowest published toxic concentration: 2.2 mg/m3/23 week- intermittent Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m3;short term exposure limit 0.01 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993
TOXICOLOGY REVIEW
CTOXAO 6,497,1973
TOXICOLOGY REVIEW
AMIHBC 8,1,1953
TOXICOLOGY REVIEW
MUREAV 533,183,2003
TOXICOLOGY REVIEW
HBTME* ,415,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.002 mg(Be)/m3 (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg(Be)/m3, OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.006 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg(Be)/m3, continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY ceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg(Be)/m3, 2A carcinogen, sen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.002 mg(Be)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Be)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg(F)/m3,KZG- week 4 mg(F)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg(Be)/m3, 2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in production of BERYLLIUM and its alloys
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTME*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. (Rochester, NY)
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-

Used as an intermediate in production of BERYLLIUM and its alloys

RTECS Compound Description:
   Tumorigen

ALT CAS #: 12323-05-6
Click Here for Additional Information about RTECS

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